Results 91 to 100 of about 2,396,820 (308)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The Impossible Temptation of Noise in Late Eighteenth-Century English Music

Etudes Epistémè, 2016
As Hogarth’s famous print, The Enraged Musician, makes clear, “sound” and “noise” are antithetical notions. Noise is defined negatively as a disruptive element. “It works as a deconstruction”, Paul Hegarty claims.
Pierre Dubois
doaj   +1 more source

The formation efficiency of close-in planets via Lidov-Kozai migration: analytic calculations

, 2016
Lidov-Kozai oscillations of planets in stellar binaries, combined with tidal dissipation, can lead to the formation of hot Jupiters (HJs) or tidal disruption of planets.
Lai, Dong, Liu, Bin, Muñoz, Diego J.
core   +1 more source

Analytical and numerical studies of central galactic outflows powered by tidal disruption events -- a model for the Fermi bubbles?

, 2020
Capture and tidal disruption of stars by the supermassive black hole in the Galactic center (GC) should occur regularly. The energy released and dissipated by this processes will affect both the ambient environment of the GC and the Galactic halo.
Breitschwerdt, D., Cheng, H., Chernyshov, D. O., Dai, L., Dogiel, V. A., Ko, C. M.   +5 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

DISRUPTING BANKING

Business Strategy Review, 2014
Can online P2P lenders deliver disruptive innovation to the world of banking?
Jeffery, P, Arnold, D
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Hydrodynamical Simulations to Determine the Feeding Rate of Black Holes by the Tidal Disruption of Stars: The Importance of the Impact Parameter and Stellar Structure

, 2015
The disruption of stars by supermassive black holes has been linked to more than a dozen flares in the cores of galaxies out to redshift $z \sim 0.4$. Modeling these flares properly requires a prediction of the rate of mass return to the black hole after
Antonini, Beloborodov, Carter, Carter, Chandrasekhar, Chandrasekhar, Chandrasekhar, Colella, De Colle, Diener, Diener, Enrico Ramirez-Ruiz, Frank, Fryxell, Gezari, Gezari, Guillochon, Guillochon, Haas, Ivanov, James Guillochon, Kasen, Kesden, Kesden, Kobayashi, Komossa, Komossa, Kroupa, Lee, Luminet, MacLeod, Madigan, Maeder, Murray, Ramirez-Ruiz, Rosswog, Rosswog, Sari, Stone, Tout, Truelove, Ulmer, van Velzen, Wang   +43 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Disruptive influence

eLife, 2013
Cachexia, a condition that kills about one-fifth of cancer patients, may be linked to Rb—a protein that is already linked to various cancers—moving from the cell nucleus to the cytoplasm.
Giulio Cossu, Artal Moreno-Fortuny, Urmas Roostalu   +2 more
openaire   +3 more sources