Results 21 to 30 of about 600 (157)

A Novel Small Molecule Accelerates Early Persister Regrowth and Potentiates Antibiotic Killing via MdtL–DcrB

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
bymBDZ accelerates early regrowth of persister‐derived E. coli and potentiates antibiotic killing. Its activity requires the MdtL–DcrB axis and is associated with envelope‐linked transport changes that increase intracellular small‐molecule exposure during recovery, thereby enhancing clearance in early treatment windows. ABSTRACT Persister cells survive
Garin Park, Hyein Kim, Sooyeon Song
wiley   +1 more source

Transjugular Leadless Pacemaker Implantation in an Adolescent With Central Hypoventilation Syndrome: A Case Report

Pacing and Clinical Electrophysiology, Volume 49, Issue 5, Page 606-609, May 2026.
ABSTRACT Background Permanent pacing in pediatric patients is complicated by small body size, vascular access limitations, and the need for durable long‐term management. Leadless pacemakers offer an emerging alternative that minimizes infection and lead‐related complications, yet vascular access remains a key challenge in young patients.
Marzia Giaccardi, Gulio Porcedda, Zaccaria Ricci, Hendrik Bonnemeier, Benito Baldauf   +4 more
wiley   +1 more source

Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Biological Characterization of Unsymmetrical Dialkyl-Hydroxynaphthalenoyl-benzothiadiazines

, 2016
The hepatitis C virus (HCV) NS5B polymerase is essential for viral replication and has been a prime target for drug discovery research. Our efforts directed toward the discovery of HCV polymerase inhibitors resulted in the identification of unsymmetrical
Douglas K. Hutchinson (2371957), Todd D. Bosse (2384224), John F. Darbyshire (2384245), Dale J. Kempf (2332114), Rolf Wagner (29866), Lisa E. Hernandez (2371939), John K. Pratt (2384242), Daniel P. Larson (2384236), Clarence J. Maring (1833961), Sherie V. Masse (2371963), Michelle A. Long (2384230), William Kohlbrenner (2384239), Wen W. Jiang (2371945), Yi Gao (112914), David W. A. Beno (2110654), Jinrong Liu (733835), Gennadiy Koev (1833994), Warren M. Kati (1833985), A. Chris Krueger (1833955), Tim Middleton (2384221), Larry L. Klein (1828195), Yaya Liu (2371966), Debra A. Montgomery (2371951), Akhteruzzaman Molla (2332132), Patricia Stuart (2384233), Bradley D. Gates (2384227), Wenping He (1408009), Rodger F. Henry (1744156)   +27 more
core   +1 more source

Insulinoma in a dog (Canis lupus familiaris) with concurrent non‐cardiogenic pulmonary oedema

Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.
Abstract A 12‐year‐old, female, neutered beagle presented with hypoglycaemia, sudden‐onset non‐ambulatory tetraparesis and a single tonic‐clonic seizure. Computed tomography revealed a pancreatic nodule, consistent with an insulinoma, an enlarged hepatic lymph node and ground‐glass attenuation of the lung parenchyma, most consistent with non ...
Dylan O’ Toole, Julia Riggs, Tom Butler, Chantelle Franklin, Hannah Wong, Barbara Skelly   +5 more
wiley   +1 more source

Thiazide‐Associated Hyponatremia: A Retrospective Cohort Study Comparing Hydrochlorothiazide Versus Indapamide Versus Chlorthalidone

The Journal of Clinical Hypertension, Volume 27, Issue 5, May 2025.
ABSTRACT Hyponatremia is a crucial complication of therapy with thiazide diuretics. This study compares the epidemiological and biochemical profiles and hospital course of patients using hydrochlorothiazide (HCTZ), indapamide (INDA), and chlorthalidone (CTD) admitted with thiazide‐associated hyponatremia (TAH).
Josef Klhůfek, Martin Vodička, Petr Ponížil, Ilja Ryšavý, Petr Fojtík, Vladimír Kojecký, Tomáš Šálek   +6 more
wiley   +1 more source

Managing Hypoglycaemia in Patients With Insulinoma—A Tertiary Centre Experience and Review of the Literature

Clinical Endocrinology, Volume 102, Issue 3, Page 344-354, March 2025.
ABSTRACT The management of hypoglycaemia is pivotal in the care of patients with insulinoma. Blood glucose monitoring and regulation needs careful attention pre‐ and peri‐operatively for patients undergoing surgical resection and as part of the long‐term management for patients with inoperable or metastatic disease.
Sophie Howarth, Tak‐Wai Ho, James Wimbury, Ruth Casey   +3 more
wiley   +1 more source

BENZOTHIADIAZINES DERIVATIVES AS NOVEL ALLOSTERIC MODULATORS OF KAINIC ACID RECEPTORS

, 2022
The majority of excitatory neurotransmission in vertebrate CNS is mediated by glutamate binding to different types of receptors. Among them, a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and kainate receptors (KAR) are ionotropic ...
Puja G., Battisti U. M., Losi G., Ravazzini F., Bardoni R., Citti C., Cannazza G.   +6 more
core   +2 more sources

Bridgehead Nitrogen Heterocycles. Part-V. Syntheses of s-Triazolo[3,4-b][ 1,3,4,]benzothiadiazines, s-'Triazolo[3,4-b][1 ,3,4]thiadiazines, s-Triazolo[3,4-b][ 1 ,3,4]thiadiazino[5,6-b]quinoxaline, lmidazo[ 2, 1 -b ]benzothiazole and Benzimidazo[ 2,1-b] benzothiazole as Potential Antimicrobial A gents

, 1992
Department of Chemistry, Department of Zoology, Government Post-Graduate College, Churu-331 001 Manuscript received 10 October 1991, revised 8 September 1992, accepted 21 September 1992 Bridgehead Nitrogen Heterocycles. Part-V.
ANIL BHARGAVA, SANJAY JOSHI, VIJAY K. CHADHA   +2 more
core   +1 more source

Pioneering Metal‐Free Late‐Stage C−H Functionalization Using Acridinium Salt Photocatalysis

Chemistry – A European Journal, Volume 30, Issue 67, December 2, 2024.
Organic dyes are powerful photocatalysts in organic transformations due to their availability, adaptable absorption, and diverse structures. Acridinium‐based organo‐photocatalysts, notable for visible light responsiveness, efficiently functionalize inert C−H bonds under mild conditions without transition metals.
Shyamal Kanti Bera, Andrea Porcheddu
wiley   +1 more source

Synthesis and properties of some 4H-1, 3, 4 benzothiadiazines /|nby Darko J. Vukov. -- 260 St. Catharines, Ont. : [s. n.],

, 1972
The work herein has been divided into five sections. In the first section, a new method of converting N-aroyl- hydrazines to hydrazidic halides is described.
Vukov, Darko J.
core   +1 more source