In Silico Drug Design of Benzothiadiazine Derivatives Interacting with Phospholipid Cell Membranes [PDF]
Membranes, 2022 The use of drugs derived from benzothiadiazine, a bicyclic heterocyclic benzene derivative, has become a widespread treatment for diseases such as hypertension, low blood sugar or the human immunodeficiency virus, among others.
Zheyao Hu, Jordi Marti
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A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A. [PDF]
PLoS ONE, 2011 RNA synthesis by the genotype 1b hepatitis C virus (HCV) polymerase (NS5B) transiently expressed in Human embryonic kidney 293T cells or liver hepatocytes was found to robustly stimulate RIG-I-dependent luciferase production from the interferon β ...
C T Ranjith-Kumar +4 more
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Cyclization Reaction of α‑Hydroxyketones with Anthranilamides or 2‑Aminobenzenesulfonamides for the Synthesis of Quinazolinones and Benzothiadiazines [PDF]
ACS OmegaZe-Xin Niu +7 more
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Effects of benzothiadiazine drugs on carbohydrate metabolism [PDF]
Metabolism, 1965 Abstract The administration of chlorothiazide both to man and to rats results in hyperglycemia following a glucose load. Its administration to rats causes a decreased rate of glucose utilization by their adipose tissue in vitro. Chlorothiazide added directly to the incubating medium also decreases the rate of glucose utilization of rat adipose tissue.
Weller, John M., Borondy, Paul E.
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Anti-HIV-1 Activity of Benzothiadiazine Dioxide
Antiviral Chemistry and Chemotherapy, 2001 Antiviral assays carried out on the potent benzothiadiazine dioxide (BTD) human cytomegalovirus (HCMV) inhibitors have led us to find marginal but selective anti-HIV-1 activity. Specific pharmacological studies, such as time of addition experiments and assays on specific viral strains with mutations on its reverse transcriptase, have indicated that ...
Martinez, A. +7 more
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Discovery of Halogenated Benzothiadiazine Derivatives with Anticancer Activity**
ChemMedChem, 2020 Abstract Mitochondrial respiratory complex II (CII), also known as succinate dehydrogenase, plays a critical role in mitochondrial metabolism. Known but low potency CII inhibitors are selectively cytotoxic to cancer cells including the benzothiadiazine‐based anti‐hypoglycemic diazoxide.
Bader I. Huwaimel +7 more
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Chlorinated benzothiadiazines inhibit angiogenesis through suppression of VEGFR2 phosphorylation. [PDF]
Bioorg Med Chem, 2022 Huwaimel BI +7 more
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A short, versatile route towards benzothiadiazinyl radicals. [PDF]
Chem Sci, 2021 Borys AM +4 more
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In silico identification of promising inhibitor against RNA-dependent RNA polymerase target of SARS-CoV-2. [PDF]
Mol Biol Res Commun, 2021 Singh P +4 more
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