Results 11 to 20 of about 600 (157)

BTDAzo: A Photoswitchable TRPC5 Channel Activator. [PDF]

Angew Chem Int Ed Engl, 2022
Photoswitchable reagents can be powerful tools for high‐precision biological control. TRPC5 is a Ca(2+)‐permeable cation channel with distinct tissue‐specific roles, from synaptic function to hormone regulation.
Müller M, Niemeyer K, Urban N, Ojha NK, Zufall F, Leinders-Zufall T, Schaefer M, Thorn-Seshold O.   +7 more
europepmc   +4 more sources

Synthesis and In Vitro Antileishmanial Efficacy of Novel Ethylene Glycol Analogues of Benzothiadiazine-1,1-dioxide. [PDF]

Chem Biodivers
Abstract Leishmaniasis is a vector‐borne, parasitic disease affecting millions of people and animals worldwide. Current therapeutic options have proven to be ineffective in both treating the disease and preventing its spread. As a result, new drugs must be developed to effectively combat this disease.
Henning N, Kannigadu C, Aucamp J, Janse van Rensburg HD, van der Kooy F, van der Kooy F, N'Da DD.   +6 more
europepmc   +2 more sources

Synthesis and molecular docking studies of novel tricyclic and angular tetracyclic benzothiadiazines via sp3‐C‐H activation as potential colon cancer inhibitors

Journal of Heterocyclic Chemistry, Volume 60, Issue 10, Page 1738-1759, October 2023., 2023
Substituted tricyclic and tetracyclic benzothiadiazines were synthesized in this paper, were synthesized via metal‐free intramolecular N‐iodosuccinimide (NIS)‐mediated radical oxidative sp3‐C‐H activation aminative cyclization. Docking studies of the tricyclic and angular tetracyclic 1,2,4‐benzothiadizine dioxides 26–34 and intermediates were carried ...
Sherif O. Kolade, Oluwafemi S. Aina, Allen T. Gordon, Eric C. Hosten, Idris A. Olasupo, Adeniyi S. Ogunlaja, Olayinka T. Asekun, Oluwole B. Familoni   +7 more
wiley   +1 more source

A Copper‐Catalyzed Interrupted Domino Reaction for the Synthesis of Fused Triazolyl Benzothiadiazine‐1‐oxides

Chemistry – A European Journal, Volume 29, Issue 13, March 1, 2023., 2023
A copper(I)‐catalyzed interrupted domino reaction of 2‐azido sulfoximines with 1‐iodoalkynes affords fused triazolyl‐containing benzothiadiazine‐1‐oxides in good to excellent yields. The substrate scope is broad and the functional group tolerance high.
Renè Hommelsheim, Sandra Bausch, Arjuna Selvakumar, Mostafa M. Amer, Khai‐Nghi Truong , Kari Rissanen, Carsten Bolm   +6 more
wiley   +1 more source

Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations

Journal of Analytical Methods in Chemistry, Volume 2023, Issue 1, 2023., 2023
Simple, accurate, precise, and cost‐effective chemometric techniques for the measurement of candesartan cilexetil and hydrochlorothiazide in synthetic mixtures were improved and validated. H‐point standard addition, Q‐absorption ratio, and correction absorbance spectrophotometric techniques were utilized for the simultaneous determination of both ...
Diyar Salahuddin Ali, Ricardo Jorgensen Cassella   +1 more
wiley   +1 more source

A case of insulinoma effectively treated with low‐dose diazoxide

Clinical Case Reports, Volume 8, Issue 10, Page 1884-1889, October 2020., 2020
Diazoxide is a benzothiadiazine that can be effective in managing hypoglycemia in frail patients with surgical risk. We report here a case of insulinoma effectively treated with diazoxide, as our report will be helpful for similar cases. Abstract Diazoxide is a benzothiadiazine that can be effective in managing hypoglycemia in frail patients with ...
Atsushi Yasuda, Toshiro Seki, Natsumi Kitajima, Tanefumi Baba, Noriko Sasaki, Yoshie Kametani, Masami Seki, Kazuko Tanaka, Masayuki Oki   +8 more
wiley   +1 more source

Pharmmaker: Pharmacophore modeling and hit identification based on druggability simulations

Protein Science, Volume 29, Issue 1, Page 76-86, January 2020., 2020
Abstract Recent years have seen progress in druggability simulations, that is, molecular dynamics simulations of target proteins in solutions containing drug‐like probe molecules to characterize their drug‐binding abilities, if any. An important consecutive step is to analyze the trajectories to construct pharmacophore models (PMs) to use for virtual ...
Ji Young Lee, James M. Krieger, Hongchun Li, Ivet Bahar   +3 more
wiley   +1 more source

Intramolecular Azide to Alkene Cycloadditions for the Construction of Pyrrolobenzodiazepines and Azetidino-Benzodiazepines [PDF]

, 2014
The coupling of proline- and azetidinone-substituted alkenes to 2-azidobenzoic and 2-azidobenzenesulfonic acid gives precursors that undergo intramolecular azide to alkene 1,3-dipolar cycloadditions to give imine-, triazoline- or aziridine-containing ...
O'Gorman, Paul A, Chambers, Christopher Steven, Christopher Chambers, Jamshaid, Faisal, Paul O'Gorman, Karl Hemming, Faisal Jamshaid, Hemming, Karl, Chambers, Christopher S, Christopher S. Chambers, Paul A. O'Gorman, Paul O\u27Gorman   +11 more
core   +1 more source

Highly Efficient Short‐Wavelength Infrared OLEDs at 1000 nm via Phosphorescent‐Host Engineering

Aggregate, Volume 7, Issue 6, June 2026.
A phosphorescent‐host strategy enables efficient SWIR OLEDs by harvesting both singlet and triplet excitons. The devices reach a record EQE of 2.64% at 920 nm, efficient emission at 1000 nm is achieved with an external quantum efficiency (EQE) exceeding 0.22% and a radiance of 1805 mW sr−1 m−2, establishing a general host‐engineering approach for SWIR ...
Zi‐Qi Feng, You‐Jun Yu, Zi‐Yu Song, Dong‐Ying Zhou, Zuo‐Quan Jiang, Liang‐Sheng Liao   +5 more
wiley   +1 more source

The synthesis of benzothiadiazines, benzothiadiazepines and benzothiadiazocines from intramolecular azide reactions and iodocyclisations

, 2009
N-Homoallyl-substituted (2-aminoaryl)sulfonamides undergo intramolecular iodocyclisation to furnish aziridine-fused 1,2,6-benzothiadiazocines. The identical aziridine-fused 1,2,6-benzothiadiazocines were also available from an intramolecular azide to ...
Chambers, Christopher Steven, Hemming, Karl, Patel, Nilesh, Chambers, Christopher S.   +3 more
core   +1 more source