Results 41 to 50 of about 2,889,262 (312)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A systematic investigation of secondary phase dissolution in Mg–Sn alloys

Journal of Magnesium and Alloys, 2019
As-cast Mg–Sn alloys (3, 6, and 9 wt% Sn) were solution treated at 653, 703 and 753 K (380, 430 and 480 °C) for 1, 4, 8, 12 and 24 h to determine the variation of secondary phase with respect to Sn content, temperature and time.
Arushi Dev, Niladri Naskar, Nishant Kumar, Ashutosh Jena, Manas Paliwal   +4 more
doaj   +1 more source

Differences of tuffaceous components dissolution and their impact on physical properties in sandstone reservoirs: A case study on Paleogene Wenchang Formation in Huizhou-Lufeng area, Zhu I Depression, Pearl River Mouth Basin, China

Petroleum Exploration and Development, 2023
The element geochemical characteristics and diagenetic alteration products of tuffaceous components in sandstone reservoirs of Paleogene Wenchang Formation in typical subsags of the Huizhou-Lufeng area of the Zhu I Depression, Pearl River Mouth Basin ...
Zihao JIN, Guanghui YUAN, Xiangtao ZHANG, Yingchang CAO, Lin DING, Xiaoyan LI, Xiaohan FU   +6 more
doaj   +1 more source

Simulation of rock salt dissolution and its impact on land subsidence [PDF]

, 2014
Extensive land subsidence can occur due to subsurface dissolution of evaporites such as halite and gypsum. This paper explores techniques to simulate the salt dissolution forming an intrastratal karst, which is embedded in a sequence of carbonates, marls,
A. Younes, Younes, A., Zidane, A., Zechner, E., Huggenberger, P., P. Huggenberger, A. Zidane, E. Zechner   +7 more
core   +2 more sources

Biorelevant Dissolution of Dipyridamole and Piroxicam Using an Automated UV/Vis Spectrophotometric and Potentiometric Dissolution Testing Platform

, 2023
The objective of this study was to investigate the implications of changing dissolution parameters, including pH ramp time, absence and presence of simulated intestinal fluid (SIF), and the addition of a partitioning phase, using an automated dissolution-
Anette Müllertz, Box, Karl, Berthelsen, Ragna, Østergaard, Jesper, Karl Box, Larsen, Susan Weng, Susan Weng Larsen, Jesper Østergaard, Müllertz, Anette, Ragna Berthelsen   +9 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Improved Solubility and Dissolution Rates in Novel Multicomponent Crystals of Piperine with Succinic Acid

Scientia Pharmaceutica, 2020
The objectives of this study were to prepare and characterize a novel piperine–succinic acid multicomponent crystal phase and to evaluate the improvement in the solubility and dissolution rate of piperine when prepared in the multicomponent crystal ...
Erizal Zaini, Afriyani, Lili Fitriani, Friardi Ismed, Ayano Horikawa, Hidehiro Uekusa   +5 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Improvement of Solubility and Dissolution of Niclosamide using Metal Organic Framework 5 (MOF-5)

Iraqi Journal of Pharmaceutical Sciences
Metal-organic frameworks-5 (MOF-5) were explored for enhancement of the solubility and dissolution of the drug niclosamide (NIC). MOF-5 was synthesized by solvothermal method and NIC was loaded into it (NIC@MOF-5).
Hayder Yahya Mansoor Al-Jarsha, Mowafaq M. Ghareeb   +1 more
doaj   +1 more source