Results 101 to 110 of about 1,352,916 (332)

Acid solvation versus dissociation at “stardust conditions”: Reaction sequence matters

open access: yesScience Advances, 2019
Chemistry, such as dissociation of acids, can even be triggered at ultracold “stardust conditions” in the absence of radiation. Chemical reactions at ultralow temperatures are of fundamental importance to primordial molecular evolution as it occurs on ...
D. Mani   +10 more
semanticscholar   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

open access: yesFEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu   +6 more
wiley   +1 more source

Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β

open access: yesAdvanced Biology, EarlyView.
This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer   +8 more
wiley   +1 more source

Growing Prospects of Dynamic Covalent Chemistry in Delivery Applications.

open access: yesAccounts of Chemical Research, 2019
Delivery remains a major obstacle restricting the potential action of small molecular drugs as well as novel biologics which cannot readily enter cells without the help of a vector.
S. Ulrich
semanticscholar   +1 more source

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

open access: yesAdvanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran   +5 more
wiley   +1 more source

Mechanistic study of moisture corrosion of FeCr alloys in molten salts by ab-initio molecular dynamics simulations

open access: yesCommunications Materials
Molten salts are promising for various energy applications including fuel and solar cells and nuclear energy. These applications face a common challenge: corrosion of structural materials by impurities such as H2O.
Anton Schneider   +2 more
doaj   +1 more source

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