Results 101 to 110 of about 281,561 (238)

Thiol-Disulfide Balance in Fibromyalgia: A Case-Control Study

Galician Medical Journal
Aim. We aimed to examine the thiol-disulfide (SS) balance, a recognized marker of oxidative stress, in fibromyalgia syndrome (FMS). Methods. The study comprised 98 female participants (61 newly diagnosed patients and 37 patients under treatment) with ...
Esra Sahingoz Bakirci, Baris Nacir, Murat Alisik, Hakan Genc, Elmas Ogus, Gulseren Demir Karakilic, Ferda Buyuk, Ozcan Erel   +7 more
doaj   +1 more source

Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi, Matthew B. Baker, Dominik Schauenburg   +2 more
wiley   +1 more source

Characterising the expression and interactions of the Endoplasmic Reticulum Oxidoreductase Erol β [PDF]

, 2006
Proteins destined for the secretory pathway and endoplasmic reticulum (ER) resident proteins are targeted to the ER through an N-terminal signal sequence. Proteins then follow a post-translational maturation process to fold into functional proteins.
Gunasekara, Sanjika Dias
core  

Can Elastomers Combine Stiffness, Toughness and Fatigue Resistance?

Advanced Materials, EarlyView.
This review studies how the molecular and macroscopic architecture of elastomers influence their mechanical properties including: stiffness, stretchability, toughness, fatigue resistance, and damping behavior. By linking the structure to performance, it proposes design principles for advanced elastomeric systems that combine mechanical properties ...
Eva Baur, Esther Amstad
wiley   +1 more source

Disulfide-Directed Multicyclic Peptide Libraries for the Discovery of Peptide Ligands and Drugs

Multicyclic peptides with stable 3D structures are a kind of novel and promising peptide formats for drug design and discovery as they have the potential to combine the best characteristics of small molecules and proteins.
Hongtan Liu (12244451), Shuling Xiao (14404408), Yibing Zhao (1404550), Jinjing Li (659151), Shihui Fan (6760937), Shilong Zhang (8576355), Yapei Wu (4168285), Jie Zhuang (479153), Chuanliu Wu (1404553), Chuilian Kong (14404411), Shuaimin Lu (9366885)   +10 more
core   +1 more source

The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes [PDF]

, 2010
Human islet amyloid polypeptide (hIAPP) forms amyloid fibrils in pancreatic islets of patients with type 2 diabetes mellitus. It has been suggested that the N-terminal part, which contains a conserved intramolecular disulfide bond between residues 2 and ...
Medicinal Chemistry and Chemical Biology, Sub Medicinal Chemistry begr. 01-01-2014, Dep Farmaceutische wetenschappen, Khemtemourian, L.P., Engel, M.F.M., Hoppener, J.W.M., SYNTHESE, Sub Biochemistry of Membranes begr1-6-12, Liskamp, R.M.J., Kruijtzer, J.A.W., Killian, J.A., Sub Medicinal Chemistry & Chemical biol.   +11 more
core  

Lactate Dehydrogenase-B Oxidation and Inhibition by Singlet Oxygen and Hypochlorous Acid

Oxygen
Alterations in cellular energy metabolism are a hallmark of cancer and lactate dehydrogenase (LDH) enzymes are overexpressed in many cancers regardless of sufficient oxygen and functional mitochondria. Further, L-lactate plays signaling roles in multiple
Lisa M. Landino, Emily E. Lessard
doaj   +1 more source

Barrier‐Assisted Plasma Doping for Spatially Selective Resistance Engineering in MoS2 Transistors

Advanced Materials, EarlyView.
Barrier‐assisted NH3 plasma doping enables damage‐free, spatially selective carrier modulation in monolayer MoS2 transistors. An ultrathin pV3D3/Al2O3 protective‐dielectric stack acts as a chemical filter that allows NHx radicals to reach the MoS2 surface while blocking plasma damage. This process achieves a high electron concentration of 4.3 × 1013 cm−
Inseong Lee, Joonho Park, Seungsun Yoo, Seunghyun Yu, Mingu Kang, Seohak Park, Min Kyu Lee, Hyeongjin Lim, Dongyoung Kim, Kunwoo Roh, Sejin Kim, Kihyuk Kim, Wonbae Ahn, Kibum Kang, Yong‐Hoon Kim, Sung‐Yool Choi   +15 more
wiley   +1 more source

Occupational exposure to carbon-disulfide [PDF]

"The recommended standard is given limiting employee exposure to less than 3 milligrams per cubic meter of air (1ppm) as a time weighted average concentration for up to a 10 hour work shift in a 40 hour workweek or less than 30 milligrams per cubic meter

core   +1 more source

Discovery of a Novel Insecticidal Peptide with a Cystine-Stabilized α-Helix/α-Helix Motif from the Venom of Scorpion Liocheles australasiae

Molecules
Scorpion venom contains various bioactive peptides, many of which exhibit insecticidal activity. The majority of these peptides have a cystine-stabilized α-helix/β-sheet (CSαβ) motif. In addition to these peptides, scorpion venom also contains those with
Masahiro Miyashita, Naoya Mitani, Fuki Iwamoto, Mitsuki Hirota, Yoshiaki Nakagawa   +4 more
doaj   +1 more source