Results 61 to 70 of about 26,080 (290)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

A $(3+\varepsilon)$-Approximate Correlation Clustering Algorithm in Dynamic Streams [PDF]

TheoretiCS
Grouping together similar elements in datasets is a common task in data mining and machine learning. In this paper, we study streaming algorithms for correlation clustering, where each pair of elements is labeled either similar or dissimilar. The task is
Mélanie Cambus, Fabian Kuhn, Etna Lindy, Shreyas Pai, Jara Uitto   +4 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

State of the Art in Parallel Computing with R [PDF]

R is a mature open-source programming language for statistical computing and graphics. Many areas of statistical research are experiencing rapid growth in the size of data sets. Methodological advances drive increased use of simulations.
Hao Yu, Martin Morgan, Markus Schmidberger, Ulrich Mansmann, Luke Tierney, Dirk Eddelbuettel   +5 more
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Overview of Parallelism (SC '08 Education Program's Workshop on Parallel & Cluster Computing)

, 2008
Dr. Henry Neeman, Director OU Supercomputing Center for Education & Research University of Oklahoma SC08 Education Program’s Workshop on Parallel & Cluster computing August 10-16 2008OUTLINE: ----Parallelism ----The Jigsaw Puzzle Analogy for ...
Neeman, Henry
core  

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Training Large Models on Heterogeneous and Geo-Distributed Resource with Constricted Networks

Big Data Mining and Analytics
As the computational demands driven by large model technologies continue to grow rapidly, leveraging GPU hardware to expedite parallel training processes has emerged as a commonly-used strategy.
Zan Zong, Minkun Guo, Mingshu Zhai, Yinan Tang, Jianjiang Li, Jidong Zhai   +5 more
doaj   +1 more source

Comparison of numerical solution strategies for gravity field recovery from GOCE SGG observations implemented on a parallel platform [PDF]

Advances in Geosciences, 2003
The recovery of a full set of gravity field parameters from satellite gravity gradiometry (SGG) is a huge numerical and computational task. In practice, parallel computing has to be applied to estimate the more than 90 000 harmonic coefficients ...
R. Pail, G. Plank
doaj