European Journal of Pediatrics, 2023 Diuretics are frequently prescribed drugs and help managing several pathological conditions, including acute and chronic kidney disease, nephrotic syndrome, congestive heart failure, ascites, systemic and pulmonary hypertension. Diuretic classes include among others osmotic diuretics and carboanhydrase inhibitors, loop diuretics, thiazides, and ...
Sebastiano A G, Lava +5 more
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Association of diuretics with falls and wrist fractures: a Mendelian randomization study [PDF]
Frontiers in Public HealthBackgroundThe association between diuretics and falls in older adult has been reported in previous studies, but discrepancy remains between the different types of diuretics.
Fei Liu +5 more
doaj +2 more sources
Molecular mechanisms of thiazide-like diuretics-mediated inhibition of the human Na-Cl cotransporter
Nature CommunicationsThiazide-type and thiazide-like diuretics are structurally distinct first-line antihypertensive drugs that target the sodium-chloride cotransporter (NCC) in the kidney.
Chien-Ling Lee +2 more
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European Consensus on use of diuretics in chronic heart failure 2019 [PDF]
Медицинский совет, 2020 The article presents the consensus materials of the European Society of Cardiology on the use of diuretics in chronic heart failure (CHF). Diuretics represent an important class of drugs for the treatment of heart failure from the perspective of evidence
M. V. Leonova
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UMOD Genotype and Clinical Outcomes in Heart Failure Patients Treated with Loop Diuretics: A UK Biobank Pharmacogenetic Cohort Study. [PDF]
Clin Pharmacol TherUromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Kreutz R +5 more
europepmc +2 more sources
Diuretics in chronic kidney disease [PDF]
, 2020 The issues of diuretic therapy in patients with chronic kidney disease, pharmacokinetics of diuretics, the problem of diuretic resistance, the tactics of using thiazides and loop diuretics in patients with various stages of chronic kidney disease ...
A. I. Dyadyk +4 more
core +1 more source
Comparison of single and combination diuretics on glucose tolerance (PATHWAY-3):protocol for a randomised double-blind trial in patients with essential hypertension [PDF]
, 2015 INTRODUCTION: Thiazide diuretics are associated with increased risk of diabetes mellitus. This risk may arise from K(+)-depletion. We hypothesised that a K(+)-sparing diuretic will improve glucose tolerance, and that combination of low-dose thiazide with
Salsbury, J +21 more
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New Strategies for Volume Control in Patients with Diabetes Mellitus, a Narrative Review
Pharmaceutics, 2022 Sodium is reabsorbed all along the renal tubules. The positive impacts of sodium-glucose cotransporter-2 inhibitors (SGLT2i), angiotensin receptor neprilysin inhibitor (ARNI) and mineralocorticoid receptor antagonists (MRA) on hard renal and/or cardiac ...
Alexandre O. Gérard +7 more
doaj +1 more source
Diuretics — a review of the current knowledge
, 2023 Diuretics are drugs that increase diuresis and natriuresis. Diuretics reduce sodium reabsorption in the proximal tubule (SGLT2 inhibitors, carbonic anhydrase inhibitors), the loop of Henle (loop diuretics), the distal tubule (thiazide and thiazide-like ...
Więcek, Andrzej; Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia in Katowice +2 more
core +1 more source
Magnesium: The Forgotten Electrolyte—A Review on Hypomagnesemia
Medical Sciences, 2019 Magnesium is the fourth most abundant cation in the body and the second most abundant intracellular cation. It plays an important role in different organ systems at the cellular and enzymatic levels.
Faheemuddin Ahmed, Abdul Mohammed
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