Results 81 to 90 of about 261,203 (312)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Self-nanoemulsifying ramipril tablets: a novel delivery system for the enhancement of drug dissolution and stability

International Journal of Nanomedicine, 2019
Khalid F Alhasani,1 Mohsin Kazi,1,2 Mohamed Abbas Ibrahim,1 Ahmad A Shahba,1,2 Fars K Alanazi1,21Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia; 2Kayyali Chair for Pharmaceutical ...
Alhasani KF, Kazi M, Ibrahim MA, Shahba AA, Alanazi FK   +4 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The photometric evolution of dissolving star clusters: II. Realistic models. Colours and M/L ratios

, 2009
Evolutionary synthesis models are the prime method to construct models of stellar populations, and to derive physical parameters from observations. One of the assumptions for such models so far has been the time-independence of the stellar mass function.
Alvensleben, Alvensleben, Alvensleben, Alvensleben, Alvensleben, Alvensleben, Bastian, Baumgardt, Baumgardt, Bertelli, Bertelli, Boutloukos, Bruzual, Cariulo, Cerviño, Cerviño, Cerviño, Charbonnel, Chen, Dabringhausen, de Grijs, de Grijs, Fagiolini, Fioc, Gieles, Gieles, Gieles, Gieles, Giersz, Gill, Girardi, Goodwin, Gouliermis, H. Baumgardt, H. J. G. L. M. Lamers, Harris, Henon, Hurley, Hurley, Kalirai, Kassin, Kotulla, Kroupa, Kruijssen, Kruijssen, Kundu, Küpper, Lada, Lamers, Lamers, Lamers, Larsen, Larsen, Leitherer, Lejeune, Lejeune, Maccarone, Maraston, Marigo, Marks, McLaughlin, Mieske, Mieske, Nomoto, Odenkirchen, P. Anders, Pietrinferni, Pietrinferni, Rejkuba, Salpeter, Schaerer, Schaller, Smith, Spitzer, Tinsley, Tinsley, Tinsley, Weidemann, Weidemann, Worthey, Yi   +80 more
core   +1 more source

Effects Of Attenuation And Thrombus Age On The Success Of Ultrasound And Microbubble-Mediated Thrombus Dissolution [PDF]

, 2011
The purpose of this study was to examine the effects of applied mechanical index, incident angle, attenuation and thrombus age on the ability of 2-D vs. 3-D diagnostic ultrasound and microbubbles to dissolve thrombi.
Drvol, L. K., Everbach, E. Carr, Gao, S. J., Lof, J., Porter, T. R., Powers, J. E., Shi, W. T., Vignon, F., Xie, F.   +8 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Detailed plan for the COMET WP3 initial research activity - list of research projects and goals, participants and timing [PDF]

, 2013
Detailed plan for the COMET Work Package (WP ...
Barnett, Catherine L., Beresford, Nick, Bradshaw, Clare, Brown, Justin, Calmon, Philippe, Chmielewka, Izabela, Duffa, Céline, Fevrier, Laureline, Gaschak, Sergey, Iosjpe, Mikhail, Kaspparov, Valery, Lahtinen, Juhani, Liland, Astrid, Michalik, Boguslaw, Mora Candas, Juan Carlos, Nanbu, Kenji, Outola, Iisa, Real, Almudena, Robles, Beatriz, Salbu, Brit, Simon-Cornu, Marie, Skipperud, L., Stark, Karolina, Steiner, Martin, Thorring, Håvard, Vandenhove, Hildegarde, Vanhoudt, Nathalie, Vives i Battle, Jordi   +27 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Improvement of Dissolution Test Using Micro-controlled Roller Pump

YAKUGAKU ZASSHI, 2012
The dissolution test is a core performance test in pharmaceutical development and quality control of solid drug products. The conventional HPLC dissolution method (batch-sampling method) involves many steps including the filtration, collection and replenishment of sample solutions.
Noriaki, Nagai, Nahoko, Konishi, Tadahisa, Nitta, Atsushi, Taga, Yoshimasa, Ito   +4 more
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source