Results 11 to 20 of about 763 (164)
BTDAzo: A Photoswitchable TRPC5 Channel Activator. [PDF]
Angew Chem Int Ed Engl, 2022 Photoswitchable reagents can be powerful tools for high-precision biological control. TRPC5 is a Ca2+-permeable cation channel with distinct tissue-specific roles, from synaptic function to hormone regulation.
Müller M +7 more
europepmc +5 more sources
Insulinoma in a dog ( Canis lupus familiaris ) with concurrent non‐cardiogenic pulmonary oedema [PDF]
Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.A 12‐year‐old, female, neutered beagle presented with hypoglycaemia, sudden‐onset non‐ambulatory tetraparesis and a single tonic‐clonic seizure. Computed tomography revealed a pancreatic nodule, consistent with an insulinoma, an enlarged hepatic lymph ...
Dylan O’ Toole +5 more
core +3 more sources
Synthesis and In Vitro Antileishmanial Efficacy of Novel Ethylene Glycol Analogues of Benzothiadiazine-1,1-dioxide. [PDF]
Chem BiodiversAbstract Leishmaniasis is a vector‐borne, parasitic disease affecting millions of people and animals worldwide. Current therapeutic options have proven to be ineffective in both treating the disease and preventing its spread. As a result, new drugs must be developed to effectively combat this disease.
Henning N +6 more
europepmc +2 more sources
Virtual screening for NS5B inhibitors of Hepatitis C virus [PDF]
, 2012 Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality.
Achuthsankar S. Nair +2 more
core +5 more sources
Journal of Heterocyclic Chemistry, Volume 60, Issue 10, Page 1738-1759, October 2023., 2023 Substituted tricyclic and tetracyclic benzothiadiazines were synthesized in this paper, were synthesized via metal‐free intramolecular N‐iodosuccinimide (NIS)‐mediated radical oxidative sp3‐C‐H activation aminative cyclization. Docking studies of the tricyclic and angular tetracyclic 1,2,4‐benzothiadizine dioxides 26–34 and intermediates were carried ...
Sherif O. Kolade +7 more
wiley +1 more source
Chemistry – A European Journal, Volume 29, Issue 13, March 1, 2023., 2023 A copper(I)‐catalyzed interrupted domino reaction of 2‐azido sulfoximines with 1‐iodoalkynes affords fused triazolyl‐containing benzothiadiazine‐1‐oxides in good to excellent yields. The substrate scope is broad and the functional group tolerance high.
Renè Hommelsheim +6 more
wiley +1 more source
Journal of Analytical Methods in Chemistry, Volume 2023, Issue 1, 2023., 2023 Simple, accurate, precise, and cost‐effective chemometric techniques for the measurement of candesartan cilexetil and hydrochlorothiazide in synthetic mixtures were improved and validated. H‐point standard addition, Q‐absorption ratio, and correction absorbance spectrophotometric techniques were utilized for the simultaneous determination of both ...
Diyar Salahuddin Ali +1 more
wiley +1 more source
Molecular modeling studies, synthesis, configurational stability and biological activity of 8-chloro-2,3,5,6-tetrahydro-3,6-dimethyl-pyrrolo[1,2,3-de]-1,2,4-benzothiadiazine 1,1-dioxide [PDF]
, 2011 The potential therapeutic benefit of compounds able to activate AMPA receptors (AMPArs) has led to a search for new AMPAr positive modulators. Among them, 8-chloro-2,3,5,6-tetrahydro-3,6-dimethyl-pyrrolo[1,2,3-de]-1,2,4-benzothiadiazine 1,1-dioxide (1 ...
Battisti, UMBERTO MARIA +8 more
core +1 more source
Cross-genotypic examination of hepatitis C virus polymerase inhibitors reveals a novel mechanism of action for thumb binders. [PDF]
Antimicrob Agents Chemother, 2014 Eltahla AA, Tay E, Douglas MW, White PA.
europepmc +3 more sources
Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides. [PDF]
J Virol, 2004 The RNA-dependent RNA polymerase of hepatitis C virus (HCV) is necessary for the replication of viral RNA and thus represents an attractive target for drug development.
Tomei L +14 more
europepmc +3 more sources