Results 31 to 40 of about 763 (164)

Canonical Transient Receptor Potential (TRPC) Channels in Nociception and Pathological Pain

Neural Plasticity, Volume 2020, Issue 1, 2020., 2020
Chronic pathological pain is one of the most intractable clinical problems faced by clinicians and can be devastating for patients. Despite much progress we have made in understanding chronic pain in the last decades, its underlying mechanisms remain elusive.
Zhi-Chuan Sun, Sui-Bin Ma, Wen-Guang Chu, Dong Jia, Ceng Luo, Gernot Riedel   +5 more
wiley   +1 more source

Impact of process variables on the micromeritic and physicochemical properties of spray-dried microparticles, part II: physicochemical characterisation of spray-dried materials [PDF]

, 2012
YesObjectives  In this work we investigated the residual organic solvent content and physicochemical properties of spray-dried chlorothiazide sodium (CTZNa) and potassium (CTZK) salts.
Al-Obaidi, Anne Marie Healy, Burnett, Corrigan, Council of Europe, Dobry, Gil, Gilani, Hancock, Hancock, Harjunen, Holubová, Kim, Krzysztof J. Paluch, Lidia Tajber, Maria I. Amaro, Mollica, Mollica, Nolan, NíÓgáin, Owen I. Corrigan, Paluch, Paluch, Paluch, Quesenberry, Seidell, Tajber, Tajber, Ulvi   +28 more
core   +1 more source

APPLICATION OF THE MACHINE AND DEEP LEARNING METHODS FOR THE CLASSIFICATION OF CANNABINOID- AND CATHINONE-DERIVED COMPOUNDS [PDF]

, 2020
Objective: New psychoactive substances (NPS) have been rapidly developed to avoid legal entanglement. In 2013–2018, the number of cathinonederivedcompounds increased from 30 to 89.
ARYATI, WIDYA DWI, SUSANTO, GERRY MAY, WINARKO, MUHAMMAD SIDDIQ, YANUAR, ARRY   +3 more
core   +3 more sources

Transjugular Leadless Pacemaker Implantation in an Adolescent With Central Hypoventilation Syndrome: A Case Report

Pacing and Clinical Electrophysiology, Volume 49, Issue 5, Page 606-609, May 2026.
ABSTRACT Background Permanent pacing in pediatric patients is complicated by small body size, vascular access limitations, and the need for durable long‐term management. Leadless pacemakers offer an emerging alternative that minimizes infection and lead‐related complications, yet vascular access remains a key challenge in young patients.
Marzia Giaccardi, Gulio Porcedda, Zaccaria Ricci, Hendrik Bonnemeier, Benito Baldauf   +4 more
wiley   +1 more source

Thiazide‐Associated Hyponatremia: A Retrospective Cohort Study Comparing Hydrochlorothiazide Versus Indapamide Versus Chlorthalidone

The Journal of Clinical Hypertension, Volume 27, Issue 5, May 2025.
ABSTRACT Hyponatremia is a crucial complication of therapy with thiazide diuretics. This study compares the epidemiological and biochemical profiles and hospital course of patients using hydrochlorothiazide (HCTZ), indapamide (INDA), and chlorthalidone (CTD) admitted with thiazide‐associated hyponatremia (TAH).
Josef Klhůfek, Martin Vodička, Petr Ponížil, Ilja Ryšavý, Petr Fojtík, Vladimír Kojecký, Tomáš Šálek   +6 more
wiley   +1 more source

Managing Hypoglycaemia in Patients With Insulinoma—A Tertiary Centre Experience and Review of the Literature

Clinical Endocrinology, Volume 102, Issue 3, Page 344-354, March 2025.
ABSTRACT The management of hypoglycaemia is pivotal in the care of patients with insulinoma. Blood glucose monitoring and regulation needs careful attention pre‐ and peri‐operatively for patients undergoing surgical resection and as part of the long‐term management for patients with inoperable or metastatic disease.
Sophie Howarth, Tak‐Wai Ho, James Wimbury, Ruth Casey   +3 more
wiley   +1 more source

Potent, selective, and subunit‐dependent activation of TRPC5 channels by a xanthine derivative

British Journal of Pharmacology, Volume 176, Issue 20, Page 3924-3938, October 2019., 2019
Background and Purpose The TRPC1, TRPC4, and TRPC5 proteins form homotetrameric or heterotetrameric, calcium‐permeable cation channels that are involved in various disease states. Recent research has yielded specific and potent xanthine‐based TRPC1/4/5 inhibitors.
Aisling Minard, Claudia C. Bauer, Eulashini Chuntharpursat‐Bon, Isabelle B. Pickles, David J. Wright, Melanie J. Ludlow, Matthew P. Burnham, Stuart L. Warriner, David J. Beech, Katsuhiko Muraki, Robin S. Bon   +10 more
wiley   +1 more source

2-[7-Chloro-1,1-dioxo-2-(2,4,5-trifluoro­benz­yl)-3,4-dihydro-2H-1,2,4-benzothia­diazin-4-yl]acetic acid [PDF]

, 2012
In the mol­ecule of the title compound, C16H12ClF3N2O4S, the thia­diazine ring adopts a half-chair conformation. The dihedral angle between the benzene ring of the benzothia­diazine ring system and trifluoro­phenyl group is 15.02 (7)°.
Braghiroli, Buckheit, Changjin Zhu, Chen, Francotte, Longman, Phillips, Pirotte, Sheldrick, Yamada, Yanchun Yang, Yuhua Guo   +11 more
core   +3 more sources

Palladium-Catalyzed Domino Cycloisomerization/Double Condensation of Acetylenic Acids with Dinucleophiles [PDF]

, 2022
first_page settings Open AccessArticle Palladium-Catalyzed Domino Cycloisomerization/Double Condensation of Acetylenic Acids with Dinucleophiles by Nerea Conde , María Teresa Herrero , Garazi Urgoitia and Raul SanMartin * [ORCID] Department of ...
Conde García, Nerea, Herrero Corral, María Teresa, San Martin Faces, Raúl, Urgoitia Gabikaetxebarria, Garazi   +3 more
core   +1 more source

Pioneering Metal‐Free Late‐Stage C−H Functionalization Using Acridinium Salt Photocatalysis

Chemistry – A European Journal, Volume 30, Issue 67, December 2, 2024.
Organic dyes are powerful photocatalysts in organic transformations due to their availability, adaptable absorption, and diverse structures. Acridinium‐based organo‐photocatalysts, notable for visible light responsiveness, efficiently functionalize inert C−H bonds under mild conditions without transition metals.
Shyamal Kanti Bera, Andrea Porcheddu
wiley   +1 more source