Results 101 to 110 of about 136,291 (302)
Orally administered weakly basic compounds like aripiprazole (ARI) can precipitate in the small intestine due to limited solubility at intestinal pH.
Dobričić, Vladimir +5 more
core +1 more source
Development and Application of Carbonate Dissolution Test Equipment under Thermal-Hydraulic-Chemical Coupling Condition. [PDF]
Materials (Basel), 2022 Meng J, Chen S, Wang J, Chen Z, Zhang J.
europepmc +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Long-term stability of clopidogrel solid dispersions-Importance of in vitro dissolution test. [PDF]
PLoS One, 2022 Osmanović Omerdić E +6 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective Despite well‐described biologic causes, the public views unhealthy lifestyle choices as the primary cause of gout. This study investigated how causal beliefs about gout influence the public's views about its management. Methods In a randomized study, 201 members of the public viewed one of two 2‐minute videos about gout.
Rachel Murdoch +6 more
wiley +1 more source
Cement-rock interaction : infiltration of a high-pH solution into a fractured granite core
, 2010 Within the framework of the HPF project (Hyperalkaline Plume in Fractured Rock) at the Grimsel Test Site (Switzerland), a small scale core infiltration experiment was performed at the University of Bern.
Mäder, Urs K. +3 more
core +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
The EyeFlowCell: Development of a 3D-Printed Dissolution Test Setup for Intravitreal Dosage Forms. [PDF]
Pharmaceutics, 2021 Auel T +4 more
europepmc +1 more source
The consequences of divorce and splitting up for spatial mobility in the UK
, 2015 Union dissolution is well known to have a disruptive effect on the housing situation of those involved, and often leads to downward moves on the "housing ladder".
Feijten, P., van Ham, M.
core +1 more source