Results 41 to 50 of about 936,316 (178)

Enhancing Solubility and Dissolution Rate of Antifungal Drug Ketoconazole through Crystal Engineering

Pharmaceuticals, 2023
To improve the solubility and dissolution rate of the BCS class II drug ketoconazole, five novel solid forms in 1:1 stoichiometry were obtained upon liquid-assisted grinding, slurry, and slow evaporation methods in the presence of coformers, namely ...
Hongmei Yu, Li Zhang, Meiju Liu, Dezhi Yang, Guorong He, Baoxi Zhang, Ningbo Gong, Yang Lu, Guanhua Du   +8 more
doaj   +1 more source

Surface analysis of cannabigerol cocrystals: linking crystal structure to enhanced properties

IUCrJ
Cannabigerol is a bioactive compound derived from Cannabis sativa. It displays many promising pharmaceutical and nutraceutical properties. Its use and research are complicated by its thermally unstable solid form with low solubility and needle habit ...
Eliška Zmeškalová, František Stara, Tereza Havlůjová, Miroslav Šoóš   +3 more
doaj   +1 more source

Supersaturation and Precipitation Applicated in Drug Delivery Systems: Development Strategies and Evaluation Approaches

Molecules, 2023
Supersaturation is a promising strategy to improve gastrointestinal absorption of poorly water-soluble drugs. Supersaturation is a metastable state and therefore dissolved drugs often quickly precipitate again.
Yanxiong Gan, Jan P. A. Baak, Taijun Chen, Hua Ye, Wan Liao, Huixia Lv, Chuanbiao Wen, Shichao Zheng   +7 more
doaj   +1 more source

An analytical method for evaluating the transient swelling layer during polymer film development using quartz crystal microbalance

Applied Physics Express
During the lithography development process, the resist films absorb developer molecules and transiently swell before dissolving. This swelling layer is crucial for resist pattern formation.
Takahiro Kozawa, Kyoko Watanabe, Yuko Tsutsui Ito, Mikiko Kozawa, Yuqing Jin, Kayoko Cho, Takashi Hasebe, Kazuo Sakamoto, Makoto Muramatsu   +8 more
doaj   +1 more source

Orodispersible Polymer Films with the Poorly Water-Soluble Drug, Olanzapine: Hot-Melt Pneumatic Extrusion for Single-Process 3D Printing

Pharmaceutics, 2020
Amorphous solid dispersions (ASDs) improve the oral delivery of poorly water-soluble drugs. ASDs of olanzapine (OLZ), which have a high melting point and low solubility, are performed using a complicated process.
Hui-Won Cho, Seung-Hoon Baek, Beom-Jin Lee, Hyo-Eon Jin   +3 more
doaj   +1 more source

Dissolution in a field

, 2001
We study the dissolution of a solid by continuous injection of reactive ``acid'' particles at a single point, with the reactive particles undergoing biased diffusion in the dissolved region.
A. Gabrielli, E. Ben-Naim, G. Daccord, H. H. Uhlig, H. Larralde, H.F. Meng, H.S. Carslaw, I.S. Gradstein, J. Crank, J. Galambos, K.S. Kim, L.M. Cummings, M. Sahimi, S. Redner, S. Redner, S. Redner, W. Hwang, W. Hwang   +17 more
core   +1 more source

Self unbound: ego dissolution in psychedelic experience [PDF]

, 2017
Users of psychedelic drugs often report that their sense of being a self or ‘I’ distinct from the rest of the world has diminished or altogether dissolved.
Gerrans, Philip, Letheby, Chris
core   +2 more sources

Design of Experiment Approach for Enhancing the Dissolution Profile and Robustness of Loratadine Tablet Using D-α-Tocopheryl Polyethylene Glycol 1000 Succinate

Pharmaceutics
Background: Formulating poorly water-soluble drugs poses significant challenges due to their limited solubility and bioavailability. Loratadine (LTD), classified as a BCS II molecule, exhibits notably low solubility, leading to reduced bioavailability ...
Alhasan A. Jabbar, Israa Al-Ani, Ramadan I. Al-Shdefat, Nadia Ghazal, Anwar Jaffal, Mohamed H. Fayed   +5 more
doaj   +1 more source

Predicting the dissolution kinetics of silicate glasses using machine learning

, 2017
Predicting the dissolution rates of silicate glasses in aqueous conditions is a complex task as the underlying mechanism(s) remain poorly understood and the dissolution kinetics can depend on a large number of intrinsic and extrinsic factors.
Bauchy, Mathieu, Burton, Henry, Krishnan, N. M. Anoop, Mangalathu, Sujith, Smedskjaer, Morten M., Tandia, Adama   +5 more
core   +1 more source

Bubble dissolution in horizontal turbulent bubbly flow in domestic central heating system [PDF]

, 2013
In a domestic central heating system, the phenomenon of microbubble nucleation and detachment on the surface of a boiler heat exchanger finds its origins in the high surface temperature of the wall and consequential localised super saturation ...
Brunel University, Fsadni, A.M., Ge, Y.T., University of London, Wang, H.S.   +4 more
core   +1 more source