Results 1 to 10 of about 2,889,262 (312)
IMPROVEMENT OF DISSOLUTION BEHAVIOR OF TEMAZEPAM [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 1991 The interaction between temazepam and b-cyclodextrin (b-CD) or hydroxypropyl b-cyclodextrin (HPb-CD) was studied in aqueous solution. The attempts made to obtain temazepam-cyclodextrin complexes in the solid state through freeze drying or slow ...
J. Aiache, S. Ahmed, S. Saleh
doaj +2 more sources
Co-amorphization for solubility and dissolution rate improvement: the case of low-crystallization-tendency drugs [PDF]
Saudi Pharmaceutical JournalPoor aqueous solubility and limited oral bioavailability remain major challenges in drug development. Although amorphous forms can improve solubility and dissolution, their physical stability is often compromised by recrystallization.
Arif Budiman +10 more
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Pharmaceutics, 2023 The combination of statins and fibrates in the treatment of lipid abnormalities effectively regulates individual lipid fraction levels. In this study, the screening and assessment of the physicochemical properties of simvastatin-fenofibrate solid ...
Agata Górniak +4 more
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Design and Optimization of Lornoxicam Dispersible Tablets Using Quality by Design (QbD) Approach
Pharmaceuticals, 2022 The present study aims to design and optimize the lornoxicam dispersible tablet (LXDT) formulation using the Quality by design (QbD) approach. A randomized Box–Behnken experimental design was used to characterize the effect of the critical factors, such ...
Nawaf Almotairi +3 more
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Pharmaceutics, 2022 Two active pharmaceutical ingredients (APIs) with limited solubility, simvastatin and ezetimibe, prepared as a drug-drug solid dispersion (SD) was evaluated for physicochemical, microstructural, and aqueous dissolution properties.
Agata Górniak +4 more
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Liquisolid Systems to Improve the Dissolution of Furosemide [PDF]
Scientia Pharmaceutica, 2010 A liquisolid system has the ability to improve the dissolution properties of poorly water soluble drugs. Liquisolid compacts are flowing and compactable powdered forms of liquid medications. The aim of this study was to enhance the in vitro dissolution properties of the practically water insoluble loop diuretic furosemide, by utilising liquisolid ...
Akinlade, Babatunde +3 more
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Isostructural cocrystals of metaxalone with improved dissolution characteristics
RSC Advances, 2021 Metaxalone forms isostructural cocrystals with nicotinamide and salicylamide that offer a solubility advantage compared to the native drug. A drug–drug homosynthon is retained in all the cocrystal structures.
Sunil Kumar Gohel +5 more
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Improving Dissolution and Cytotoxicity by Forming Multidrug Crystals [PDF]
Molecules, 2020 Both rosiglitazone and metformin have effects on blood glucose regulation and the proliferation of liver cancer cells. Combination therapy with these two drugs is common and effective for the treatment of diabetes in the clinic, however, the application of these two drugs is influenced by the poor dissolution of rosiglitazone and the gastrointestinal ...
Bian, Xufei +7 more
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Molecules, 2020 Background: Bioactive oils of natural origin have gained huge interests from health care professionals and patients. Objective: To design a bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS) comprising curcumin (CUR) and piperine (PP) by ...
Mohsin Kazi +5 more
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Pharmaceutical co-crystals of posaconazole for improvement of physicochemical properties [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2022 Posaconazole exerts an extended spectrum of antifungal activity against various strains of clinically relevant moulds and yeasts. In recent years, antifungal triazole posaconazole has become increasingly important for the prophylaxis and treatment of ...
Monika Nijhawan +4 more
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