Results 181 to 190 of about 96,012 (310)

Development of Endogenous Protein Probes for Characterizing Surface Proteins and Cellular Interactors of Extracellular Vesicles

Advanced Science, EarlyView.
The proximity labeling enzyme APEX2 is displayed on extracellular vesicle (EV) surfaces via genetic fusion with EV‐sorting scaffolds, enabling in situ biotinylation of native surface proteins, adsorbed corona components, and interacting cellular proteins.
Wenyi Zheng, Metoboroghene Mowoe, Wenqing Hou, Daniel W. Hagey, Koshi Imami, Samir EL Andaloussi   +5 more
wiley   +1 more source

A-to-I mRNA editing in bacteria can affect protein sequence, disulfide bond formation, and function. [PDF]

Nucleic Acids Res
Didi L, Fargeon O, Aspit L, Elias E, Braverman D, Melamed D, Keidar-Friedman D, Sorek N, Raz O, Tamir SO, Zarivach R, Sal-Man N, Dahan O, Pilpel Y, Bar Yaacov D.   +14 more
europepmc   +1 more source

Modulating Purothionin Accumulation and Signal Peptide Cleavage Fine‐Tunes Wheat Flour Gluten Properties to Improve Cookie‐Making Quality

Advanced Science, EarlyView.
Dual genetic strategies for improving wheat processing quality by regulating purothionin accumulation to modulate gluten quantity and quality. The first strategy involves targeting signal peptide (SP) cleavage sites (e.g., through mutation) to indirectly reduce gluten content, thereby disrupting gluten network formation.
Yijie Liu, Siyuan Chang, Zhaoheng Zhang, Tianqi Kang, Mingde Liu, Yuan Zong, Fei Ni, Yinguang Bao, Ruijie Zhang, Xiaobang Zhang, Jinkun Du, Mingming Xin, Zhaorong Hu, Jie Liu, Zhongfu Ni, Qixin Sun, Yingyin Yao   +16 more
wiley   +1 more source

Development of Water-Soluble 3-Nitro-2-Pyridinesulfenate for Disulfide Bond Formation of Peptide Under Aqueous Conditions. [PDF]

Chemistry
Taguchi A, Sakata M, Yamamoto R, Shida H, Kuraishi S, Konno S, Takayama K, Taniguchi A, Hayashi Y.   +8 more
europepmc   +1 more source

A Novel Synthetic Approach of Tryptophan-Containing Cystine Peptides by Regioselective Disulfide Bond-Forming Reaction Using the Silyl Chloride-Sulfoxide System

, 2000
Yasushi Fujiwara
openalex   +2 more sources

Bacteriophage‐Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery

Advanced Science, EarlyView.
We designed a synthetic DNA origami needle‐like structure inspired by bacteriophages for targeted drug delivery. Functionalized with trastuzumab antibodies, cholesterol, and dyes, it selectively targets SKBR3 cancer cells. A glutathione‐triggered dye payload enables controlled release, and delivery is verified using confocal microscopy and live cell ...
Anirban Samanta, Mette Galsgaard Malle, Emily Tsang, Marjan Omer, Mads K. Skaanning, Sarah Youssef, Jørgen Kjems, Kurt V. Gothelf   +7 more
wiley   +1 more source

Disulfide bond-related gene signature development for bladder cancer prognosis prediction and immune microenvironment characterization. [PDF]

Sci Rep
Huang H, Shao H, Wang Y, Ge L.
europepmc   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Auranofin induces disulfide bond-mimicking S-Au adducts in protein thiol pairs. [PDF]

J Biol Chem
Quadros Barsé L, Düchting P, Lupilov N, Bandow JE, Krämer U, Leichert LI.   +5 more
europepmc   +1 more source

UV-photochemistry of the biologically relevant thiol group and the disulfide bond: Evolution of early photoproducts from picosecond X-ray absorption spectroscopy at the sulfur K-Edge [PDF]

, 2019
Miguel Ochmann, Abid Hussain, Inga von Ahnen, Amy A. Cordones, Kiryong Hong, Jae Hyuk Lee, Rory Ma, Katrin Adamczyk, Tae Kyu Kim, R. W. Schoenlein, Oriol Vendrell, Nils Huse   +11 more
openalex   +1 more source