Results 101 to 110 of about 1,947 (193)

New procedure for the preparation of highly sterically hindered alkenes using a hypervalent iodine reagent [PDF]

, 2005
New methodology is described to construct the olefinic bond in overcrowded alkenes using a hypervalent iodine reagent, and applied in the synthesis of molecular ...
Davey, Stephen G., Feringa, Bernard, Meetsma, Auke, Vicario, Javier, Wiel, Matthijs K.J. ter   +4 more
core   +2 more sources

Leveraging Aberrant Iron Metabolism as a Method for Selective Drug Delivery and Imaging In Vivo [PDF]

, 2019
Iron is a nutrient essential for cell growth and proliferation, however too high of a concentration can cause the formation of toxic reactive oxygen species. As a result, normal cells tightly regulate iron metabolism.
Muir, Ryan Keith
core  

Dispiro- 1,2,4,5-tetraoxanes: A New Class of Antimalarial Peroxides [PDF]

, 1992
Dispiro-l,2,4,5tetraoxanes2 -4 were synthesized as potential peroxide a n t h a l a* d drugs. They had curative activity against Plasmodium berghei in vivo at single doses of 320 and 640 mg/kg which confirms earlier unpublished data Moreover, artemisinin
Ager, Arba L., Jr., Fu, Hong-Ning, Vennerstrom, Jonathan L., Walter Reed Army Institute of Research, Walter Reed Army Institute of Research, Walter Reed Army Institute of Research, Walter Reed Army Institute of Research, Wood, James K.   +7 more
core   +1 more source

Azomethine Ylides-Versatile Synthons for Pyrrolidinyl-Heterocyclic Compounds. [PDF]

Molecules, 2023
Panda SS, Aziz MN, Stawinski J, Girgis AS.   +3 more
europepmc   +1 more source

Methyl-Substituted Dispiro-1,2,4,5-tetraoxanes:  Correlations of Structural Studies with Antimalarial Activity [PDF]

, 2000
Two tetramethyl-substituted dispiro-1,2,4,5-tetraoxanes (7,8,15,16-tetraoxadispiro[5.2.5.2]- hexadecanes) 3 and 4 were designed as metabolically stable analogues of the dimethylsubstituted dispiro-1,2,4,5-tetraoxane prototype WR 148999 (2).
Dong, Yuxiang, McCollough, Kevin J., Vennerstrom, Jonathan L., Walter Reed Army Institute of Research, Walter Reed Army Institute of Research, Walter Reed Army Institute of Research, Wood, James K.   +6 more
core   +1 more source

Synthesis and Antimalarial Activity of 11 Dispiro-1,2,4,5-tetraoxane Analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes Substituted at the 1 and 10 Positions with Unsaturated and Polar Functional Groups [PDF]

, 1999
Eleven novel dispiro-1,2,4,5-tetraoxanes 3 bearing unsaturated and polar functional groups were designed to enhance the oral antimalarial activity of the prototype tetraoxane 2 (WR 148999).
Chollet, Jacques, Dong, Yuxiang, F. Hoffmann-LaRoche Ltd., Kaminsky, Ronald, Vennerstrom, Jonathan L., Wood, James K.   +5 more
core   +1 more source

Synthesis and crystal structure (3R,4′S)-4′-(3,5-dibromophenyl)-1′-methyl-2H-dispiro [benzofuran-3,3′-pyrrolidine-2′,2″-indene]-1″,2,3″-trione, C26H17Br2NO4

Zeitschrift für Kristallographie - New Crystal Structures
C26H17Br2NO4, triclinic, P1¯ (no. 2), a = 8.3900(2) Å, b = 11.9445(2) Å, c = 12.4155(2) Å, α = 74.4620(10)°, β = 81.802(2)°, γ = 70.601(2)°, V = 1128.72(4) Å3, Z = 2, Rgt(F) = 0.0449, wRref(F2) = 0.1228, T = 249(1) K.
Chai Yi-Hui, Fan Zhi-Ling, Dong Zhang-Chao, Shi Yang, Liu Li-Juan, Pan Bo-Wen, Yang Fang-Fang   +6 more
doaj   +1 more source

Engaging Isatins and Amino Acids in Multicomponent One-Pot 1,3-Dipolar Cycloaddition Reactions-Easy Access to Structural Diversity. [PDF]

Molecules, 2023
Zhao H, Zhao Y.
europepmc   +1 more source

Dispiro-1,2,4-trioxane Analogues of a Prototype Dispiro-1,2,4-trioxolane: Mechanistic Comparators for Artemisinin in the Context of Reaction Pathways with Iron(II) [PDF]

, 2005
Single electron reduction of the 1,2,4-trioxane heterocycle of artemisinin (1) forms primary and secondary carbon-centered radicals. The complex structure of 1 does not lend itself to a satisfactory dissection of the electronic and steric effects that ...
Dong, Yuxiang, Sriraghavan, Kamaraj, Tang, Yuanqing, Vennerstrom, Jonathan L., Wang, Xiaofang, Wood, James K.   +5 more
core   +1 more source

Synthesis, Structure and Stereochemistry of Dispirocompounds Based on Imidazothiazolotriazine and Pyrrolidineoxindole. [PDF]

Int J Mol Sci, 2022
Izmest'ev AN, Karnoukhova VA, Larin AA, Kravchenko AN, Fershtat LL, Gazieva GA.   +5 more
europepmc   +1 more source