Results 51 to 60 of about 2,889,262 (312)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Rivaroxaban solid dispersions for dissolution enhancement and formulation of mouth disintegrating tablets

Journal of Applied Pharmaceutical Research
Background: Work is carried out to improve rivaroxaban's dissolution rate (DR) and develop mouth-disintegrating tablets for rapid onset of action.
Kalki Ranjan Priyadarshan, Asish Sahu, Anjan Kumar Mahapatra, K. A Chowdary, Ajit Nahak, Ruchita Kumari Patra   +5 more
doaj   +1 more source

BOX BEHNKEN MODEL-BASED LIQUISOLID COMPACT TECHNIQUE FOR THE IMPROVEMENT OF SOLUBILITY AND DISSOLUTION RATE OF AZELNIDIPINE [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
The present investigation deals with improving solubility and dissolution rate, thereby achieving greater bioavailability and absorption by the Liquisolid Compact Technique.
Dr. Abhishek Kanugo, Rutik Jukti
doaj   +1 more source

Alternative oral exemestane formulation: Improved dissolution and permeation

International Journal of Pharmaceutics, 2010
Exemestane (EXE) is an irreversible aromatase inactivator used for the treatment of advanced postmenopausal breast cancer. EXE is orally active but its bioavailability is about 5% due to its low solubility in water and the extensive first pass effect. It is known that cyclodextrin (CD) complexation enhances solubility and oral bioavailability of poorly
Yavuz, Burcin, Bilensoy, Erem, Vural, Imran, Sumnu, Murat   +3 more
openaire   +4 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Synthesis, Characterization, and Intrinsic Dissolution Studies of Drug–Drug Eutectic Solid Forms of Metformin Hydrochloride and Thiazide Diuretics

Pharmaceutics, 2021
The mechanochemical synthesis of drug–drug solid forms containing metformin hydrochloride (MET·HCl) and thiazide diuretics hydrochlorothiazide (HTZ) or chlorothiazide (CTZ) is reported.
Guadalupe Coyote-Dotor, José C. Páez-Franco, Daniel Canseco-González, Alejandra Núñez-Pineda, Alejandro Dorazco-González, Inés Fuentes-Noriega, Alfredo R. Vilchis-Néstor, Joelis Rodríguez-Hernández, David Morales-Morales, Juan Manuel Germán-Acacio   +9 more
doaj   +1 more source

Improving Riparin-A Dissolution through a Laponite Based Nanohybrid

Pharmaceutics, 2023
(1) Background: Riparin-A presents several pharmacological activities already elucidated, such as antimicrobial modulator, antileishmania, anxiolytic, anti-inflammatory, antinociceptive, and antioxidant. Even with important bioactive effects, the applicability of Riparin-A is limited due to its low solubility in water, impairing its dissolution in ...
Duanne Mendes Gomes, Lyghia Maria Araújo Meirelles, Paulo Monteiro Araujo, Rayran Walter Ramos de Sousa, Paulo Michel Pinheiro Ferreira, Stanley Juan Chavez Gutierrez, Maria das Graças Freire de Medeiros, Fernanda Nervo Raffin   +7 more
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

In vitro dissolution study of atorvastatin binary solid dispersion

Journal of Advanced Pharmaceutical Technology & Research, 2013
The aim of the present study was to improve the solubility and dissolution rate of atorvastatin (ATV), a slight water-soluble drug, by solid dispersion (SD) technique using a hydrophilic carrier Poloxamer 188 (POL188).
Rahat Jahan, Md. Saiful Islam, Ahmad Tanwir, Jakir Ahmed Chowdhury   +3 more
doaj   +1 more source

Dissolution Stability Study of Cefadroxil Extemporaneous Suspensions [PDF]

, 2008
Dissolution studies have become matter of great significance because, in most cases, drug dissolution is the rate-limiting step in the absorption process.
Noelia L. Gonzalez Vidal, González Vidal, Noelia Luján, Simionato, Laura Daniela, Patricia D. Zubata, Maria T. Pizzorno, Pizzorno, Maria Teresa, Laura D. Simionato, Zubata, P. D., Noelia L. Gonzalez Vidal   +8 more
core   +1 more source