Results 121 to 130 of about 1,424,659 (349)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Continuous time controller based on SMC and disturbance observer for piezoelectric actuators [PDF]

, 2007
– In this work, analog application for the Sliding Mode Control (SMC) to piezoelectric actuators (PEA) is presented. DSP application of the algorithm suffers from ADC and DAC conversions and mainly faces limitations in sampling time interval.
Sabanovic, Asif, Yannier, Selim, Şabanoviç, Asif   +2 more
core  

Yet Another Tutorial of Disturbance Observer: Robust Stabilization and Recovery of Nominal Performance

, 2016
This paper presents a tutorial-style review on the recent results about the disturbance observer (DOB) in view of robust stabilization and recovery of the nominal performance. The analysis is based on the case when the bandwidth of Q-filter is large, and
Back, Juhoon, Jo, Nam Hoon, Joo, Youngjun, Park, Gyunghoon, Shim, Hyungbo   +4 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Evaluation of error bound for a DT sliding mode control with disturbance observer [PDF]

, 2006
In this paper an estimate of the upper bound of control error for discrete-time implementation of a Sliding Mode Control (DTSMC) combined with disturbance observer is investigated. Having in mind application to PZT high bandwidth actuators and since high
Abidi, Khalid Seyed, Erdem, Emine Yegan, Sabanovic, Asif, Şabanoviç, Asif   +3 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Improved nonlinear sliding mode control based on load disturbance observer for permanent magnet synchronous motor servo system

Advances in Mechanical Engineering, 2016
This article presented an improved nonlinear sliding mode control based on disturbance observer for the permanent magnet synchronous motor servo system.
Rongrong Qian, Minzhou Luo, Peng Sun
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Dynamic surface tracking controller design for a constrained hypersonic vehicle based on disturbance observer

International Journal of Advanced Robotic Systems, 2017
The tracking control problem of a flexible air-breathing hypersonic vehicle subjects to aerodynamic parameter uncertainty and input constraint is investigated by combining nonlinear disturbance observer and dynamic surface control.
Fang Wang, Qin Zou, Changchun Hua, Qun Zong   +3 more
doaj   +1 more source

Higher-Order State and Disturbance Observer With $O(T^{3})$ Errors for Linear Systems

IEEE Access, 2019
In this paper, a new observer, named as the higher-order observer, is proposed for simultaneously estimating the system state and disturbance. When the usual assumptions on the disturbance are satisfied, the magnitudes of the state and disturbance ...
Yue Fu, Dongwei Wang
doaj   +1 more source