Results 21 to 30 of about 2,889,262 (312)
Pharmaceuticals, 2023 In this present research, an attempt has been made to address the influence of drug-coformer stoichiometric ratio on cocrystal design and its impact on improvement of solubility and dissolution, as well as bioavailability of poorly soluble telmisartan ...
Manami Dhibar +7 more
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The Effect of Tween 20, 60, and 80 on Dissolution Behavior of Sprionolactone in Solid Dispersions Prepared by PEG 6000 [PDF]
Advanced Pharmaceutical Bulletin, 2015 Purpose: Solid dispersions have been efficient in improving the dissolution rate and bioavailability of hydrophobic drugs. The aim of the present study was enhancement of the dissolution profile of Spironolactone using solid dispersion.
Jafar Akbari +6 more
doaj +1 more source
Nanotechnology Versus other Techniques in Improving Drug Dissolution [PDF]
Current Pharmaceutical Design, 2014 Many newly discovered drug molecules have low aqueous solubility, which results in low bioavailability. One way to improve their dissolution is to formulate them as nanoparticles, which have high specific surface areas, consequently increasing the dissolution rate and solubility. Nanoparticles can be produced via top-down or bottom-up methods. Top-down
Kwok, PCL, Chan, HK
openaire +4 more sources
Preparation and characterization of domperidone nanoparticles for dissolution improvement
Iraqi Journal of Pharmaceutical Sciences, 2018 This study was carried out to prepare and characterize domperidone nanoparticles to enhance solubility and the release rate. Domperidone is practically insoluble in water and has low and an erratic bioavailability range from 13%-17%.
Mohammed Sabar Al-lami +2 more
doaj +1 more source
Dual-barrel conductance micropipet as a new approach to the study of ionic crystal dissolution kinetics [PDF]
, 2013 A new approach to the study of ionic crystal dissolution kinetics is described, based on the use of a dual-barrel theta conductance micropipet. The solution in the pipet is undersaturated with respect to the crystal of interest, and when the meniscus at ...
Massimo Peruffo +11 more
core +1 more source
Preparation And Characterization Of Nimesulide Nanoparticles For Dissolution Improvement
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2018 Nimesulide is one of the types of non-steroidal anti-inflammatory drugs, widely used as analgesic and antipyretic. It is classified as class II drugs according to BCS guidance because of low solubility in water that leads to decrease in dissolution rate.
Inas F. Abd-AlRazaq +2 more
doaj +1 more source
Pharmaceutics, 2022 Estimating the dissolution behavior of a solid in the nasal mucus is challenging for solid dosage forms designed for the nasal application as the solid dissolves into nasal mucus and permeates through the mucosa.
Daisuke Inoue +2 more
doaj +1 more source
Improved Formazan Dissolution for Bacterial MTT Assay
Microbiology Spectrum, 2021 Reduction of the water-soluble tetrazolium salt 3-(4,5-dimethylthiazol)-2,5 diphenyl-tetrazolium bromide (MTT) to purple, water-insoluble formazan is commonly used for assessment of cell viability and proliferation. Spectrophotometric detection of formazan requires its solubilization.
openaire +4 more sources
Role of Solvents in Improvement of Dissolution Rate of Drugs: Crystal Habit and Crystal Agglomeration [PDF]
Advanced Pharmaceutical Bulletin, 2015 Crystallization is often used for manufacturing drug substances. Advances of crystallization have achieved control over drug identity and purity, but control over the physical form remains poor.
Maryam Maghsoodi
doaj +1 more source
PharmaceuticsBackground/Objectives: Selective laser sintering (SLS) is one of the most promising 3D printing techniques for pharmaceutical applications as it offers numerous advantages, such as suitability to work with already approved pharmaceutical excipients, the ...
Nikola Pešić +5 more
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