Results 61 to 70 of about 2,018,156 (259)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Consensus-based economic dispatch for DC microgrids incorporating realistic cyber delays
Alexandria Engineering JournalThis paper introduces a distributed control approach for optimizing the operation of islanded DC microgrids (µGs), accounting for cyber delays and network failures.
Mohamed Zaery +3 more
doaj +1 more source
Nonlinear Analysis, 2018 In this typescript, we concerned the problem of delay-dependent approach of impulsive genetic regulatory networks besides the distributed delays, parameter uncertainties and time-varying delays.
Selvakumar Pandiselvi +5 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Journal of Inequalities and Applications, 2011 In this paper, a class of impulsive bidirectional associative memory (BAM) fuzzy cellular neural networks (FCNNs) with time delays in the leakage terms and distributed delays is formulated and investigated.
Zhang Xinhua, Li Kelin
doaj
IEEE Access, 2020 In this paper, the diffusion effect, distributed delays and stochastic disturbance are involved in constructing the model of neural networks. Then, the global exponential synchronization problem is investigated for a class of reaction diffusion neural ...
Lijuan Chen +4 more
doaj +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Multi-delay complexity collapse
Physical Review Research, 2020 Increasing the number of delays in nonlinear dynamical systems is generally assumed to lead to higher complexity, but “distributed delay” systems with an infinite number of delays to lesser complexity.
S. Kamyar Tavakoli, André Longtin
doaj +1 more source