Results 111 to 120 of about 5,019,889 (353)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Setback distance impacts on transport and antibiotic resistance phenotypes of fecal indicators
Agrosystems, Geosciences & Environment, 2020 Although the land application of livestock manure has numerous agronomic benefits, runoff from manured fields can degrade water quality. Setbacks instruct a minimum distance be maintained between manure application and surface waters.
Morgan A. Meyers +5 more
doaj +1 more source
Distance‐based weighting methods for composite indicators, with applications related to energy sustainability [PDF]
, 2023 Roxani Karagiannis, Giannis Karagiannis
openalex +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Period–Luminosity–Metallicity–Color Relations of Late-type Contact Binaries in the Big Data Era
The Astrophysical JournalBinary stars ubiquitous throughout the Universe are important. Contact binaries (CBs) possessing period–luminosity (PL) relations could be adopted as distance tracers. The PL relations of CBs are influenced by metallicity abundance and color index, which
Lian-Yun Song, Zhi-Jia Tian
doaj +1 more source
Access to Food and Physical Activity Environment Resources in Rural Communities: Impact of Using Driving Time Versus Physical Distance Indicators. [PDF]
J Transp Health, 2022 Dixon BN +5 more
europepmc +1 more source
Measuring the Hubble Constant with the Hubble Space Telescope
, 2009 Ten years ago our team completed the Hubble Space Telescope Key Project on the extragalactic distance scale. Cepheids were detected in some 25 galaxies and used to calibrate four secondary distance indicators that reach out into the expansion field ...
J. R. Mould +6 more
core +1 more source
Supernovae as Distance Indicators
, 2020 A brief review of the uncertainties affecting type Ia supernova measurements. An expose for future use of type II supernovae is given as well.
openaire +1 more source