Results 211 to 220 of about 41,703 (248)
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Coamorphous repaglinide–saccharin with enhanced dissolution
International Journal of Pharmaceutics, 2013Recently, coamorphous systems composed of two drugs or a drug and a small molecule excipient, gained interests due to their ability in overcoming limitations associated with solid dispersions. In this study, coamorphous form of repaglinide (REP), a BCS class II anti-diabetic drug with low aqueous solubility and high permeability was achieved with ...
Yuan, Gao +3 more
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Dissolution enhancement of tadalafil by liquisolid technique
Pharmaceutical Development and Technology, 2016This study aimed to enhance the dissolution of tadalafil, a poorly water-soluble drug by applying liquisolid technique. The effects of two critical formulation variables, namely drug concentration (17.5% and 35%, w/w) and excipients ratio (10, 15 and 20) on dissolution rates were investigated. Pre-compression tests, including particle size distribution,
Mei, Lu +6 more
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Use of Adsorbents in Enhancement of Drug Dissolution I
Journal of Pharmaceutical Sciences, 1972A new approach is described for increasing the dissolution rates of relatively insoluble powders. It is based on the concept of increasing the surface available for contact with dissolution media. This is accomplished by equilibration of the drug in an organic solvent (e.g., acetone) on an insoluble excipient with an extensive surface (e.g., fumed ...
D C, Monkhouse, J L, Lach
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Studies in Dissolution Enhancement of Nifedipine
Drug Development and Industrial Pharmacy, 1996AbstractSolid dispersions containing PVP and PEG, inclusion complex with beta cyclodextrin (Bcyd), and kneaded mixtures with hydrophilic adjuvants such as water-soluble gelatin (WSG) and microcrystalline cellulose (MCC) were prepared in order to enhance the dissolution rate of nifedipine (NF) in simulated gastric fluid.
M. C. Gohel, M. R. Patel, K. V. Patel
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Enhancement of solid dissolution by ultrasound
Chemical Engineering and Processing: Process Intensification, 2007Abstract The ultrasonic enhancement of the reduction of dissolved ferric iron (Fe 3+ ) to ferrous iron (Fe 2+ ) with sphalerite (zinc sulfide) concentrate in a sulfuric acid solution, which is an industrially important reaction in zinc production, was studied. The temperature of the experiments varied between 75 °C and 95 °C.
Henrik Grénman +7 more
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Mechanical enhancement of the dissolution of ilmenite
Minerals Engineering, 1998Abstract An ilmenite concentrate has been ball milled for up to 100 h in a laboratory mill without any evidence of a phase change. The particle size reached steady-state within 10 h of milling with a concomitant maximum in the BET surface area. There was considerable damage to the crystal lattice with a decrease in the crystallite size which was a ...
N.J. Welham, D.J. Llewellyn
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Dissolution and bioavailability enhancement of glyburide
Toxicological & Environmental Chemistry, 2013The solubility behavior of drug is one of the most challenging aspects in formulation development, as dissolution and absorption behaviors depend upon this property. The objective of this study was to improve the solubility, dissolution rate, and bioavailability of a poor water-soluble oral hypoglycemic drug glyburide by forming a fast disintegrating ...
Srinivas Reddy Devireddy +1 more
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Enhancement of solid dissolution process
Chemical Engineering Journal, 2004The enhancement of the dissolution rate of the sparingly soluble benzoic acid in aqueous solution by solid rotation, ultrasound and chemical reaction was investigated. The analysis indicated the strong influence of the ultrasound energy dissipation rate on the enhancement. The overall enhancements due to the three means were compared.
A Kannan, Sadhi Khan Pathan
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AAPS PharmSciTech, 2017
Efavirenz is a fundamental drug in the HIV therapy; however, it has a low bioavailability due to low water solubility. Particle nanonization should enhance its dissolution and therefore its bioavailability. Nanocrystallization is a promising technique for preparing drug nanocrystals.
Gabriela Julianelly, Sartori +2 more
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Efavirenz is a fundamental drug in the HIV therapy; however, it has a low bioavailability due to low water solubility. Particle nanonization should enhance its dissolution and therefore its bioavailability. Nanocrystallization is a promising technique for preparing drug nanocrystals.
Gabriela Julianelly, Sartori +2 more
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Prodrug Approach to Enhancement of Rate of Dissolution of Allopurinol
Journal of Pharmaceutical Sciences, 1974The synthesis and physicochemical characteristics of l-ethoxyethyI-4-allopurinyl ether and 2-tetrahydropyranyl-4-allo- purinyl ether are described. These compounds have lower melting points, higher solubilities, and, consequently, considerably greater rates of dissolution than does allopurinol. The rate of hydrolysis of the ethyl vinyl ether derivative
A, Hussain, J H, Rytting
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