Results 1 to 10 of about 261,203 (312)
Pharmaceutics, 2022 Two active pharmaceutical ingredients (APIs) with limited solubility, simvastatin and ezetimibe, prepared as a drug-drug solid dispersion (SD) was evaluated for physicochemical, microstructural, and aqueous dissolution properties.
Agata Górniak +4 more
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Pharmaceutics, 2023 The combination of statins and fibrates in the treatment of lipid abnormalities effectively regulates individual lipid fraction levels. In this study, the screening and assessment of the physicochemical properties of simvastatin-fenofibrate solid ...
Agata Górniak +4 more
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Design and Optimization of Lornoxicam Dispersible Tablets Using Quality by Design (QbD) Approach
Pharmaceuticals, 2022 The present study aims to design and optimize the lornoxicam dispersible tablet (LXDT) formulation using the Quality by design (QbD) approach. A randomized Box–Behnken experimental design was used to characterize the effect of the critical factors, such ...
Nawaf Almotairi +3 more
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Road and bridge construction across gypsum karst in England [PDF]
, 2002 Gypsum karst problems in the Permian and Triassic sequences of England have caused difficult conditions for bridge and road construction. In Northern England, the Ripon Bypass crosses Permian strata affected by active gypsum karst and severe subsidence ...
Anthony H Cooper +20 more
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Improving Dissolution and Cytotoxicity by Forming Multidrug Crystals [PDF]
Molecules, 2020 Both rosiglitazone and metformin have effects on blood glucose regulation and the proliferation of liver cancer cells. Combination therapy with these two drugs is common and effective for the treatment of diabetes in the clinic, however, the application of these two drugs is influenced by the poor dissolution of rosiglitazone and the gastrointestinal ...
Bian, Xufei +7 more
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Pharmaceutical co-crystals of posaconazole for improvement of physicochemical properties [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2022 Posaconazole exerts an extended spectrum of antifungal activity against various strains of clinically relevant moulds and yeasts. In recent years, antifungal triazole posaconazole has become increasingly important for the prophylaxis and treatment of ...
Monika Nijhawan +4 more
doaj +1 more source
Pharmaceutics, 2020 The aim of this work was to evaluate the effectiveness of mesoporous clays or silicas to develop fast-dissolving glyburide tablets based on a liquisolid approach.
Marzia Cirri +3 more
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Nanotechnology Versus other Techniques in Improving Drug Dissolution [PDF]
Current Pharmaceutical Design, 2014 Many newly discovered drug molecules have low aqueous solubility, which results in low bioavailability. One way to improve their dissolution is to formulate them as nanoparticles, which have high specific surface areas, consequently increasing the dissolution rate and solubility. Nanoparticles can be produced via top-down or bottom-up methods. Top-down
Kwok, PCL, Chan, HK
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Cellulose Dissolution in Ionic Liquid under Mild Conditions: Effect of Hydrolysis and Temperature
Fibers, 2021 This study investigated the effect of acid hydrolysis of cellulose on its dissolution under mild conditions in ionic liquid, 1-butyl-3-methylimidazolium acetate/N,N-dimethylacetamide (BMIMAc/DMAc).
Sanjit Acharya +2 more
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Improved Formazan Dissolution for Bacterial MTT Assay
Microbiology Spectrum, 2021 Reduction of the water-soluble tetrazolium salt 3-(4,5-dimethylthiazol)-2,5 diphenyl-tetrazolium bromide (MTT) to purple, water-insoluble formazan is commonly used for assessment of cell viability and proliferation. Spectrophotometric detection of formazan requires its solubilization.
openaire +4 more sources