Results 21 to 30 of about 33,942 (277)

Wnt Inhibition Facilitates RNA-Mediated Reprogramming of Human Somatic Cells to Naive Pluripotency

Stem Cell Reports, 2019
Summary: In contrast to conventional human pluripotent stem cells (hPSCs) that are related to post-implantation embryo stages, naive hPSCs exhibit features of pre-implantation epiblast.
Nicholas Bredenkamp, Jian Yang, James Clarke, Giuliano Giuseppe Stirparo, Ferdinand von Meyenn, Sabine Dietmann, Duncan Baker, Rosalind Drummond, Yongming Ren, Dongwei Li, Chuman Wu, Maria Rostovskaya, Sarah Eminli-Meissner, Austin Smith, Ge Guo   +14 more
doaj   +1 more source

Dissociating effect of salivary gland extract from Ixodes ricinus on human fibroblasts: Potential impact on Borrelia transmission [PDF]

Ticks and Tick-borne Diseases, 2019
Understanding the mechanism of pathogen transmission is essential for the development of strategies to reduce arthropod-borne diseases. The pharmaco- and immunomodulatory properties of insect and acarine saliva play an essential role in the efficiency of pathogen transmission.
Boeuf, Amandine, Schnell, Gilles, Bernard, Quentin, Kern, Aurelie, Westermann, Benoit, Ehret-Sabatier, Laurence, Grillon, Antoine, Schramm, Frédéric, Jaulhac, Benoît, Boulanger, Nathalie   +9 more
openaire   +3 more sources

Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential [PDF]

Acta Neuropathologica Communications, 2019
AbstractFibroblast growth factor (FGF) signaling contributes to failure of remyelination in multiple sclerosis, but targeting this therapeutically is complicated by its functional pleiotropy. We now identify FGF2 as a factor up-regulated by astrocytes in active inflammatory lesions that disrupts myelination via FGF receptor 2 (FGFR2) mediated ...
Thümmler, Katja, Rom, Eran, Zeis, Thomas, Lindner, Maren, Brunner, Sarah, Cole, John, Arseni, Diana, Mücklisch, Steve, Edgar, Julia, Schaeren-Wiemers, Nicole, Yayon, Avner, Linington, Christopher   +11 more
openaire   +5 more sources

Size-Optimized Microspace Culture Facilitates Differentiation of Mouse Induced Pluripotent Stem Cells into Osteoid-Rich Bone Constructs

Stem Cells International, 2020
Microspace culture is promising for self-organization of induced pluripotent stem cells (iPSCs). However, the optimal size of microspaces for osteogenic differentiation is unclear.
Phoonsuk Limraksasin, Hiroko Okawa, Maolin Zhang, Takeru Kondo, Thanaphum Osathanon, Prasit Pavasant, Hiroshi Egusa   +6 more
doaj   +1 more source

Role of proton dissociation in the transport of cystine and glutamate in human diploid fibroblasts in culture.

Journal of Biological Chemistry, 1981
The effect of extracellular pH on the transport interaction of cystine and glutamate in cultured human diploid cells was examined over the pH range of 5.8-8.0. The initial rates of uptake of cystine increased with an increase in pH and glutamate potently inhibited the cystine uptake independently of pH.
S, Bannai, E, Kitamura
openaire   +2 more sources

Peripheral Nerve Regeneration through Hydrogel-Enriched Chitosan Conduits Containing Engineered Schwann Cells for Drug Delivery

Cell Transplantation, 2016
Critical length nerve defects in the rat sciatic nerve model were reconstructed with chitosan nerve guides filled with Schwann cells (SCs) containing hydrogel.
Cora Meyer, Sandra Wrobel, Stefania Raimondo, Shimon Rochkind, Claudia Heimann, Abraham Shahar, Ofra Ziv-Polat, Stefano Geuna, Claudia Grothe, Kirsten Haastert-Talini   +9 more
doaj   +1 more source

Induced in Vitro Differentiation of β-Tubulin III Expressed Cells from Human Amniotic Epithelial Cells [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2009
Background and Objectives: The differentiation of neural cells from embryonic stem cells is influenced by several factors. Amniotic epithelial cells (AECs) share many of the same characteristics as embryonic stem cells, and therefore, those factors may ...
H. Niknejad, H. Peirovi, B. Jamber Nooshin, A. Ahmadiani, J. Ghanavi, M. Jorjani   +5 more
doaj   +2 more sources

Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1

Stem Cell Research & Therapy, 2018
Background Pancreatic progenitors (PPs) co-expressing the two transcription factors (TFs) PDX1 and NKX6.1 are recognized as the indispensable precursors of functional pancreatic β cells.
Bushra Memon, Manale Karam, Sara Al-Khawaga, Essam M. Abdelalim   +3 more
doaj   +1 more source

Malignant cell-specific CXCL14 promotes tumor lymphocyte infiltration in oral cavity squamous cell carcinoma

Journal for ImmunoTherapy of Cancer, 2020
Objectives To explore lymphocyte infiltration as a potential mechanism behind CXCL14-mediated tumor growth suppression in oral cavity squamous cell carcinoma (OSCC).Methods We analyzed single cell RNA-sequencing (scRNA-seq) data from OSCC to identify ...
John B Sunwoo, JuneHo Shin, Sidharth V Puram, Anuraag Parikh, William Faquin, Derrick T Lin, Itay Tirosh   +6 more
doaj   +1 more source

Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2

, 2006
FGF-2, a potent multifunctional and neurotrophic growth factor, is widely expressed in the brain and upregulated in cerebral ischemia. Previous studies have shown that intraventricularly or systemically administered FGF-2 reduces the size of cerebral ...
Kiprianova, Irina, Dono, Rosanna, Schindowski, Katharina, Krause, Sonja, Bohlen und Halbach, Oliver von, Schwaninger, Markus, Unsicker, Klaus   +6 more
core   +1 more source