Results 71 to 80 of about 1,822,931 (347)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

New device for protein stabilisation of white wines throughout a continuous flow system

BIO Web of Conferences, 2023
In this work, a selection of food-grade ceramic materials (CM1, CM2) was evaluated in terms of capacity to adsorb pathogenesis-related proteins (PRPs), thus preventing protein haze in bottled white wines.
Parpinello Giuseppina P., Ricci Arianna, Moreno Carolina Pavez, Ragni Luigi, Versari Andrea   +4 more
doaj   +1 more source

Allogeneic Stem Cells Alter Gene Expression and Improve Healing of Distal Limb Wounds in Horses. [PDF]

, 2017
Distal extremity wounds are a significant clinical problem in horses and humans and may benefit from mesenchymal stem cell (MSC) therapy. This study evaluated the effects of direct wound treatment with allogeneic stem cells, in terms of gross, histologic,
Aristizobal, Fabio A, Bledsoe, Andrea, Bohannon-Worsley, Laurie K, Borjesson, Dori L, Clark, Kaitlin C, Davidyan, Arik, Gray, Sarah N, Kol, Amir, LeJeune, Sarah S, Textor, Jamie A, Walker, Naomi J, Woolard, Kevin D   +11 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Relative frequency dynamics and loading of beet necrotic yellow vein virus genomic RNAs during the acquisition by its vector Polymyxa betae

Journal of Virology
The beet necrotic yellow vein virus (BNYVV) is a multipartite virus with the highest number (up to five) of genomic segments among RNA viruses. Classified as a soil-borne virus, it is persistently transmitted by the protozoan Polymyxa betae.
Yi Guo, Mattia Dall'Ara, David Baldo, David Gilmer, Claudio Ratti   +4 more
doaj   +1 more source

A Review of the Effect of Formic Acid and Its Salts on the Gastrointestinal Microbiota and Performance of Pigs

Animals, 2020
Out of the alternatives to antibiotics and zinc oxide, organic acids, or simply acidifiers, play significant roles, especially in ensuring gut health and the growth performance of pigs.
Diana Luise, Federico Correa, Paolo Bosi, Paolo Trevisi   +3 more
doaj   +1 more source

Further supporting evidence for REEP1 phenotypic and allelic heterogeneity. [PDF]

, 2019
Heterozygous mutations in REEP1 (MIM #609139) encoding the receptor expression-enhancing protein 1 (REEP1) are a well-recognized and relatively frequent cause of autosomal dominant hereditary spastic paraplegia (HSP), SPG31.1 REEP1 localizes in the ...
Behnam, M, Houlden, H, Kaiyrzhanov, R, Maroofian, R, Salehi, M, Salpietro, V   +5 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

FEBS Open Bio, EarlyView.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey, Lina Riegler‐Berket, Monika Oberer   +2 more
wiley   +1 more source

Real extensions of distal minimal flows and continuous topological ergodic decompositions

, 2012
We prove a structure theorem for topologically recurrent real skew product extensions of distal minimal compact metric flows with a compactly generated Abelian acting group (e.g. $\Z^d$-flows and $\R^d$-flows).
Akin, Atkinson, Auslander, Besicovitch, Bronshtein, de Vries, Egawa, Ellis, Fell, Furstenberg, G. Greschonig, Glasner, Glasner, Glasner, Gottschalk, Greschonig, Holá, Johnson, Keynes, Kuratowski, Lemańczyk, Lemańczyk, Lemańczyk, McMahon, Schmidt   +24 more
core   +1 more source