Results 61 to 70 of about 525,078 (332)

Orodispersible Polymer Films with the Poorly Water-Soluble Drug, Olanzapine: Hot-Melt Pneumatic Extrusion for Single-Process 3D Printing

Pharmaceutics, 2020
Amorphous solid dispersions (ASDs) improve the oral delivery of poorly water-soluble drugs. ASDs of olanzapine (OLZ), which have a high melting point and low solubility, are performed using a complicated process.
Hui-Won Cho, Seung-Hoon Baek, Beom-Jin Lee, Hyo-Eon Jin   +3 more
doaj   +1 more source

Chronopotentiometric Analysis of the Anode Dissolution Process in Dimethyl Sulfone–Aluminum Chloride Electrolytic Solution [PDF]

, 2023
Junichi Matsuda, A. Okamoto, Haruo Akahoshi, Sayoko Shironita, Minoru Umeda   +4 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Design of Experiment Approach for Enhancing the Dissolution Profile and Robustness of Loratadine Tablet Using D-α-Tocopheryl Polyethylene Glycol 1000 Succinate

Pharmaceutics
Background: Formulating poorly water-soluble drugs poses significant challenges due to their limited solubility and bioavailability. Loratadine (LTD), classified as a BCS II molecule, exhibits notably low solubility, leading to reduced bioavailability ...
Alhasan A. Jabbar, Israa Al-Ani, Ramadan I. Al-Shdefat, Nadia Ghazal, Anwar Jaffal, Mohamed H. Fayed   +5 more
doaj   +1 more source

The bidirectional regulation mechanism of NMMO concentration change on cellulose dissolution and regeneration [PDF]

, 2023
Zikang Deng, Guohui Zhou, Timing Fang, Kuanjun Fang, Xiaomin Liu   +4 more
openalex   +1 more source

A Dissolution/Precipitation Equilibrium on the Surface of Iridium-Based Perovskites Controls Their Activity as Oxygen Evolution Reaction Catalysts in Acidic Media.

Angewandte Chemie, 2019
Recently, IrV -based perovskite-like materials were proposed as oxygen evolution reaction (OER) catalysts in acidic media with promising performance. However, iridium dissolution and surface reconstruction were observed, questioning the real active sites
Rong-hua Zhang, Nicolas Dubouis, Manel Ben Osman, Wei Yin, M. Sougrati, D. A. D. Corte, D. Giaume, A. Grimaud   +7 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Union of Brest and its Dissolution on the Territories of the Congress Kingdom of Poland, Belarusian and Lithuanian Lands

Journal on European History of Law, 2011
The conditions of the union of Brest were set on a meeting in Torczyn, on 2 December 1594. Once the union was announced in Rome on 12 June 1595, a synod was convoked to Brest.
Przemysław Dąbrowski
doaj  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Binary Mixtures of Some Active Pharmaceutical Ingredients with Fatty Alcohols—The Criteria of Successful Eutectic Formation and Dissolution Improvement

Pharmaceutics, 2020
Pharmaceutical eutectics are solid mixtures, where the crystals of active pharmaceutical ingredients (APIs) are finely divided in the phase-separated microstructures.
Songhee Jin, Jisun Jang, Soyeon Lee, Il Won Kim   +3 more
doaj   +1 more source