Results 81 to 90 of about 1,185,001 (388)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Understanding the role of ions and water molecules in the NaCl dissolution process [PDF]

, 2013
The dissolution of NaCl in water is one of the most common everyday processes, yet it remains poorly understood at the molecular level. Here we report the results of an extensive density functional theory study in which the initial stages of NaCl ...
Angelos Michaelides, David R. Bowler, Jiří Klimeš, Wales D. J.   +3 more
core   +2 more sources

Effect of Soil Organic Matter, Soil pH, and Moisture Content on Solubility and Dissolution Rate of CuO NPs in Soil.

Environmental Science and Technology, 2019
The objectives of this research were to quantify the impact of organic matter content, soil pH and moisture content on the dissolution rate and solubility of copper oxide nanoparticles (CuO NPs) in soil, and to develop an empirical model to predict the ...
Xiaoyu Gao, S. Rodrigues, Eleanor Spielman-Sun, Sónia P. Lopes, Sandra Rodrigues, Yilin Zhang, A. Avellan, R. M. Duarte, A. Duarte, Elizabeth A. Casman, G. Lowry   +10 more
semanticscholar   +1 more source

The role and reasons for the dissolution of Parliament in the countries of the region [PDF]

Zbornik Radova Pravnog Fakulteta u Nišu, 2019
Establishing a balance between the legislative and the executive power, including the presence of constitutional mechanisms of mutual control, is an essential feature of parliamentarism.
Pilipović Milan
doaj  

Effective collection of volatile organic compounds in water using rimming flow with odorant-binding proteins

Mechanical Engineering Journal, 2015
Water solution of volatile organic compounds (VOCs) in air, especially explosive materials, is required to detect VOCs by biosensors efficiently. We developed a collecting device like olfactory mechanism of animals: thin film of water including odorant ...
Hitoshi KIDA, Satoshi TSUKADA, Yoshiyuki TAGAWA, Ryoichi SATO, Masaharu KAMEDA   +4 more
doaj   +1 more source

First-Principles and Empirical Approaches to Predicting In Vitro Dissolution for Pharmaceutical Formulation and Process Development and for Product Release Testing

AAPS Journal, 2019
This manuscript represents the perspective of the Dissolution Working Group of the International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) and of two focus groups of the American Association of Pharmaceutical Scientists ...
N. Zaborenko, Zhenqi Shi, Claudia C. Corredor, Brandye Smith-Goettler, Limin Zhang, Andre Hermans, C. Neu, Md Anik Alam, Michael J. Cohen, Xujin Lu, Leah Xiong, Brian M. Zacour   +11 more
semanticscholar   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Partitioning and Dissolution Behavior of Metal-based Engineered Nanoparticles in Sediment and Soil Suspensions

E3S Web of Conferences, 2013
Nowadays engineered nanoparticles are being used in a whole range of commercial applications and are therefore expected to inevitably find their way into the environment where their fate and behavior are still largely unknown. The objective of this study
Koetsem F. Van, Laing G. Du
doaj   +1 more source

On the Mechanism of the Dissolution of Quartz and Silica in Aqueous Solutions

ACS Omega, 2017
Quartz and silica are common materials, and their dissolution is of significant interest to a wide range of scientists. The kinetics of the dissolution of quartz and silica have been measured extensively, yet no clear theory of dissolution is available ...
F. Crundwell
semanticscholar   +1 more source