Results 11 to 20 of about 889,606 (319)

Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy

Clinical & Translational Immunology, 2020
Objectives Targeted immunotherapies such as chimeric antigen receptor (CAR)‐T cells are emerging as attractive treatment options for glioblastoma, but rely on identification of a suitable tumor antigen. We validated a new target antigen for glioblastoma,
Lisa M Ebert, Wenbo Yu, Tessa Gargett, John Toubia, Paris M Kollis, Melinda N Tea, Brenton W Ebert, Cedric Bardy, Mark van den Hurk, Claudine S Bonder, Jim Manavis, Kathleen S Ensbey, Mariana Oksdath Mansilla, Kaitlin G Scheer, Sally L Perrin, Rebecca J Ormsby, Santosh Poonnoose, Barbara Koszyca, Stuart M Pitson, Bryan W Day, Guillermo A Gomez, Michael P Brown   +21 more
doaj   +1 more source

The early postnatal nonhuman primate neocortex contains self-renewing multipotent neural progenitor cells. [PDF]

PLoS ONE, 2012
The postnatal neocortex has traditionally been considered a non-neurogenic region, under non-pathological conditions. A few studies suggest, however, that a small subpopulation of neural cells born during postnatal life can differentiate into neurons ...
Jihane Homman-Ludiye, Tobias D Merson, James A Bourne   +2 more
doaj   +1 more source

Dissociation of inositol trisphosphate from diacylglycerol production in Rous sarcoma virus-transformed fibroblasts. [PDF]

The Journal of cell biology, 1989
The metabolism of phosphatidylinositol (PI) and related intermediates was studied in uninfected and Rous sarcoma virus-(RSV) infected chicken embryo fibroblasts (CEFs). Cells infected with wild-type RSV exhibited twofold increases in steady-state concentrations of inositol trisphosphate (IP3) and inositol bisphosphate (IP2) as compared to uninfected ...
T J, Martins, Y, Sugimoto, R L, Erikson
openaire   +2 more sources

Persistent cell-autonomous circadian oscillations in fibroblasts revealed by six-week single-cell imaging of PER2::LUC bioluminescence. [PDF]

PLoS ONE, 2012
Biological oscillators naturally exhibit stochastic fluctuations in period and amplitude due to the random nature of molecular reactions. Accurately measuring the precision of noisy oscillators and the heterogeneity in period and strength of rhythmicity ...
Tanya L Leise, Connie W Wang, Paula J Gitis, David K Welsh   +3 more
doaj   +1 more source

Cardiovascular progenitor cells and tissue plasticity are reduced in a myocardium affected by Becker muscular dystrophy

Orphanet Journal of Rare Diseases, 2020
We describe the association of Becker muscular dystrophy (BMD) derived heart failure with the impairment of tissue homeostasis and remodeling capabilities of the affected heart tissue.
Martin Pesl, Sarka Jelinkova, Guido Caluori, Maria Holicka, Jan Krejci, Petr Nemec, Aneta Kohutova, Vita Zampachova, Petr Dvorak, Vladimir Rotrekl   +9 more
doaj   +1 more source

KULTUR PRIMER FIBROBLAS: PENELITIAN PENDAHULUAN

Majalah Kedokteran Andalas, 2015
AbstrakKultur sel fibroblas banyak digunakan untuk penelitian proses penyembuhan luka dan penuaankulit. Metode ini digunakan untuk melihat perkembangan sel, proliferasi kinetik seluler, sertabiosintesis komponen matriks ekstraseluler.
Yuli Kurniawati, Sudigdo Adi, Achadiyani Achadiyani, Oki Suwarsa, Dimas Erlangga, Tenny Putri   +5 more
doaj   +1 more source

Scatter factor : molecular characteristics and effect on the invasiveness of epithelial cells [PDF]

, 1990
The generation of invasiveness in transformed cells represents an essential step of tumor progression. We have previously shown that MDCK epithelial cells, which are deprived of intracellular adhesion by the addition of anti-Arc-1/uvomorulin antibodies ...
Behrens, Jürgen, Birchmeier, Walter, Vandekerckhove, Joël, Weidner, K Michael   +3 more
core   +2 more sources

Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential [PDF]

Acta Neuropathologica Communications, 2019
AbstractFibroblast growth factor (FGF) signaling contributes to failure of remyelination in multiple sclerosis, but targeting this therapeutically is complicated by its functional pleiotropy. We now identify FGF2 as a factor up-regulated by astrocytes in active inflammatory lesions that disrupts myelination via FGF receptor 2 (FGFR2) mediated ...
Thümmler, Katja, Rom, Eran, Zeis, Thomas, Lindner, Maren, Brunner, Sarah, Cole, John, Arseni, Diana, Mücklisch, Steve, Edgar, Julia, Schaeren-Wiemers, Nicole, Yayon, Avner, Linington, Christopher   +11 more
openaire   +4 more sources

Activation of aryl hydrocarbon receptor dissociates fatty liver from insulin resistance by inducing fibroblast growth factor 21 [PDF]

Hepatology, 2015
The aryl hydrocarbon receptor (AHR), also known as the dioxin receptor, was originally characterized as a xenobiotic receptor that senses xenotoxicants. We investigated the endobiotic and hepatic role of AHR in fatty liver and energy metabolism and identified the endocrine factor that mediates the metabolic function of AHR. Wild‐type and liver‐specific
Peipei, Lu, Jiong, Yan, Ke, Liu, Wojciech G, Garbacz, Pengcheng, Wang, Meishu, Xu, Xiaochao, Ma, Wen, Xie   +7 more
openaire   +3 more sources

Retention of progenitor cell phenotype in otospheres from guinea pig and mouse cochlea

Journal of Translational Medicine, 2010
Background Culturing otospheres from dissociated organ of Corti is an appropriate starting point aiming at the development of cell therapy for hair cell loss.
Haddad Luciana A, Mingroni-Netto Regina C, Lezirovitz Karina, Batissoco Ana, Barboza-Junior Luiz, Oiticica Jeanne, Bento Ricardo F   +6 more
doaj   +1 more source