Results 21 to 30 of about 96,012 (310)
Measurement of Redox States of the β3 Integrin Disulfide Bonds by Mass Spectrometry
Bio-Protocol, 2019 Functional disulfide bonds mediate a change in protein function in which they reside when cleaved or formed. To elucidate how a functional disulfide bond controls protein activity, it is critical that the redox state of the bond in the population of ...
Joyce Chiu
doaj +1 more source
Engineering a disulfide bond in the lid hinge region of Rhizopus chinensis lipase: increased thermostability and altered acyl chain length specificity. [PDF]
PLoS ONE, 2012 The key to enzyme function is the maintenance of an appropriate balance between molecular stability and structural flexibility. The lid domain which is very important for "interfacial activation" is the most flexible part in the lipase structure. In this
Xiao-Wei Yu +3 more
doaj +1 more source
TREATMENT OF DISULFIDE BONDS IN COARSE-GRAINED UNRES FORCE FIELD
TASK Quarterly, 2016 Disulfide bonds, despite the advances of the computational methods, are underrepresented in theoretical chemistry and the role of disulfide bonds is often diminished in bioinformatical studies.
PAWEŁ KRUPA
doaj +1 more source
IUCrJ, 2020 Radiation-induced damage to protein crystals during X-ray diffraction data collection is a major impediment to obtaining accurate structural information on macromolecules.
Rajasri Bhattacharyya +4 more
doaj +1 more source
Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor [PDF]
Open Biology, 2012 Certain disulfide bonds present in leucocyte membrane proteins are labile and can be reduced in inflammation. This can cause structural changes that result in downstream functional effects, for example, in integrin activation.
Clive Metcalfe +2 more
doaj +1 more source
PLoS ONE, 2015 MIS416 is an intact minimal cell wall skeleton derived from Proprionibacterium acnes that is phagocytosed by antigen presenting cells, including dendritic cells (DCs).
Francesco Mainini +4 more
doaj +1 more source
Disulfide bond formation and ToxR activity in Vibrio cholerae. [PDF]
PLoS ONE, 2012 Virulence factor production in Vibrio cholerae is complex, with ToxRS being an important part of the regulatory cascade. Additionally, ToxR is the transcriptional regulator for the genes encoding the major outer membrane porins OmpU and OmpT.
Vera H I Fengler +7 more
doaj +1 more source
iScience, 2021 Summary: The mammalian endoplasmic reticulum (ER) harbors more than 20 members of the protein disulfide isomerase (PDI) family that act to maintain proteostasis.
Chihiro Hirayama +7 more
doaj +1 more source
Synthesis of the Most Potent Isomer of μ-Conotoxin KIIIA Using Different Strategies
Molecules, 2023 In the chemical synthesis of conotoxins with multiple disulfide bonds, the oxidative folding process can result in diverse disulfide bond connectivities, which presents a challenge for determining the natural disulfide bond connectivities and leads to ...
Xunxun Jian +5 more
doaj +1 more source
PLoS ONE, 2015 Maternal nicotine exposure has been associated with many adverse fetal and placental outcomes. Although underlying mechanisms remain elusive, recent studies have identified that augmented endoplasmic reticulum (ER) stress is linked to placental ...
Michael K Wong +3 more
doaj +1 more source