Results 121 to 130 of about 889,606 (319)

Binary specification of nerve cord and notochord cell fates in ascidian embryos [PDF]

, 2001
In the ascidian embryo, the nerve cord and notochord of the tail of tadpole larvae originate from the precursor blastomeres for both tissues in the 32-cell-stage embryo. Each fate is separated into two daughter blastomeres at the next cleavage.
Makabe, Kazuhiro W., Minokawa, Takuya, Nishida, Hiroki, Yagi, Kasumi   +3 more
core  

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Insight into resistance mechanisms of AZD4547 and E3810 to FGFR1 gatekeeper mutation via theoretical study

Drug Design, Development and Therapy, 2017
Donglou Liang,1,* Qiaowan Chen,2,* Yujin Guo,1 Ting Zhang,3 Wentao Guo4 1Pharmacy Department, Jining First People’s Hospital, 2Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 3Department of ...
Liang D, Chen Q, Guo Y, Zhang T, Guo W
doaj  

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells [PDF]

, 2002
In the vertebrate peripheral nervous system, the proneural genes neurogenin 1 and neurogenin 2 (Ngn1 and Ngn2), and Mash1 are required for sensory and autonomic neurogenesis, respectively.
Anderson, David J., Dormand, Emma, Greenwood, Amy, Lo, Liching   +3 more
core  

MOESM6 of Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential

, 2019
Additional file 6. Online Resource 6: qPCR validation for Wnt pathway genes.
Thümmler, Katja, Rom, Eran, Zeis, Thomas, Lindner, Maren, Brunner, Sarah, Cole, John, Arseni, Diana, Mücklisch, Steve, Edgar, Julia, Schaeren-Wiemers, Nicole, Yayon, Avner, Linington, Christopher   +11 more
openaire   +1 more source

Expandable Nanocomposite Shape‐Memory Hemostat for the Treatment of Noncompressible Hemorrhage

Advanced Science, EarlyView.
A nanocomposite‐coated shape memory foam rapidly expands, accelerates clotting, and reduces blood loss in vivo. Its fast volumetric expansion and strong procoagulant activity make it a promising hemostat for treating deep, noncompressible hemorrhage.
Saptarshi Biswas, Sarah E. Miller, Shounak Roy, Jeevika Thazhaiselvam, Samantha Foster, Manivannan Sivaperuman Kalairaj, Sasha M. George, Yava Jones‐Hall, Staci J. Horn, Fred J. Clubb, Taylor H. Ware, Duncan J. Maitland, Akhilesh K. Gaharwar   +12 more
wiley   +1 more source

Characterisation of Embryonic Dermal Precursor Cells [PDF]

, 2018
Skin is an attractive organ for the acquisition of stem cells due to its accessibility, size and potential for autologous transplants. Research into skin development has implications for the isolation of stem cell populations, for example skin-derived ...
BLINCKO, SARAH
core  

MOESM3 of Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential

, 2019
Additional file 3. Online Resource 3: Differential regulation of myelin by FGF2 and F2 V2.
Thümmler, Katja, Rom, Eran, Zeis, Thomas, Lindner, Maren, Brunner, Sarah, Cole, John, Arseni, Diana, Mücklisch, Steve, Edgar, Julia, Schaeren-Wiemers, Nicole, Yayon, Avner, Linington, Christopher   +11 more
openaire   +1 more source