Results 61 to 70 of about 2,453,855 (317)

Group Leadership in Online Collaborative Learning [PDF]

, 2005
The innovations in computer and communications technologies combined with on-going needs to deliver educational programs to students regardless of their physical locations, have lead to the innovation of distance education programs and technologies.
Kukulska-Hulme, Agnes
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Romantic Attachment and Cognitive-Emotional Regulation in Psychological Maladjustment

Clínica y Salud. Investigación Empírica en Psicología
Romantic Attachment and Psychological Maladjustment: The study reveals that romantic attachment is a significant predictor of psychological maladjustment and depression.
Alicia Mena, Begoña Delgado, Miguel A. Carrasco, Francisco P. Holgado-Tello   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Teaching a distance higher education curriculum behind bars: challenges and opportunities [PDF]

, 2010
The provision of education that is both effective and relevant to the needs of students within prison is challenging on a number of levels. The uniqueness of prison culture with a regime characterised by a focus on security measures such as lock-downs ...
Watts, Jacqueline H.
core   +1 more source

The use of WCAG and automatic tools by computer science students: a case study evaluating MOOC accessibility [PDF]

Journal of Universal Computer Science
Web Content Accessibility Guidelines (WCAG) have been the de facto standard for Web accessibility evaluation for more than two decades and therefore have been introduced into legislation and university curriculum in Computer Science.
Francisco Iniesto, Covadonga Rodrigo
doaj   +3 more sources

Prediction of Physical and Mechanical Properties for Metallic Materials Selection Using Big Data and Artificial Neural Networks

IEEE Access, 2020
In this work, a computer-aided tool is developed to predict relevant physical and mechanical properties that are involved in the selection tasks of metallic materials.
D. Merayo, A. Rodriguez-Prieto, A. M. Camacho   +2 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Scale-Up Considerations of the Sundial Rotating Fresnel Solar Collector

SolarPACES Conference Proceedings
In the frame of the ASTEP project two prototypes of the Sundial collector, together with a Phase Change Material Thermal Energy Storage, will be tested integrated with the industrial processes of two sites.
Mercedes Ibarra, Rubén Barbero, Magdalena Barnetche, Rubén Abbas, Antonio Rovira   +4 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source