Results 91 to 100 of about 1,947 (193)

Crystal structure of 1′,1′′-dimethyl-4′-(4-cholorophenyl)dispiro[11H-indeno[1,2-b]quinoxaline-11,2′-pyrrolidine-3′,3′′-piperidin]-4′′-one

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C30H27ClN4O, the central pyrrolidine ring adopts an envelope conformation with the methylene C atom being the flap. The quinoxaline and indane rings are each essentially planar, with r.m.s. deviations of 0.027 (1) and 0.0417 (1) Å,
R.A. Nagalakshmi, J. Suresh, K. Malathi, R. Ranjith Kumar, P. L. Nilantha Lakshman   +4 more
doaj   +1 more source

Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials [PDF]

, 2014
Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria, but next-generation synthetic drug candidates are urgently required to improve availability and respond to the emergence of artemisinin-resistant parasites.
Bringela, A., Chadwick, J., Copple, I. M., Cristiano, Maria Lurdes Santos, Donegan, G., Firman, J., Herpers, B., Mercer, A. E., O'Neill, Paul M., Park, B. K., Van De Water, B., Ward, Stephen A., Wong, M. H.   +12 more
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Utilização de peróxidos com atividade antiparasitária como agentes anticancerígenos [PDF]

, 2014
Dissertação de mestrado, Ciências Farmacêuticas, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2014Cancro é um termo genérico que se utiliza para designar doenças em que as células se dividem sem controlo, podendo invadir outros tecidos do
Sena, Maria Inês Alves de
core  

Selective synthesis of spiro and dispiro compounds using Mn(III)-based oxidation of tetracarbonyl compounds [PDF]

, 2020
The Mn(III)-based oxidation of methylenebis(cyclohexanedione)s and methylenebis(piperidinedione)s as a tetracarbonyl compound was investigated under various conditions, selectively producing spiro dihydrofurans and dispiro cyclopropanes depending on the ...
Hiroshi, Nishino, Kazuki, Hisano, Keisuke, Shibuya, Satomi, Nishikawa, Suzuka, Yokote   +4 more
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Das Dispiro[5.1.5.1]tetradecan-Gerüst als Baustein für thermotrope Flüssigkristalle / Thermotropic Liquid Crystals Containing the Dispiro[5.1.5.1]tetradecane Unit

Zeitschrift für Naturforschung B, 1986
Abstract Several 3 .11-disubstituted dispiro[5.1.5.1]tetradecane-7,14-dions were prepared and the cis/trans-isomers were separated. The trans -stereoisomers were converted into the gem-dihalide ketones and mono- and dithioketones. The phase transfer temperatures were determined. Liquid crystal phases were observed.
W. Calaminus, F. Vögtle, R. Eidenschink
openaire   +1 more source

syn-Dispiro[1,3-dioxolane-2,17′-pentacyclo[12.2.1.16,9.02,13.05,10]octadecane-18′,2′′-[1,3]dioxolane]-7′,15′-diene

Acta Crystallographica Section E, 2010
The title compound, C22H28O4, is composed of a central octadecane ring and two spiro[bicyclo[2.2.1]hept[2]ene-7,2′-[1,3]dioxolane] units.
Rulla M. Kachlan, Macey C. Ruble, Jacob C. Timmerman, Markus Etzkorn, Daniel S. Jones   +4 more
doaj   +1 more source

1′,1′′-Dimethyl-4′-(4-methylphenyl)dispiro[11H-indeno[1,2-b]quinoxaline-11,2′-pyrrolidine-3′,3′′-piperidin]-4′′-one

Acta Crystallographica Section E, 2013
In the title compound, C31H30N4O, the central pyrrolidine ring adopts an envelope conformation with the methylene C atom being the flap. The quinoxaline and indane rings are each planar, having r.m.s.
R. A. Nagalakshmi, J. Suresh, K. Malathi, R. Ranjith Kumar, P. L. N. Lakshman   +4 more
doaj   +1 more source

rac-Methyl (1R,3′S)-1′,1′′-dimethyl-2,2′′-dioxo-2H-dispiro[acenaphthylene-1,2′-pyrrolidine-3′,3′′-indoline]-4′-carboxylate

Acta Crystallographica Section E, 2013
In the title compound, C26H22N2O4, the pyrrolidine ring adopts a twisted conformation and the other five-membered rings adopt envelope conformations with the spiro C atoms as the flap atoms.
G. Ganesh, Panneer Selvam Yuvaraj, Chinthalapuri Divakara, Boreddy S. R. Reddy, A. SubbiahPandi   +4 more
doaj   +1 more source

Synthesis and Antimalarial Activity of Sixteen Dispiro-1,2,4,5-tetraoxanes: Alkyl-Substituted 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes [PDF]

, 2000
Sixteen alkyl-substituted dispiro-1,2,4,5-tetraoxanes (7,8,15,16-tetraoxadispiro[5.2.5.2]hexadecanes) were synthesized to explore dispiro-1,2,4,5-tetraoxane SAR and to identify tetraoxanes with better oral antimalarial activity than prototype tetraoxane ...
Ager, Arba L., Jr., Dong, Yuxiang, Edwards, Geoffrey, Fu, Hong-Ning, Holme, Alexandra D., McLean, W. Graham, Vennerstrom, Jonathan L., Walter Reed Army Institute of Research, Walter Reed Army Institute of Research, Walter Reed Army Institute of Research, Walter Reed Army Institute of Research, Walter Reed Army Institute of Research, Walter Reed Army Institute of Research, Walters, sheri M., Wood, James K.   +14 more
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Studies of the thermal rearrangements of dispiro-1,2,4-Trioxanes [PDF]

, 2009
A series of α-alkoxy-3,6-dispiro-1,2,4-trioxanes have been synthesised by acid-catalysed perhydrolyses of α-alkoxy methylenecyclohexane oxides (provides ring A) to give selectively the corresponding 1-hydroperoxy-1-(hydroxymethyl)cyclohexanes followed
Taylor, Benjamin J.
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