Results 131 to 140 of about 638,439 (343)

Time, the final frontier

open access: yesMolecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain   +3 more
wiley   +1 more source

Health challenges [PDF]

open access: yesForced Migration Review, 2008
There are no easy solutions to the emerging implications for health of climate change-related migration.
Manuel Carballo   +2 more
doaj  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Sexual and reproductive health rights of Colombian IDPs [PDF]

open access: yesForced Migration Review, 2004
Meeting the sexual and reproductive needs ofdisplaced Colombians must be part of a process ofrestoring their lost rights of citizenship.
Carlos Iván Pacheco Sánchez   +1 more
doaj  

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

Farmwork and family: How mixed-status families influence the mental health of foreign born farmworkers

open access: yesSSM - Mental Health
Immigrant agricultural workers, especially unauthorized workers, face a range of severe stressors, including isolation, chronic job insecurity, and marginalization, leading to higher rates of mental health issues compared to native-born populations. This
Helen Elizabeth Lindsay   +2 more
doaj  

Asia’s new boat people [PDF]

open access: yesForced Migration Review, 2008
Thousands of stateless Rohingyas are leaving Burma andBangladesh, dreaming of a better life in Malaysia.
Chris Lewa
doaj  

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

open access: yesFEBS Open Bio, EarlyView.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang   +11 more
wiley   +1 more source

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