Results 111 to 120 of about 1,047,569 (316)

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

A physical distance indicator for spiral galaxies

, 1995
Plain TeX Version 3.0, 4 pages, to appear in `Astrophysical Letters and Communications' - proceedings of the international workshop on observational cosmology: `From Galaxies to Galaxy Systems', Sesto, July ...
Hendry, M. A., Rauzy, Stéphane, Salucci, P., Persic, M.   +3 more
openaire   +4 more sources

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

On the Pareto Compliance of the Averaged Hausdorff Distance as a Performance Indicator

Universitas Scientiarum, 2018
The averaged Hausdorff distance ∆p is an inframetric, recently introduced in evolutionary multiobjective optimization (EMO) as a tool to measure the optimality of finite size approximations to the Pareto front associated to a multiobjective ...
Andrés Vargas
doaj   +1 more source

MARKER-DEPENDENT RECOMBINATION IN T4 BACTERIOPHAGE. II. THE EVALUATION OF MISMATCH REPAIRABILITIES IN CROSSES WITHIN INDICATOR DISTANCES [PDF]

, 1982
Victor P. Shcherbakov, L A Plugina, Elena Kudryashova, O. I. Efremova, Svetlana Sizova, Oleg G Toompuu   +5 more
openalex   +1 more source

Market Indicators, Bank Fragility, and Indirect Market Discipline [PDF]

We examine whether two commonly used indicators of bank fragility, the subordinated debt spread and KMV’s distance to default, yield signals in line with supervisors’ interests.
Giuseppe Vulpes, Reint Gropp, Vesala Jukka   +2 more
core  

The Hubble Constant determined through an inverse distance ladder including quasar time delays and Type Ia supernovae

, 2019
Context. The precise determination of the present-day expansion rate of the Universe, expressed through the Hubble constant $H_0$, is one of the most pressing challenges in modern cosmology.
Birrer, S., Bonvin, V., Courbin, F., Jee, I., Komatsu, E., Rusu, C. E., Shajib, A. J., Suyu, S. H., Taubenberger, S., Wong, K. C.   +9 more
core   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Simulations of the Brightest Stars in Galaxies as Distance Indicators [PDF]

, 1986
L. Greggio
openalex   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source