Results 71 to 80 of about 261,203 (312)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Effect of surface dissolution by oxalic acid on flotation behavior of minerals

Journal of Materials Research and Technology, 2019
The surface dissolution pretreatment using oxalic acid as an organic agent was applied for modifying the surface properties of minerals and improving the selectivity of ilmenite flotation from its usual accompanied gangue minerals such as olivine ...
Omid Salmani Nuri, Mehdi Irannajad, Akbar Mehdilo   +2 more
doaj   +1 more source

A New Challenge for the Old Excipient Calcium Carbonate: To Improve the Dissolution Rate of Poorly Soluble Drugs

Pharmaceutics, 2023
Calcium carbonate is an excipient traditionally used in solid dosage forms with several functions such as a diluent, a quick dissolution agent, a buffer and an opacifier.
Valeria Ambrogi
doaj   +1 more source

D 5.4.1.3. Final Report on sensory testing in Europe for Group 3. Project AFTER “African Food Tradition rEvisited by Research” [PDF]

, 2015
The work presented in this deliverable had as main objective the sensory profiling of products resulting from process reengineering of traditional products from group 3 − plant based extracts.
Bechoff, Aurélie, Boucher, Mathilde, Cissé, M., Costa, Ana Isabel A., Fliedel, Geneviève, Maraval, Isabelle, Monteiro, Maria Joao, Pallet, Dominique, Pintado, Maria Manuela E., Pintado, Maria Manuela E., Tomlins, Keith I.   +10 more
core  

Lime stabilisation for earthworks: a UK perspective [PDF]

, 2014
Lime stabilisation is a versatile technique applied during earthworks operations. Modern soil recycling units are much more efficient at pulverising fill material and intermixing the added binder/water than machinery available 20 years ago.
Beetham P, Bell FG, Bergado DT, Bin S, Bohn HL, BSI, BSI, BSI, Davidson LK, Diamond S, Eades JE, Greaves HM, Highways Agency, Highways Agency, Highways Agency, Holt CC, Ingles OG, John Bateman, Longworth I, McAllister LD, Mitchell JK, Neil Dixon, Paul Beetham, Paul Fleming, Perry J, Petry TM, Reeves GM, Robert Hutchison, Rowell DL, Sherwood PT, Sherwood PT, Snedker EA, Stocker PT, Sweeney DA, Taylor HFW, Tom Dijkstra, Van Olphen H, Winter NB   +37 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Solubility and Dissolution Rate Enhancement of Bilastine by Solid Dispersion Technique

Iraqi Journal of Pharmaceutical Sciences
Bilastine (BLS) is non-sedating new-brand H1 antihistamine that has selective peripheral effects, the drug has a problem of an insufficient aqueous solubility and accordingly low dissolution rate, and low bioavailability. Solid dispersion (SD) is one of
Mariam Hamid Ali, Kawther Khalid Ahmed
doaj   +1 more source

Equilibrium solubility versus intrinsic dissolution: characterization of lamivudine, stavudine and zidovudine for BCS classification

Brazilian Journal of Pharmaceutical Sciences, 2013
Solubility and dissolution rate of drugs are of major importance in pre-formulation studies of pharmaceutical dosage forms. The solubility improvement allows the drugs to be potential biowaiver candidates and may be a good way to develop more dose ...
André Bersani Dezani, Thaisa Marinho Pereira, Arthur Massabki Caffaro, Juliana Mazza Reis, Cristina Helena dos Reis Serra   +4 more
doaj   +1 more source

A longitudinal analysis of moving desires, expectations and actual moving behaviour [PDF]

, 2015
Residential mobility theory proposes that moves are often preceded by the expression of moving desires and expectations. Much research has investigated how individuals form these premove thoughts, with a largely separate literature examining actual ...
Coulter, Rory Christopher, Feijten, Peteke, Van Ham, Maarten   +2 more
core   +1 more source

Improvement of dissolution rate of indomethacin by inkjet printing

European Journal of Pharmaceutical Sciences, 2015
The aim of this study was to prepare printable inks of the poorly water soluble drug indomethacin (IMC), fabricate printed systems with flexible doses and investigate the effect of ink excipients on the printability, dissolution rate and the solid state properties of the drug.
Henrika, Wickström, Mirja, Palo, Karen, Rijckaert, Ruzica, Kolakovic, Johan O, Nyman, Anni, Määttänen, Petri, Ihalainen, Jouko, Peltonen, Natalja, Genina, Thomas, de Beer, Korbinian, Löbmann, Thomas, Rades, Niklas, Sandler   +12 more
openaire   +3 more sources