Results 11 to 20 of about 547 (150)
Chlorinated benzothiadiazines inhibit angiogenesis through suppression of VEGFR2 phosphorylation. [PDF]
Bioorg Med Chem, 2022 Huwaimel BI +7 more
europepmc +2 more sources
, 2022 Quinazolinones/benzothiadiazines were used as amidyl/aminyl radical precursors for cascade cyclizations via a photoredox-catalyzed proton-coupled electron transfer (PCET) process for the first time.
Ramasamy Anandhan (3224679) +3 more
core +1 more source
Pharmmaker: Pharmacophore modeling and hit identification based on druggability simulations
Protein Science, Volume 29, Issue 1, Page 76-86, January 2020., 2020 Abstract Recent years have seen progress in druggability simulations, that is, molecular dynamics simulations of target proteins in solutions containing drug‐like probe molecules to characterize their drug‐binding abilities, if any. An important consecutive step is to analyze the trajectories to construct pharmacophore models (PMs) to use for virtual ...
Ji Young Lee +3 more
wiley +1 more source
Structure of benzothiadiazine at zwitterionic phospholipid cell membranes [PDF]
The Journal of Chemical Physics, 2021 The use of drugs derived from benzothiadiazine, which is a bicyclic heterocyclic benzene derivative, has become a widespread treatment for diseases such as hypertension (treated with diuretics such as bendroflumethiazide or chlorothiazide), low blood sugar (treated with non-diuretic diazoxide), or the human immunodeficiency virus, among others. In this
Hu, Zheyao +2 more
openaire +6 more sources
Canonical Transient Receptor Potential (TRPC) Channels in Nociception and Pathological Pain
Neural Plasticity, Volume 2020, Issue 1, 2020., 2020 Chronic pathological pain is one of the most intractable clinical problems faced by clinicians and can be devastating for patients. Despite much progress we have made in understanding chronic pain in the last decades, its underlying mechanisms remain elusive.
Zhi-Chuan Sun +5 more
wiley +1 more source
BENZOTHIADIAZINES DERIVATIVES AS NOVEL ALLOSTERIC MODULATORS OF KAINIC ACID RECEPTORS
, 2022 The majority of excitatory neurotransmission in vertebrate CNS is mediated by glutamate binding to different types of receptors. Among them, a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and kainate receptors (KAR) are ionotropic ...
Puja G. +6 more
core +2 more sources
, 2007 In continuation of our earlier work on benzothiadiazines, we have prepared a series of nitrofuran, nitrothiophene and arylfuran coupled benzothiadiazines and evaluated them for antimycobacterial and antibacterial activities.
Shetty, Rajesh V.C.R.N.C. +10 more
core +1 more source
Microbial Biotechnology, Volume 19, Issue 5, May 2026.bymBDZ accelerates early regrowth of persister‐derived E. coli and potentiates antibiotic killing. Its activity requires the MdtL–DcrB axis and is associated with envelope‐linked transport changes that increase intracellular small‐molecule exposure during recovery, thereby enhancing clearance in early treatment windows. ABSTRACT Persister cells survive
Garin Park, Hyein Kim, Sooyeon Song
wiley +1 more source
Pacing and Clinical Electrophysiology, Volume 49, Issue 5, Page 606-609, May 2026.ABSTRACT Background Permanent pacing in pediatric patients is complicated by small body size, vascular access limitations, and the need for durable long‐term management. Leadless pacemakers offer an emerging alternative that minimizes infection and lead‐related complications, yet vascular access remains a key challenge in young patients.
Marzia Giaccardi +4 more
wiley +1 more source
, 2009 N-Homoallyl-substituted (2-aminoaryl)sulfonamides undergo intramolecular iodocyclisation to furnish aziridine-fused 1,2,6-benzothiadiazocines. The identical aziridine-fused 1,2,6-benzothiadiazocines were also available from an intramolecular azide to ...
Chambers, Christopher Steven +3 more
core +1 more source