Results 81 to 90 of about 33,178 (299)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Sliding mode control of the automobile electro-coating conveying mechanism with a nonlinear disturbance observer

open access: yesAdvances in Mechanical Engineering, 2018
The trajectory-tracking performance of the automobile electro-coating conveying mechanism is severely interrupted by highly nonlinear crossing couplings, unmodeled dynamics, parameter variation, friction, and unknown external disturbance. In this article,
Wei Yuan, Guoqin Gao
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Disturbance observer control method in SGMSCMG

open access: yesProceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, 2014
To restrain disturbances produced by parameter variations and external disturbances in axial magnetic bearing in the application of single-gimbal magnetically suspended control moment gyro (SGMSCMG), a disturbance observer control method is proposed, which integrated [Formula: see text] controller and disturbance observer.
Jin‐ji Sun, Cong Peng
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Disturbance observer-based robust tracking control for hypersonic vehicles with T-S disturbance modeling

open access: yesInternational Journal of Advanced Robotic Systems, 2016
This article concerns a disturbance observer-based L 1 robust anti-disturbance tracking algorithm for the longitudinal models of hypersonic flight vehicles with different kinds of unknown disturbances.
Yang Yi   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Research on anti-disturbance performance for servo system with a high dynamic performance velocity acquisition method

open access: yesJournal of Algorithms & Computational Technology, 2018
In order to achieve the requirements of high anti-disturbance and robustness performance for servo system, the acceleration control with disturbance observer is adopted in this paper, where the disturbance observer is used to estimate and compensate the ...
Ji Hua, Wang Shuang
doaj   +1 more source

Extended-State-Observer-Based Chattering Free Sliding Mode Control for Nonlinear Systems With Mismatched Disturbance

open access: yesIEEE Access, 2018
This paper presents a novel chattering free sliding mode control method for a class of nonlinear systems in the presence of matched disturbance and mismatched disturbance based on an extended state observer.
Sheng-Li Shi   +2 more
doaj   +1 more source

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