Results 41 to 50 of about 1,178,957 (338)
Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment
FEBS Letters, EarlyView.The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke +2 more
wiley +1 more source
Chemical Science, 2018 This perspective summarizes mechanistic studies on cellulose dissolution in ionic liquids, highlighting the synergistic mechanism, physicochemical aspects and future research trends.
Yao Li +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Automation of Dissolution Tests [PDF]
Dissolution Technologies, 2000 Dissolution testing of drug formulations was introduced in the 1960s and accepted by health regulatory authorities in the 1970s. Since then, the importance of dissolution has grown rapidly as have the number of tests and demands in quality‐control laboratories.
openaire +3 more sources
Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CE [PDF]
, 2014 Capillary electrophoresis (CE) was used to follow Diclofenac tablet dissolution, in very short times and allowing dissolution testing without volume replacement. By using Student´s t test and F-test, this CE method was compared with HPLC.
Delfino, Mario Raul +3 more
core +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Influence of presence of ammonium in the hydrothermal illitization of smectite [PDF]
, 2017 During diagenesis, several reactions induce changes both in phyllosilicates and organic matter, which in basins associated to the production of hydrocarbons leads to ammonium fixation in illite and micas [1] and to dissolution induced by organic acids [
Bentabol-Manzanares, Maria Jose
core
Predicting the dissolution kinetics of silicate glasses using machine learning
, 2017 Predicting the dissolution rates of silicate glasses in aqueous conditions is a complex task as the underlying mechanism(s) remain poorly understood and the dissolution kinetics can depend on a large number of intrinsic and extrinsic factors.
Bauchy, Mathieu +5 more
core +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source