Results 111 to 120 of about 83,539 (316)

Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods

open access: yesPharmaceutics, 2019
The aims of this study were to investigate how the release of tadalafil is influenced by two grades of polyvinylpyrrolidone (Kollidon® 12 PF and Kollidon® VA 64) and various methods of preparing solid dispersions (solvent evaporation, spray ...
Tereza Školáková   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The evolution of dispersal

open access: yesJournal of Mathematical Biology, 2003
A non-local model for dispersal with continuous time and space is carefully justified and discussed. The necessary mathematical background is developed and we point out some interesting and challenging problems. While the basic model is not new, a 'spread' parameter (effectively the width of the dispersal kernel) has been introduced along with a ...
Hutson, V   +3 more
openaire   +5 more sources

Why organically functionalized nanoparticles increase the electrical conductivity of nematic liquid crystal dispersions

open access: yes, 2017
peer reviewedDoping liquid crystals with gold nanoparticles increases the conductivity by up to three orders of magnitude, an increase even stronger than expected for equimolar amounts of organic electrolytes. Despite recent high activity in the field of
LAGERWALL, Jan   +3 more
core   +1 more source

Síntesis y caracterización de adhesivos reposicionables de poliuretano dispersos en agua, obtenidos a partir de aceite de castor maleinizado Synthesis and characterization of pressure-sensitive adhesives of waterborne polyurethane from maleinizated castor oil

open access: yesPolímeros, 2010
El presente trabajo se centró en la producción de dispersiones acuosas de poliuretano empleando el método de emulsificación por inversión de fases. Para la síntesis fueron empleados dos polioles: uno comercial tipo poliéster y el otro es aceite de castor
Paula Mazo   +3 more
doaj  

Amorphous Solid Dispersions: Implication of Method of Preparation and Physicochemical Properties of API and Excipients

open access: yesPharmaceutics
The present study investigated the effect of different polymers and manufacturing methods (hot melt extrusion, HME, and spray drying, SD) on the solid state, stability and pharmaceutical performance of amorphous solid dispersions.
Varun Kushwah   +3 more
doaj   +1 more source

Synthesis of Water-Based Dispersions of Polymer/TiO2 Hybrid Nanospheres

open access: yesNanomaterials, 2015
We develop a strategy for preparing water-based dispersions of polymer/TiO2 nanospheres that can be used to form composite materials applicable in various fields. The formed hybrid nanospheres are monodisperse and possess a hierarchical structure.
Lu Jin, Hua Wu, Massimo Morbidelli
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Scanning Electronic Microscopy for analysis of the effects of surfactants on de-wrinkling and dispersion of graphene

open access: yes, 2015
Graphene was dispersed using a tip sonicator and the effect of surfactants were analysed. Sodium Dodecyl Sulphate (SDS) and Polyvinyl Alcohol (PVA) were compared to observe whether or not they had any effect on any de-wrinkling, and secondly whether they
Inam, Fawad   +5 more
core   +1 more source

Applying Supercritical Fluid Technology to Prepare Ibuprofen Solid Dispersions with Improved Oral Bioavailability

open access: yesPharmaceutics, 2019
In this study, supercritical fluid (SCF) technology was applied to prepare reliable solid dispersions of pharmaceutical compounds with limited bioavailability using ibuprofen (IBU) as a model compound.
Fei Han   +6 more
doaj   +1 more source

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