Results 21 to 30 of about 547 (150)

Insulinoma in a dog (Canis lupus familiaris) with concurrent non‐cardiogenic pulmonary oedema

Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.
Abstract A 12‐year‐old, female, neutered beagle presented with hypoglycaemia, sudden‐onset non‐ambulatory tetraparesis and a single tonic‐clonic seizure. Computed tomography revealed a pancreatic nodule, consistent with an insulinoma, an enlarged hepatic lymph node and ground‐glass attenuation of the lung parenchyma, most consistent with non ...
Dylan O’ Toole, Julia Riggs, Tom Butler, Chantelle Franklin, Hannah Wong, Barbara Skelly   +5 more
wiley   +1 more source

Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Biological Characterization of Unsymmetrical Dialkyl-Hydroxynaphthalenoyl-benzothiadiazines

, 2016
The hepatitis C virus (HCV) NS5B polymerase is essential for viral replication and has been a prime target for drug discovery research. Our efforts directed toward the discovery of HCV polymerase inhibitors resulted in the identification of unsymmetrical
Douglas K. Hutchinson (2371957), Todd D. Bosse (2384224), John F. Darbyshire (2384245), Dale J. Kempf (2332114), Rolf Wagner (29866), Lisa E. Hernandez (2371939), John K. Pratt (2384242), Daniel P. Larson (2384236), Clarence J. Maring (1833961), Sherie V. Masse (2371963), Michelle A. Long (2384230), William Kohlbrenner (2384239), Wen W. Jiang (2371945), Yi Gao (112914), David W. A. Beno (2110654), Jinrong Liu (733835), Gennadiy Koev (1833994), Warren M. Kati (1833985), A. Chris Krueger (1833955), Tim Middleton (2384221), Larry L. Klein (1828195), Yaya Liu (2371966), Debra A. Montgomery (2371951), Akhteruzzaman Molla (2332132), Patricia Stuart (2384233), Bradley D. Gates (2384227), Wenping He (1408009), Rodger F. Henry (1744156)   +27 more
core   +1 more source

Thiazide‐Associated Hyponatremia: A Retrospective Cohort Study Comparing Hydrochlorothiazide Versus Indapamide Versus Chlorthalidone

The Journal of Clinical Hypertension, Volume 27, Issue 5, May 2025.
ABSTRACT Hyponatremia is a crucial complication of therapy with thiazide diuretics. This study compares the epidemiological and biochemical profiles and hospital course of patients using hydrochlorothiazide (HCTZ), indapamide (INDA), and chlorthalidone (CTD) admitted with thiazide‐associated hyponatremia (TAH).
Josef Klhůfek, Martin Vodička, Petr Ponížil, Ilja Ryšavý, Petr Fojtík, Vladimír Kojecký, Tomáš Šálek   +6 more
wiley   +1 more source

Managing Hypoglycaemia in Patients With Insulinoma—A Tertiary Centre Experience and Review of the Literature

Clinical Endocrinology, Volume 102, Issue 3, Page 344-354, March 2025.
ABSTRACT The management of hypoglycaemia is pivotal in the care of patients with insulinoma. Blood glucose monitoring and regulation needs careful attention pre‐ and peri‐operatively for patients undergoing surgical resection and as part of the long‐term management for patients with inoperable or metastatic disease.
Sophie Howarth, Tak‐Wai Ho, James Wimbury, Ruth Casey   +3 more
wiley   +1 more source

Discovery of Halogenated Benzothiadiazine Derivatives with Anticancer Activity**

ChemMedChem, 2020
Abstract Mitochondrial respiratory complex II (CII), also known as succinate dehydrogenase, plays a critical role in mitochondrial metabolism. Known but low potency CII inhibitors are selectively cytotoxic to cancer cells including the benzothiadiazine‐based anti‐hypoglycemic diazoxide.
Bader I. Huwaimel, Myla Bhakta, Chaitanya A. Kulkarni, Alexander S. Milliken, Feifei Wang, Aimin Peng, Paul S. Brookes, Paul C. Trippier   +7 more
openaire   +2 more sources

Pioneering Metal‐Free Late‐Stage C−H Functionalization Using Acridinium Salt Photocatalysis

Chemistry – A European Journal, Volume 30, Issue 67, December 2, 2024.
Organic dyes are powerful photocatalysts in organic transformations due to their availability, adaptable absorption, and diverse structures. Acridinium‐based organo‐photocatalysts, notable for visible light responsiveness, efficiently functionalize inert C−H bonds under mild conditions without transition metals.
Shyamal Kanti Bera, Andrea Porcheddu
wiley   +1 more source

Bridgehead Nitrogen Heterocycles. Part-V. Syntheses of s-Triazolo[3,4-b][ 1,3,4,]benzothiadiazines, s-'Triazolo[3,4-b][1 ,3,4]thiadiazines, s-Triazolo[3,4-b][ 1 ,3,4]thiadiazino[5,6-b]quinoxaline, lmidazo[ 2, 1 -b ]benzothiazole and Benzimidazo[ 2,1-b] benzothiazole as Potential Antimicrobial A gents

, 1992
Department of Chemistry, Department of Zoology, Government Post-Graduate College, Churu-331 001 Manuscript received 10 October 1991, revised 8 September 1992, accepted 21 September 1992 Bridgehead Nitrogen Heterocycles. Part-V.
ANIL BHARGAVA, SANJAY JOSHI, VIJAY K. CHADHA   +2 more
core   +1 more source

Effects of thiazides and new findings on kidney stones and dysglycemic side effects

Acta Physiologica, Volume 240, Issue 7, July 2024.
Abstract Thiazide and thiazide‐like diuretics (thiazides) belong to the most frequently prescribed drugs worldwide. By virtue of their natriuretic and vasodilating properties, thiazides effectively lower blood pressure and prevent adverse cardiovascular outcomes.
Matteo Bargagli, Manuel A. Anderegg, Daniel G. Fuster   +2 more
wiley   +1 more source

Heteroarylalkanoic acids with possible antiinflammatory activities, III

, 1985
The Ms deals with the synthesis and in vivo testing of a series of benzothiadiazines as antiinflammatory ...
PARENTI, Carlo, Di Bella M, Raffa L., COSTANTINO, Luca   +3 more
core   +1 more source

From Conventional to Sustainable Catalytic Approaches for Heterocycles Synthesis

ChemSusChem, Volume 17, Issue 8, April 22, 2024.
Catalysed synthetic methods, such as transition metals, organocatalysts, photocatalysts, iodine‐catalysed reaction, electrochemical reactions and green innovative methods are of great interest for the sustainable synthesis of heterocyclic compounds, important building blocks for several applications.
Carla Rizzo, Andrea Pace, Ivana Pibiri, Silvestre Buscemi, Antonio Palumbo Piccionello   +4 more
wiley   +1 more source