Results 71 to 80 of about 2,396,820 (308)

A disruptive sequencer meets disruptive publishing [PDF]

F1000Research, 2015
Nanopore sequencing was recently made available to users in the form of the Oxford Nanopore MinION. Released to users through an early access programme, the MinION is made unique by its tiny form factor and ability to generate very long sequences from single DNA molecules.
Nick Loman, Sarah Goodwin, Hans J. Jansen, Matt Loose   +3 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Spectroscopic Signatures of the Tidal Disruption of Stars by Massive Black Holes

, 2011
During the tidal disruption of a star by a massive black hole (BH) of mass MBH
Balcells, Bernardi, Binney, Castor, Donley, Dotan, Drory, Eliot Quataert, Ferland, Gezari, Gezari, Hopkins, Häring, Katz, King, Kochanek, Komossa, Li, Linda E. Strubbe, Lodato, Lodato, Loeb, Magorrian, Murray, Noeske, Ohsuga, Ohsuga, Ohsuga, Phinney, Rees, Rossi, Scannapieco, Shen, Strubbe, Takeuchi, Verhamme, Wang, Yüksel   +37 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Travel Disruption: Three Case Studies [PDF]

This report draws together the findings of three studies of travel disruption and its impacts on travellers: the volcanic ash cloud which disrupted aviation in Europe in 2010, the loss of road bridges between November 2009 and April 2010 at Workington ...
Disruption Project, Guiver, Jo W
core  

The Tidal Disruption of Giant Stars and Their Contribution to the Flaring Supermassive Black Hole Population

, 2012
Sun-like stars are thought to be regularly disrupted by supermassive black holes (SMBHs) within galactic nuclei. Yet, as stars evolve off the main sequence their vulnerability to tidal disruption increases drastically as they develop a bifurcated ...
Alexander, Alexander, Antonini, Bartko, Baumgardt, Baumgardt, Binney, Bloecker, Chandrasekhar, Chen, Chen, Chen, De Colle, Diener, Enrico Ramirez-Ruiz, Ferrarese, Frank, Frank, Fryxell, Gebhardt, Gezari, Greene, Guillochon, Guillochon, Guillochon, Gültekin, Gürkan, Haas, Habing, Heckman, Hopman, Ivanov, James Guillochon, Kasen, Kelly, Kelly, Kobayashi, Kosovichev, Lauer, Luminet, Luminet, MacLeod, Madigan, Maeder, Magorrian, Maness, Merritt, Merritt, Merritt, Merritt, Milosavljevic, Montesinos Armijo, Morgan MacLeod, Passy, Paxton, Perets, Ramirez-Ruiz, Reimers, Richstone, Rogers, Rosswog, Rosswog, Schawinski, Shakura, Timmes, Tremaine, Turk, Ulmer, van Velzen, Wang, Wegg   +70 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Complex leadership as a way forward for transformational missional leadership in a denominational structure

HTS Teologiese Studies/Theological Studies, 2015
The research investigates the role of leadership in the transformation of denominational structures towards a missional ecclesiology, and focusses on the Highveld Synod of the Dutch Reformed Church. It describes the missional journey of the denomination,
C.J.P. (Nelus) Niemandt
doaj   +1 more source

Observational Constraints on the Catastrophic Disruption Rate of Small Main Belt Asteroids

, 2014
We have calculated 90% confidence limits on the steady-state rate of catastrophic disruptions of main belt asteroids in terms of the absolute magnitude at which one catastrophic disruption occurs per year (HCL) as a function of the post-disruption ...
Burgett, W. S., Chambers, K. C., Denneau, Larry, Draper, P. W., Fitzsimmons, Alan, Flewelling, H., Granvik, Mikael, Hsieh, Henry, Huber, M. E., Jedicke, Robert, Kaiser, N., Kleyna, Jan, Micheli, Marco, Morgan, J. S., Spahr, T., Tonry, J. L., Vereš, Peter, Wainscoat, Richard   +17 more
core   +1 more source

Linguistic Interventions and Transformative Communicative Disruption [PDF]

, 2020
What words we use, and what meanings they have, is important. We shouldn't use slurs; we should use 'rape' to include spousal rape (for centuries we didn’t); we should have a word which picks out the sexual harassment suffered by people in the workplace ...
Sterken, Rachel Katharine
core