Results 101 to 110 of about 1,577,920 (354)
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Nature Communications, 2017 Increasing the operating temperatures of single-molecule magnets—molecules that can retain magnetic polarization in the absence of an applied field—has potential implications toward information storage and computing, and may also inform the development ...
Selvan Demir +4 more
semanticscholar +1 more source
Molecules, 2019 In the study reported herein, glovebox-protected X-ray photoelectron spectroscopy (XPS) and in situ Hall charge carrier measurements provide new insights into the surface physical chemistry of gaseous H2, CO2, and H2+CO2 combined with nanostructured In2O(
Joel Y. Y. Loh, Nazir P. Kherani
doaj +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Journal of Lipid Research, 2016 Electron impact excitation of ions from organics (EIEIO), also referred to as electron-induced dissociation, was applied to singly charged SM molecular species in the gas phase.
Takashi Baba +3 more
doaj
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
The Role of Electron Transfer Dissociation in Modern Proteomics
Analytical Chemistry, 2017 In the nearly fifteen years since electron transfer dissociation (ETD) was introduced,1 bioanalytical mass spectrometry (MS) and MS-driven proteomics have continued to develop as the premier tools for characterizing proteome composition, structure, and ...
N. Riley, J. Coon
semanticscholar +1 more source
Química Nova, 2014 An experiment was proposed applying the Chemometric approach of Multivariate Analysis for inclusion in undergraduate Chemistry courses to promote and expand the use of this analytical-statistical tool. The experiment entails the determination of the acid
Paulo Cesar de Souza Pereira +9 more
doaj +1 more source
Free radical OH, a molecule of astrophysical and aeronomic interest [PDF]
The chemistry and physics of the gaseous OH free radical as it applies to interstellar space, planetary atmospheres, and the sun is presented. Topics considered are: (1) rotational-vibrational transitions; (2) dissociation and ionization processes; (3 ...
Mohan, H., SHARDANAND
core +1 more source
Real-Space In Situ Bond Energies: Toward A Consistent Energetic Definition of Bond Strength [PDF]
, 2018 CTQ2015-65790-P; GRUPIN14-049, FICYT, Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la ...
Costales Castro, María Aurora +3 more
core +2 more sources