Results 81 to 90 of about 2,396,820 (308)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Assessing the critical material constraints on low carbon infrastructure transitions
, 2013 We present an assessment method to analyze whether the disruption in supply of a group of materials endangers the transition to low-carbon infrastructure. We define criticality as the combination of the potential for supply disruption and the exposure of
Busch, J +4 more
core
National Culture\u27s Impact on Effectiveness of Supply Chain Disruption Management [PDF]
, 2016 The purpose of this research is to understand the national cultural antecedents that may help explain differences in supply chain disruptions mitigation abilities of companies from different countries.
Demirag, Ozgun C. +2 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Circumbinary discs from tidal disruption events
, 2017 Tidal disruption events, which occur when a star is shredded by the tidal field of a supermassive black hole, provide a means of fueling black hole accretion. Here we show, using a combination of three body orbit integrations and hydrodynamic simulations,
Armitage, Philip J., Coughlin, Eric R.
core +1 more source
Inter-population variability in the reproductive morphology of the shore crab (Carcinus maenas): Evidence of endocrine disruption in a marine crustacean? [PDF]
, 2005 Environmental contaminants that are capable of causing endocrine disrupting effects are currently a major cause for concern. These chemicals are known to influence the reproductive development of vertebrates by mimicking or antagonising the actions of ...
Brian, JV
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
A tale of two crises: COVID-19 and climate
Sustainability: Science, Practice, & Policy, 2020 In response to the COVID-19 pandemic, governments around the world are mobilizing unprecedented public resources to mitigate economic collapse. However, these new programs run the risk of paying insufficient attention to the multiple sustainability ...
Jochen Markard, Daniel Rosenbloom
doaj +1 more source