Results 71 to 80 of about 2,116,890 (336)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Coordinating concurrent access in a distributed database architecture [PDF]
, 1978 Mishell J. Stucki +3 more
openalex +3 more sources
Scalable Database Access Technologies for ATLAS Distributed Computing
, 2009 ATLAS event data processing requires access to non-event data (detector conditions, calibrations, etc.) stored in relational databases. The database-resident data are crucial for the event data reconstruction processing steps and often required for user ...
Vaniachine, A.
core
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Retracted: Evaluation Method of Human Resource Management Efficiency of Chain Retail Enterprises Based on Distributed Database. [PDF]
Comput Math Methods Med, 2023 Methods In Medicine CAM.
europepmc +1 more source
Distributed Access View Integrated Database (DAVID) system [PDF]
The Distributed Access View Integrated Database (DAVID) System, which was adopted by the Astrophysics Division for their Astrophysics Data System, is a solution to the system heterogeneity problem. The heterogeneous components of the Astrophysics problem
Jacobs, Barry E.
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Using the IMEDS distributed database for epidemiological studies in type 2 diabetes mellitus. [PDF]
BMJ Open Diabetes Res Care, 2022 Huang TY +15 more
europepmc +1 more source
Resident database interfaces to the DAVID system, a heterogeneous distributed database management system [PDF]
A methodology for building interfaces of resident database management systems to a heterogeneous distributed database management system under development at NASA, the DAVID system, was developed.
Moroh, Marsha
core +1 more source