Results 71 to 80 of about 2,106,567 (294)

Scalable Database Access Technologies for ATLAS Distributed Computing

open access: yes, 2009
ATLAS event data processing requires access to non-event data (detector conditions, calibrations, etc.) stored in relational databases. The database-resident data are crucial for the event data reconstruction processing steps and often required for user ...
Vaniachine, A.
core  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Component Approach to Software Development for Distributed Multi-Database System [PDF]

open access: yes
The paper deals with a component based approach for software development in a distributed environment for the database retrieval operations. A Core Component for a distributed multi-database system has been proposed.
Muthaiyan MADIAJAGAN   +2 more
core  

Ownership principles for distributed database design [PDF]

open access: yes, 1992
Includes bibliographical references.Marshall Van Alstyne, Erik Brynjolfsson, Stuart E ...

core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Distributed Access View Integrated Database (DAVID) system [PDF]

open access: yes
The Distributed Access View Integrated Database (DAVID) System, which was adopted by the Astrophysics Division for their Astrophysics Data System, is a solution to the system heterogeneity problem. The heterogeneous components of the Astrophysics problem
Jacobs, Barry E.
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

A note on the performance analysis of static locking in distributed database systems [PDF]

open access: yes
Even though transaction deadlocks can severely affect the performance of distributed database systems, many current evaluation techniques ignore this aspect. Shyu and Li proposed an evaluation method which takes deadlocks into consideration.
Kuang, Yinghong, Mukkamala, Ravi
core   +1 more source

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