Results 1 to 10 of about 33,597 (137)

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension. [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 1986
Basic fibroblast growth factor (FGF) has been found to increase neuronal survival and neurite extension in a highly purified population of fetal rat hippocampal neurons under well-defined serum-free cell culture conditions. In the presence of FGF, neuronal survival after 7 days in culture on a simple plastic substrate is increased 4-fold, to 54% of the
Naoto Ueno, Andrew Baird, Cowan W M
exaly   +3 more sources

Synovial tissue from sites of joint pain in knee osteoarthritis patients exhibits a differential phenotype with distinct fibroblast subsets

EBioMedicine, 2021
Background: Synovial inflammation is associated with pain severity in patients with knee osteoarthritis (OA). The aim here was to determine in a population with knee OA, whether synovial tissue from areas associated with pain exhibited different synovial
Dominika E Nanus, Amel Badoume, Susanne N Wijesinghe, Andrea M Halsey, Patrick Hurley, Zubair Ahmed, Rajesh Botchu, Edward T Davis, Mark A Lindsay, Simon W Jones   +9 more
doaj   +1 more source

Generation and characterization of multipotent stem cells from established dermal cultures. [PDF]

PLoS ONE, 2012
Human multipotent skin derived precursor cells (SKPs) are traditionally sourced from dissociated dermal tissues; therefore, donor availability may become limiting.
Rebecca P Hill, Karl Gledhill, Aaron Gardner, Claire A Higgins, Heather Crawford, Clifford Lawrence, Christopher J Hutchison, William A Owens, Bo Kara, S Elizabeth James, Colin A B Jahoda   +10 more
doaj   +1 more source

A BMP-FGF morphogen toggle switch drives the ultrasensitive expression of multiple genes in the developing forebrain. [PDF]

PLoS Computational Biology, 2014
Borders are important as they demarcate developing tissue into distinct functional units. A key challenge is the discovery of mechanisms that can convert morphogen gradients into tissue borders.
Shyam Srinivasan, Jia Sheng Hu, D Spencer Currle, Ernest S Fung, Wayne B Hayes, Arthur D Lander, Edwin S Monuki   +6 more
doaj   +1 more source

Establishment and characterization of a primary cell culture derived from external auditory canal squamous cell carcinoma

FEBS Open Bio, 2021
There are no human cancer cell lines of external auditory canal origin available for research use. This report describes the establishment of a culture condition for external auditory canal squamous cell carcinoma, derived from human tumor tissue ...
Yuki Sekino, Akira Imaizumi, Noritaka Komune, Mayumi Ono, Kuniaki Sato, Shogo Masuda, Akiko Fujimura, Kensuke Koike, Takahiro Hongo, Ryutaro Uchi, Hideya Onishi, Takashi Nakagawa   +11 more
doaj   +1 more source

Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy

Clinical & Translational Immunology, 2020
Objectives Targeted immunotherapies such as chimeric antigen receptor (CAR)‐T cells are emerging as attractive treatment options for glioblastoma, but rely on identification of a suitable tumor antigen. We validated a new target antigen for glioblastoma,
Lisa M Ebert, Wenbo Yu, Tessa Gargett, John Toubia, Paris M Kollis, Melinda N Tea, Brenton W Ebert, Cedric Bardy, Mark van den Hurk, Claudine S Bonder, Jim Manavis, Kathleen S Ensbey, Mariana Oksdath Mansilla, Kaitlin G Scheer, Sally L Perrin, Rebecca J Ormsby, Santosh Poonnoose, Barbara Koszyca, Stuart M Pitson, Bryan W Day, Guillermo A Gomez, Michael P Brown   +21 more
doaj   +1 more source

The early postnatal nonhuman primate neocortex contains self-renewing multipotent neural progenitor cells. [PDF]

PLoS ONE, 2012
The postnatal neocortex has traditionally been considered a non-neurogenic region, under non-pathological conditions. A few studies suggest, however, that a small subpopulation of neural cells born during postnatal life can differentiate into neurons ...
Jihane Homman-Ludiye, Tobias D Merson, James A Bourne   +2 more
doaj   +1 more source

Persistent cell-autonomous circadian oscillations in fibroblasts revealed by six-week single-cell imaging of PER2::LUC bioluminescence. [PDF]

PLoS ONE, 2012
Biological oscillators naturally exhibit stochastic fluctuations in period and amplitude due to the random nature of molecular reactions. Accurately measuring the precision of noisy oscillators and the heterogeneity in period and strength of rhythmicity ...
Tanya L Leise, Connie W Wang, Paula J Gitis, David K Welsh   +3 more
doaj   +1 more source

INFLUENCE OF CELL DISSOCIATION PROCEDURES ON THE TUMORIGENICITY OF SIMIAN VIRUS 40 TRANSFORMED FIBROBLASTS [PDF]

, 1975
Mouse fibroblasts transformed by Simian Virus 40 (SV40) were examined for tumor forming ability in syngeneic BALB/c mice following dissociation from tissue culture dishes by two procedures. A significantly greater in vivo proliferative capacity was observed for cells dissociated by the tryspin-EDTA procedure, with the injected cell dose for tumor ...
Tenforde, T. S., Risius, J., Beckmann, A., Tobias, C. A., Gurney, E.   +4 more
openaire   +4 more sources

Cardiovascular progenitor cells and tissue plasticity are reduced in a myocardium affected by Becker muscular dystrophy

Orphanet Journal of Rare Diseases, 2020
We describe the association of Becker muscular dystrophy (BMD) derived heart failure with the impairment of tissue homeostasis and remodeling capabilities of the affected heart tissue.
Martin Pesl, Sarka Jelinkova, Guido Caluori, Maria Holicka, Jan Krejci, Petr Nemec, Aneta Kohutova, Vita Zampachova, Petr Dvorak, Vladimir Rotrekl   +9 more
doaj   +1 more source