Results 61 to 70 of about 2,889,262 (312)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Formulation and In-Vitro Evaluation of Meloxicam Solid Dispersion using Natural Polymers.

Iraqi Journal of Pharmaceutical Sciences, 2021
Meloxicam (MLX) is non-steroidal anti -inflammatory, poorly water soluble, highly permeable drug and the rate of its oral absorption is often controlled by the dissolution rate in the gastrointestinal tract.
Hiba R. Al-Hassani, Eman B. H. Al-Khedairy   +1 more
doaj   +1 more source

An Approach for Improvement of the Dissolution Rate of Gliclazide

Dissolution Technologies, 2009
Gliclazide is an anti-diabetic drug that is poorly soluble in water. This paper describes an approach to improve the dissolution rate of gliclazide by using solid dispersions (SDs) in polyethylene glycol 4000 (PEG 4000). The phase-solubility behavior of gliclazide in the presence of various concentrations of PEG 4000 in 0.1 N HCl at 37 °C was obtained.
Sudarsan Biswal, Gouri S. Pasa, Jagannath Sahoo, Padala N. Murthy   +3 more
openaire   +1 more source

Dissolution of Cavities and Porous Media: a Multi-Scale View [PDF]

, 2013
Dissolution of underground cavities or porous media involves many different scales that must be taken into account in modeling attempts. This paper presents a review of some of these problems.
Quintard, Michel
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Effect of surface dissolution by oxalic acid on flotation behavior of minerals

Journal of Materials Research and Technology, 2019
The surface dissolution pretreatment using oxalic acid as an organic agent was applied for modifying the surface properties of minerals and improving the selectivity of ilmenite flotation from its usual accompanied gangue minerals such as olivine ...
Omid Salmani Nuri, Mehdi Irannajad, Akbar Mehdilo   +2 more
doaj   +1 more source

Improvement of Dissolution in the SOLIDprep Sampler by Ultrasonics

Journal of AOAC INTERNATIONAL, 1973
Abstract This paper describes a novel device which is capable of disintegrating and homogenizing tablets within a very short time and with a minimum of investment. The modification on the existing SOLIDprep Sampler I can be performed in-house. An increase of assay efficiency of at least 50% was observed when these modifications were made.
Maria Lin, William T Brunskill, Tibor Urbányi   +2 more
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Solubility and Dissolution Rate Enhancement of Bilastine by Solid Dispersion Technique

Iraqi Journal of Pharmaceutical Sciences
Bilastine (BLS) is non-sedating new-brand H1 antihistamine that has selective peripheral effects, the drug has a problem of an insufficient aqueous solubility and accordingly low dissolution rate, and low bioavailability. Solid dispersion (SD) is one of
Mariam Hamid Ali, Kawther Khalid Ahmed
doaj   +1 more source