Results 21 to 30 of about 261,203 (312)
Acta Pharmaceutica, 2016 The dissolution rate of anhydrous acyclovir was improved by the preparation of physical mixtures and solid dispersions with the non-ionic polymer Pluronic F127 using the kneading method at different drug-to-polymer ratios.
Karolewicz Bożena +3 more
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The dissolution and solid-state behaviours of coground ibuprofen–glucosamine HCl [PDF]
, 2014 The cogrinding technique is one of most effective methods for improving the dissolution of poorly water-soluble drugs and it is superior to other approaches from an economical as well as an environmental standpoint, as the technique does not require any ...
Ali Nokhodchi +8 more
core +1 more source
Improvement of Dissolution Test Using Microdialysis Method
YAKUGAKU ZASSHI, 2009 Dissolution testing is a core performance test in pharmaceutical development and quality control. Generally, the HPLC method uses the analysis of dissolution testing. In this study, we attempted to improve the dissolution test by using microdialysis methods. We also investigated the comparison of the conventional HPLC dissolution method (batch-sampling
Noriaki, Nagai +2 more
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The Effect of Tween 20, 60, and 80 on Dissolution Behavior of Sprionolactone in Solid Dispersions Prepared by PEG 6000 [PDF]
Advanced Pharmaceutical Bulletin, 2015 Purpose: Solid dispersions have been efficient in improving the dissolution rate and bioavailability of hydrophobic drugs. The aim of the present study was enhancement of the dissolution profile of Spironolactone using solid dispersion.
Jafar Akbari +6 more
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The role of phospholipid as a solubility- and permeability-enhancing excipient for the improved delivery of the bioactive phytoconstituents of Bacopa monnieri [PDF]
, 2016 In an attempt to improve the solubility and permeability of Standardized Bacopa Extract (SBE), a complexation approach based on phospholipid was employed.
Bobde, Yamini S +6 more
core +2 more sources
Alternative oral exemestane formulation: Improved dissolution and permeation
International Journal of Pharmaceutics, 2010 Exemestane (EXE) is an irreversible aromatase inactivator used for the treatment of advanced postmenopausal breast cancer. EXE is orally active but its bioavailability is about 5% due to its low solubility in water and the extensive first pass effect. It is known that cyclodextrin (CD) complexation enhances solubility and oral bioavailability of poorly
Yavuz, Burcin +3 more
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Pharmaceutics, 2022 Estimating the dissolution behavior of a solid in the nasal mucus is challenging for solid dosage forms designed for the nasal application as the solid dissolves into nasal mucus and permeates through the mucosa.
Daisuke Inoue +2 more
doaj +1 more source
Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach [PDF]
Pharmaceutics, 2020 In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and
Xavier Buol +6 more
openaire +7 more sources
Preparation and characterization of domperidone nanoparticles for dissolution improvement
Iraqi Journal of Pharmaceutical Sciences, 2018 This study was carried out to prepare and characterize domperidone nanoparticles to enhance solubility and the release rate. Domperidone is practically insoluble in water and has low and an erratic bioavailability range from 13%-17%.
Mohammed Sabar Al-lami +2 more
doaj +1 more source
Role of Solvents in Improvement of Dissolution Rate of Drugs: Crystal Habit and Crystal Agglomeration [PDF]
Advanced Pharmaceutical Bulletin, 2015 Crystallization is often used for manufacturing drug substances. Advances of crystallization have achieved control over drug identity and purity, but control over the physical form remains poor.
Maryam Maghsoodi
doaj +1 more source