Results 71 to 80 of about 3,650,464 (284)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
DISTANCE: a framework for software measure construction. [PDF]
In this paper we present a framework for software measurement that is specifically suited to satisfy the measurement needs of empirical software engineering research.
Dedene, Guido, Poels, Geert
core
Geometrical entanglement of highly symmetric multipartite states and the Schmidt decomposition
, 2011 In a previous paper we examined a geometric measure of entanglement based on the minimum distance between the entangled target state of interest and the space of unnormalized product states.
Barnum H +17 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Bhattacharyya’s distance measure as a precursor of genetic distance measures
Journal of Biosciences, 2004 In Population Genetics, two populations are distinguished from each other on the basis of the differences in the distributions of the alleles at the locus or loci under consideration. These differences are measured by a “genetic distance” between the two populations (not to be confused with genetic distance between two loci, which is based on ...
Aparna, Chattopadhyay +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
IEEE AccessThe significance of t-intuitionistic fuzzy TOPSIS lies in its ability to address challenges related to uncertainty and ambiguity within the decision-making process.
Dilshad Alghazzawi +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A Theoretical Development on Fuzzy Distance Measure
Journal of Mathematical Extension, 2015 Fuzzy distance measure is one of the most useful tools in applications. Many distance methods have been proposed so far. However, there is no method that can always give a satisfactory solution to every situation.
M. Alibeigi∗ +2 more
doaj