Results 1 to 10 of about 454 (115)

In Silico Drug Design of Benzothiadiazine Derivatives Interacting with Phospholipid Cell Membranes [PDF]

Membranes, 2022
The use of drugs derived from benzothiadiazine, a bicyclic heterocyclic benzene derivative, has become a widespread treatment for diseases such as hypertension, low blood sugar or the human immunodeficiency virus, among others.
Zheyao Hu, Jordi Marti
doaj   +2 more sources

BTDAzo: A Photoswitchable TRPC5 Channel Activator. [PDF]

Angew Chem Int Ed Engl, 2022
The TRPs (Transient Receptor Potentials) are important sensory ion channels with roles in perception including of heat, cold, and electrophiles, as well as in signaling and mineralostasis. Here the first photopharmaceutical TRPC5 ligand, BTDAzo, is developed, which achieves outstanding photoswitchability of TRPC5 currents in physiological models ...
Müller M, Niemeyer K, Urban N, Ojha NK, Zufall F, Leinders-Zufall T, Schaefer M, Thorn-Seshold O.   +7 more
europepmc   +3 more sources

Synthesis and In Vitro Antileishmanial Efficacy of Novel Ethylene Glycol Analogues of Benzothiadiazine-1,1-dioxide. [PDF]

Chem Biodivers
Abstract Leishmaniasis is a vector‐borne, parasitic disease affecting millions of people and animals worldwide. Current therapeutic options have proven to be ineffective in both treating the disease and preventing its spread. As a result, new drugs must be developed to effectively combat this disease.
Henning N, Kannigadu C, Aucamp J, Janse van Rensburg HD, van der Kooy F, van der Kooy F, N'Da DD.   +6 more
europepmc   +2 more sources

A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A. [PDF]

PLoS ONE, 2011
RNA synthesis by the genotype 1b hepatitis C virus (HCV) polymerase (NS5B) transiently expressed in Human embryonic kidney 293T cells or liver hepatocytes was found to robustly stimulate RIG-I-dependent luciferase production from the interferon β ...
C T Ranjith-Kumar, Yahong Wen, Nielson Baxter, Kanchan Bhardwaj, C Cheng Kao   +4 more
doaj   +2 more sources

Cyclization Reaction of α‑Hydroxyketones with Anthranilamides or 2‑Aminobenzenesulfonamides for the Synthesis of Quinazolinones and Benzothiadiazines [PDF]

ACS Omega
Ze-Xin Niu, Qing-Yang Zhang, Xin-Yi Zhao, Hui-Peng Sun, Zi-Wen Wu, Lei-Lei Chao, Wen-Yun Gao, Heng Li   +7 more
doaj   +2 more sources

Synthesis and molecular docking studies of novel tricyclic and angular tetracyclic benzothiadiazines via sp3‐C‐H activation as potential colon cancer inhibitors

Journal of Heterocyclic Chemistry, Volume 60, Issue 10, Page 1738-1759, October 2023., 2023
Substituted tricyclic and tetracyclic benzothiadiazines were synthesized in this paper, were synthesized via metal‐free intramolecular N‐iodosuccinimide (NIS)‐mediated radical oxidative sp3‐C‐H activation aminative cyclization. Docking studies of the tricyclic and angular tetracyclic 1,2,4‐benzothiadizine dioxides 26–34 and intermediates were carried ...
Sherif O. Kolade, Oluwafemi S. Aina, Allen T. Gordon, Eric C. Hosten, Idris A. Olasupo, Adeniyi S. Ogunlaja, Olayinka T. Asekun, Oluwole B. Familoni   +7 more
wiley   +1 more source

A Copper‐Catalyzed Interrupted Domino Reaction for the Synthesis of Fused Triazolyl Benzothiadiazine‐1‐oxides

Chemistry – A European Journal, Volume 29, Issue 13, March 1, 2023., 2023
A copper(I)‐catalyzed interrupted domino reaction of 2‐azido sulfoximines with 1‐iodoalkynes affords fused triazolyl‐containing benzothiadiazine‐1‐oxides in good to excellent yields. The substrate scope is broad and the functional group tolerance high.
Renè Hommelsheim, Sandra Bausch, Arjuna Selvakumar, Mostafa M. Amer, Khai‐Nghi Truong , Kari Rissanen, Carsten Bolm   +6 more
wiley   +1 more source

Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations

Journal of Analytical Methods in Chemistry, Volume 2023, Issue 1, 2023., 2023
Simple, accurate, precise, and cost‐effective chemometric techniques for the measurement of candesartan cilexetil and hydrochlorothiazide in synthetic mixtures were improved and validated. H‐point standard addition, Q‐absorption ratio, and correction absorbance spectrophotometric techniques were utilized for the simultaneous determination of both ...
Diyar Salahuddin Ali, Ricardo Jorgensen Cassella   +1 more
wiley   +1 more source

A case of insulinoma effectively treated with low‐dose diazoxide

Clinical Case Reports, Volume 8, Issue 10, Page 1884-1889, October 2020., 2020
Diazoxide is a benzothiadiazine that can be effective in managing hypoglycemia in frail patients with surgical risk. We report here a case of insulinoma effectively treated with diazoxide, as our report will be helpful for similar cases. Abstract Diazoxide is a benzothiadiazine that can be effective in managing hypoglycemia in frail patients with ...
Atsushi Yasuda, Toshiro Seki, Natsumi Kitajima, Tanefumi Baba, Noriko Sasaki, Yoshie Kametani, Masami Seki, Kazuko Tanaka, Masayuki Oki   +8 more
wiley   +1 more source

Effects of benzothiadiazine drugs on carbohydrate metabolism [PDF]

Metabolism, 1965
Abstract The administration of chlorothiazide both to man and to rats results in hyperglycemia following a glucose load. Its administration to rats causes a decreased rate of glucose utilization by their adipose tissue in vitro. Chlorothiazide added directly to the incubating medium also decreases the rate of glucose utilization of rat adipose tissue.
Weller, John M., Borondy, Paul E.
openaire   +3 more sources