Results 111 to 120 of about 1,227,945 (330)

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Separation of ions with the same charge to mass ratio from a collision experiment

open access: yesJournal of the Serbian Chemical Society, 2000
Some atomic collision experiments lead to ions having identical q/m ratio, as well as average velocity, so that standard electric and magnetic analyzers are not able to identify them separately.
PIERRE DEFRANCE, DRAGOLJUB S. BELIC
doaj  

Ventriculo-ventricular dissociation∗

open access: yesThe American Journal of Cardiology, 1960
Abstract In open chest experiments in forty-seven dogs, the electrical activity of the two ventricles was studied by means of simultaneously recorded epicardiac leads. In fourteen dogs, four types of ventriculo-ventricular dissociation were observed, namely, fibrillation and flutter; fibrillation and idio-ventricular rhythm; standstill and ...
Malamos, B., Moulopoulos, S.
openaire   +3 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Theory of Electric Field-Induced Photoluminescence Quenching in Disordered Molecular Solids

open access: yes, 1998
The dynamics of excitons in disordered molecular solids is studied theoretically, taking into account migration between different sites, recombination, and dissociation into free charge carriers in the presence of an electric field. The theory is applied
A. J. Epstein   +18 more
core   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

open access: yesFEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Trauma-related altered states of consciousness in post-traumatic stress disorder patients with or without comorbid dissociative disorders

open access: yesEuropean Journal of Psychotraumatology, 2018
Background: The four-dimensional (‘4-D’) model has been proposed as a theoretical framework to understand and delineate trauma-related dissociative experiences, categorizing symptoms into trauma-related altered states of consciousness (TRASC) and normal ...
Harald Bækkelund   +4 more
doaj   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

Dissociation and recovery in psychosis – an overview of the literature

open access: yesFrontiers in Psychiatry
BackgroundThe relationship between dissociation and recovery from psychosis is a new topic, which could attract the interest of the researchers in the field of dissociation due to its relevance to their daily clinical practice.
Claudia Calciu   +8 more
doaj   +1 more source

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