Results 81 to 90 of about 1,458,434 (297)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A tale of two crises: COVID-19 and climate
Sustainability: Science, Practice, & Policy, 2020 In response to the COVID-19 pandemic, governments around the world are mobilizing unprecedented public resources to mitigate economic collapse. However, these new programs run the risk of paying insufficient attention to the multiple sustainability ...
Jochen Markard, Daniel Rosenbloom
doaj +1 more source
, 2019 Data were collected from Xenopus boumbaensis, Xenopus laevis South Africa and Xenopus victorianus ex vivo larynx preparations. Audio recordings were made in Amadeus and frequency values were extracted from recordings using custom script written in MatLab.
Hall, Ian +11 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The Impossible Temptation of Noise in Late Eighteenth-Century English Music
Etudes Epistémè, 2016 As Hogarth’s famous print, The Enraged Musician, makes clear, “sound” and “noise” are antithetical notions. Noise is defined negatively as a disruptive element. “It works as a deconstruction”, Paul Hegarty claims.
Pierre Dubois
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
CellsBackground: Preeclampsia (PE) is a critical complication of pregnancy that affects 3% to 5% of all pregnancies and has been linked to aberrant placentation, causing severe maternal and fetal illness and death.
Balu Usha Rani +4 more
doaj +1 more source
Rising marital disruption in Italy and its correlates [PDF]
Most of our knowledge on divorce pertains to the USA and northern Europe, while demographic studies from southern Europe are relatively scarce. Our study looks at this knowledge gap through an analysis of the correlates of marital instability in Italy ...
Daniele Vignoli, Irene Ferro
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source