Results 71 to 80 of about 25,375 (264)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Reciprocal Neural State–Disturbance Observer for Model-Free Trajectory Tracking of Robotic Manipulators

Mathematics
High-precision trajectory tracking of robotic manipulators is fundamentally challenged by strong nonlinear dynamics, unmodeled uncertainties, and external disturbances.
Binluan Wang, Yuchen Peng, Hongzhe Jin, Jie Zhao   +3 more
doaj   +1 more source

Observation of a Class of Disturbance in Time Series Expansion for Fractional Order Systems

Abstract and Applied Analysis, 2014
This paper is concerned with the problem of designing disturbance observer for fractional order systems, of which the disturbance is in time series expansion. The stability of a special observer with the selected nonlinear weighted function and transient
Yiheng Wei, Hamid Reza Karimi, Jinwen Pan, Qing Gao, Yong Wang   +4 more
doaj   +1 more source

Comparative of disturbance suppression effect of Robust Steering control law by differential estimation methods

Nihon Kikai Gakkai ronbunshu, 2020
Recently, in the steering control system based on the steer by wire and the automatic operation, it is possible to flexibly change the relationship between steering input and vehicle response characteristics.
Toshio OHTA, Sundong YANG, Kenji TAKAHATA, Jianming YANG   +3 more
doaj   +1 more source

Disturbance observer control method in SGMSCMG

Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, 2014
To restrain disturbances produced by parameter variations and external disturbances in axial magnetic bearing in the application of single-gimbal magnetically suspended control moment gyro (SGMSCMG), a disturbance observer control method is proposed, which integrated [Formula: see text] controller and disturbance observer.
Jin‐ji Sun, Cong Peng
openaire   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Sliding mode control of the automobile electro-coating conveying mechanism with a nonlinear disturbance observer

Advances in Mechanical Engineering, 2018
The trajectory-tracking performance of the automobile electro-coating conveying mechanism is severely interrupted by highly nonlinear crossing couplings, unmodeled dynamics, parameter variation, friction, and unknown external disturbance. In this article,
Wei Yuan, Guoqin Gao
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source