Results 121 to 130 of about 638,439 (343)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

What it means for women [PDF]

Forced Migration Review, 2008
Although climate change affects everyone, it is notgender neutral.
Women’s Environment and Development Organization
doaj  

Displacement Interferometry applied to Acoustics and to Gravitation [PDF]

, 1922
Carl Barus
openalex   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Trafficking: immigration or human rights concern? [PDF]

Forced Migration Review, 2006
Leading UK agencies have urged the UK government to do more to protect the victims of trafficking.
Beth Herzfeld, Sarah Green, Sarah Epstein, Christine Beddoe   +3 more
doaj  

Displacement of Spectral Lines [PDF]

, 1920
ROBERT W. LAWSON
openalex   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

In their own words [PDF]

Forced Migration Review, 2007
In Burundi, the Democratic Republic of Congo (DRC) and Sierra Leone, the end of armed fighting has not brought with it the longed-for peace. Today, an epidemic of gender-based violence continues to undermine efforts to bring stability.
doaj  

Totally Non-coisotropic Displacement and Its Applications to Hamiltonian Dynamics [PDF]

arXiv, 2007
In this paper we prove the Conley conjecture and the almost existence theorem in a neighborhood of a closed nowhere coisotropic submanifold under certain natural assumptions on the ambient symplectic manifold. Essential to the proofs is a displacement principle for such submanifolds. Namely, we show that a topologically displaceable nowhere coisotropic
arxiv