Results 51 to 60 of about 56,903 (208)

Improvement of solubility and dissolution rate of poorly water-soluble salicylic acid by a spray-drying technique

, 1975
Spray drying techniques have been applied to improve the solubility and dissolution rate of poorly water-soluble salicylic acid. Spray drying of the acid dispersed in acacia solutions resulted in as much as a 50% improvement in the solubility of the ...
H Takenaka, M Saito, Y Kawashima
core   +1 more source

Improved Solubility and Dissolution Rates in Novel Multicomponent Crystals of Piperine with Succinic Acid

Scientia Pharmaceutica, 2020
The objectives of this study were to prepare and characterize a novel piperine–succinic acid multicomponent crystal phase and to evaluate the improvement in the solubility and dissolution rate of piperine when prepared in the multicomponent crystal ...
Erizal Zaini, Afriyani, Lili Fitriani, Friardi Ismed, Ayano Horikawa, Hidehiro Uekusa   +5 more
doaj   +1 more source

Rivaroxaban solid dispersions for dissolution enhancement and formulation of mouth disintegrating tablets

Journal of Applied Pharmaceutical Research
Background: Work is carried out to improve rivaroxaban's dissolution rate (DR) and develop mouth-disintegrating tablets for rapid onset of action.
Kalki Ranjan Priyadarshan, Asish Sahu, Anjan Kumar Mahapatra, K. A Chowdary, Ajit Nahak, Ruchita Kumari Patra   +5 more
doaj   +1 more source

BOX BEHNKEN MODEL-BASED LIQUISOLID COMPACT TECHNIQUE FOR THE IMPROVEMENT OF SOLUBILITY AND DISSOLUTION RATE OF AZELNIDIPINE [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
The present investigation deals with improving solubility and dissolution rate, thereby achieving greater bioavailability and absorption by the Liquisolid Compact Technique.
Dr. Abhishek Kanugo, Rutik Jukti
doaj   +1 more source

Dissolution and bioavailability improvement of bioactive apigenin using solid dispersions prepared by different techniques

, 2019
Apigenin (APG) is a poorly soluble bioactive compound/nutraceutical which shows poor bioavailability upon oral administration. Hence, the objective of this research work was to develop APG solid dispersions (SDs) using different techniques with the ...
Mohammad Altamimi, Ibrahim A. Alsarra, Musaed Alkholief, Mohamed A. Ibrahim, Osaid T. Almeanazel, Bader Alsulays, Ehab M. Elzayat, Fars K. Alanazi, Kazi Mohsin, Sultan M. Alshehri, Faiyaz Shakeel, Abdullah Alshetaili   +11 more
core   +1 more source

Synthesis, Characterization, and Intrinsic Dissolution Studies of Drug–Drug Eutectic Solid Forms of Metformin Hydrochloride and Thiazide Diuretics

Pharmaceutics, 2021
The mechanochemical synthesis of drug–drug solid forms containing metformin hydrochloride (MET·HCl) and thiazide diuretics hydrochlorothiazide (HTZ) or chlorothiazide (CTZ) is reported.
Guadalupe Coyote-Dotor, José C. Páez-Franco, Daniel Canseco-González, Alejandra Núñez-Pineda, Alejandro Dorazco-González, Inés Fuentes-Noriega, Alfredo R. Vilchis-Néstor, Joelis Rodríguez-Hernández, David Morales-Morales, Juan Manuel Germán-Acacio   +9 more
doaj   +1 more source

DEVELOPMENT OF NANOCRYSTAL FORMULATION WITH IMPROVED DISSOLUTION

Journal of Drug Delivery and Therapeutics, 2018
With the advancement in modern pharmaceutical technologies, Nanotechnology is the one of the most establish technology which is used to improve the therapeutic index and to overcome the formulation challenges of poorly water-soluble compounds. Nanocrystals, in nano range, is the interesting approach for poorly soluble drugs.
Sandeep Kumar, Jaspreet Kaur Saini
openaire   +2 more sources

Dissolution improvement of high drug-loaded solid dispersion [PDF]

AAPS PharmSciTech, 2006
This study focused on an investigation of a high drug-loaded solid dispersion system consisting of drug, carrier, and surfactant. Solid dispersions of a water-insoluble ofloxacin (OFX) with polyethylene glycol (PEG) of different molecular weights, namely binary solid dispersion systems, were prepared at drug to carrier not less than 5:5. Polysorbate 80,
Siriporn, Okonogi, Satit, Puttipipatkhachorn   +1 more
openaire   +2 more sources

In vitro dissolution study of atorvastatin binary solid dispersion

Journal of Advanced Pharmaceutical Technology & Research, 2013
The aim of the present study was to improve the solubility and dissolution rate of atorvastatin (ATV), a slight water-soluble drug, by solid dispersion (SD) technique using a hydrophilic carrier Poloxamer 188 (POL188).
Rahat Jahan, Md. Saiful Islam, Ahmad Tanwir, Jakir Ahmed Chowdhury   +3 more
doaj   +1 more source

Formulation and In-Vitro Evaluation of Meloxicam Solid Dispersion using Natural Polymers.

Iraqi Journal of Pharmaceutical Sciences, 2021
Meloxicam (MLX) is non-steroidal anti -inflammatory, poorly water soluble, highly permeable drug and the rate of its oral absorption is often controlled by the dissolution rate in the gastrointestinal tract.
Hiba R. Al-Hassani, Eman B. H. Al-Khedairy   +1 more
doaj   +1 more source