Results 41 to 50 of about 56,903 (208)
Alternative oral exemestane formulation: Improved dissolution and permeation
International Journal of Pharmaceutics, 2010 Exemestane (EXE) is an irreversible aromatase inactivator used for the treatment of advanced postmenopausal breast cancer. EXE is orally active but its bioavailability is about 5% due to its low solubility in water and the extensive first pass effect. It is known that cyclodextrin (CD) complexation enhances solubility and oral bioavailability of poorly
Yavuz, Burcin +3 more
openaire +3 more sources
Improvement of Dissolution and Hypoglycemic Efficacy of Glimepiride by Different Carriers [PDF]
AAPS PharmSciTech, 2012 Effects of tromethamine (Tris), polyvinylpyrrolidone (PVP-K25), and low molecular weight chitosan (LM-CH) on dissolution and therapeutic efficacy of glimepiride (Gmp) were investigated using physical mixtures (PMs), coground mixtures, coprecipitates (Coppts) or kneaded mixtures (KMs), and compared with drug alone.
Elham A, Mohamed +3 more
openaire +2 more sources
Petroleum Exploration and Development, 2023 The element geochemical characteristics and diagenetic alteration products of tuffaceous components in sandstone reservoirs of Paleogene Wenchang Formation in typical subsags of the Huizhou-Lufeng area of the Zhu I Depression, Pearl River Mouth Basin ...
Zihao JIN +6 more
doaj +1 more source
An Approach for Improvement of the Dissolution Rate of Gliclazide
Dissolution Technologies, 2009 Gliclazide is an anti-diabetic drug that is poorly soluble in water. This paper describes an approach to improve the dissolution rate of gliclazide by using solid dispersions (SDs) in polyethylene glycol 4000 (PEG 4000). The phase-solubility behavior of gliclazide in the presence of various concentrations of PEG 4000 in 0.1 N HCl at 37 °C was obtained.
Sudarsan Biswal +3 more
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Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach [PDF]
Pharmaceutics, 2020 In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and
Xavier Buol +6 more
openaire +6 more sources
Improvement of Dissolution in the SOLIDprep Sampler by Ultrasonics
Journal of AOAC INTERNATIONAL, 1973 Abstract This paper describes a novel device which is capable of disintegrating and homogenizing tablets within a very short time and with a minimum of investment. The modification on the existing SOLIDprep Sampler I can be performed in-house. An increase of assay efficiency of at least 50% was observed when these modifications were made.
Maria Lin +2 more
openaire +1 more source
A systematic investigation of secondary phase dissolution in Mg–Sn alloys
Journal of Magnesium and Alloys, 2019 As-cast Mg–Sn alloys (3, 6, and 9 wt% Sn) were solution treated at 653, 703 and 753 K (380, 430 and 480 °C) for 1, 4, 8, 12 and 24 h to determine the variation of secondary phase with respect to Sn content, temperature and time.
Arushi Dev +4 more
doaj +1 more source
Cavitation-assisted decontamination of yttria from graphite of different densities
Ultrasonics Sonochemistry, 2021 Yttria coated graphite crucibles are widely used to handle molten refractory and radioactive metals like uranium and plutonium. However, the coated layer suffers damages like cracking and peeling off owing to thermal cycles.
S. Lahiri +4 more
doaj +1 more source
Cristais ocos como estratégia para o incremento a velocidade de dissolução de fármacos pouco solúveis [PDF]
, 2013 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2013.Fármacos pouco solúveis apresentam limitações na biodisponibilidade devido à baixa solubilidade e ...
Paulino, Amarílis Scremin
core
Improvement of Albendazole Dissolution by Preparing Microparticles Using Spray-Drying Technique
, 2007 The aim of this work was to improve the dissolution rate of albendazole (ABZ) by preparing its microparticles with certain hydrophilic polymers such as hydroxypropyl methylcellulose (HPMC), polyvinyl alcohol (PVA), and polyvinyl pyrrolidone (PVP) using ...
Ibrahim A. Alsarra +3 more
core +1 more source