Results 11 to 20 of about 475 (128)

Synthesis and In Vitro Antileishmanial Efficacy of Novel Ethylene Glycol Analogues of Benzothiadiazine-1,1-dioxide. [PDF]

Chem Biodivers
Abstract Leishmaniasis is a vector‐borne, parasitic disease affecting millions of people and animals worldwide. Current therapeutic options have proven to be ineffective in both treating the disease and preventing its spread. As a result, new drugs must be developed to effectively combat this disease.
Henning N, Kannigadu C, Aucamp J, Janse van Rensburg HD, van der Kooy F, van der Kooy F, N'Da DD.   +6 more
europepmc   +2 more sources

Synthesis and molecular docking studies of novel tricyclic and angular tetracyclic benzothiadiazines via sp3‐C‐H activation as potential colon cancer inhibitors

Journal of Heterocyclic Chemistry, Volume 60, Issue 10, Page 1738-1759, October 2023., 2023
Substituted tricyclic and tetracyclic benzothiadiazines were synthesized in this paper, were synthesized via metal‐free intramolecular N‐iodosuccinimide (NIS)‐mediated radical oxidative sp3‐C‐H activation aminative cyclization. Docking studies of the tricyclic and angular tetracyclic 1,2,4‐benzothiadizine dioxides 26–34 and intermediates were carried ...
Sherif O. Kolade, Oluwafemi S. Aina, Allen T. Gordon, Eric C. Hosten, Idris A. Olasupo, Adeniyi S. Ogunlaja, Olayinka T. Asekun, Oluwole B. Familoni   +7 more
wiley   +1 more source

A Copper‐Catalyzed Interrupted Domino Reaction for the Synthesis of Fused Triazolyl Benzothiadiazine‐1‐oxides

Chemistry – A European Journal, Volume 29, Issue 13, March 1, 2023., 2023
A copper(I)‐catalyzed interrupted domino reaction of 2‐azido sulfoximines with 1‐iodoalkynes affords fused triazolyl‐containing benzothiadiazine‐1‐oxides in good to excellent yields. The substrate scope is broad and the functional group tolerance high.
Renè Hommelsheim, Sandra Bausch, Arjuna Selvakumar, Mostafa M. Amer, Khai‐Nghi Truong , Kari Rissanen, Carsten Bolm   +6 more
wiley   +1 more source

Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations

Journal of Analytical Methods in Chemistry, Volume 2023, Issue 1, 2023., 2023
Simple, accurate, precise, and cost‐effective chemometric techniques for the measurement of candesartan cilexetil and hydrochlorothiazide in synthetic mixtures were improved and validated. H‐point standard addition, Q‐absorption ratio, and correction absorbance spectrophotometric techniques were utilized for the simultaneous determination of both ...
Diyar Salahuddin Ali, Ricardo Jorgensen Cassella   +1 more
wiley   +1 more source

A case of insulinoma effectively treated with low‐dose diazoxide

Clinical Case Reports, Volume 8, Issue 10, Page 1884-1889, October 2020., 2020
Diazoxide is a benzothiadiazine that can be effective in managing hypoglycemia in frail patients with surgical risk. We report here a case of insulinoma effectively treated with diazoxide, as our report will be helpful for similar cases. Abstract Diazoxide is a benzothiadiazine that can be effective in managing hypoglycemia in frail patients with ...
Atsushi Yasuda, Toshiro Seki, Natsumi Kitajima, Tanefumi Baba, Noriko Sasaki, Yoshie Kametani, Masami Seki, Kazuko Tanaka, Masayuki Oki   +8 more
wiley   +1 more source

Pharmmaker: Pharmacophore modeling and hit identification based on druggability simulations

Protein Science, Volume 29, Issue 1, Page 76-86, January 2020., 2020
Abstract Recent years have seen progress in druggability simulations, that is, molecular dynamics simulations of target proteins in solutions containing drug‐like probe molecules to characterize their drug‐binding abilities, if any. An important consecutive step is to analyze the trajectories to construct pharmacophore models (PMs) to use for virtual ...
Ji Young Lee, James M. Krieger, Hongchun Li, Ivet Bahar   +3 more
wiley   +1 more source

Canonical Transient Receptor Potential (TRPC) Channels in Nociception and Pathological Pain

Neural Plasticity, Volume 2020, Issue 1, 2020., 2020
Chronic pathological pain is one of the most intractable clinical problems faced by clinicians and can be devastating for patients. Despite much progress we have made in understanding chronic pain in the last decades, its underlying mechanisms remain elusive.
Zhi-Chuan Sun, Sui-Bin Ma, Wen-Guang Chu, Dong Jia, Ceng Luo, Gernot Riedel   +5 more
wiley   +1 more source

A Novel Small Molecule Accelerates Early Persister Regrowth and Potentiates Antibiotic Killing via MdtL–DcrB

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
bymBDZ accelerates early regrowth of persister‐derived E. coli and potentiates antibiotic killing. Its activity requires the MdtL–DcrB axis and is associated with envelope‐linked transport changes that increase intracellular small‐molecule exposure during recovery, thereby enhancing clearance in early treatment windows. ABSTRACT Persister cells survive
Garin Park, Hyein Kim, Sooyeon Song
wiley   +1 more source

Transjugular Leadless Pacemaker Implantation in an Adolescent With Central Hypoventilation Syndrome: A Case Report

Pacing and Clinical Electrophysiology, Volume 49, Issue 5, Page 606-609, May 2026.
ABSTRACT Background Permanent pacing in pediatric patients is complicated by small body size, vascular access limitations, and the need for durable long‐term management. Leadless pacemakers offer an emerging alternative that minimizes infection and lead‐related complications, yet vascular access remains a key challenge in young patients.
Marzia Giaccardi, Gulio Porcedda, Zaccaria Ricci, Hendrik Bonnemeier, Benito Baldauf   +4 more
wiley   +1 more source

Insulinoma in a dog (Canis lupus familiaris) with concurrent non‐cardiogenic pulmonary oedema

Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.
Abstract A 12‐year‐old, female, neutered beagle presented with hypoglycaemia, sudden‐onset non‐ambulatory tetraparesis and a single tonic‐clonic seizure. Computed tomography revealed a pancreatic nodule, consistent with an insulinoma, an enlarged hepatic lymph node and ground‐glass attenuation of the lung parenchyma, most consistent with non ...
Dylan O’ Toole, Julia Riggs, Tom Butler, Chantelle Franklin, Hannah Wong, Barbara Skelly   +5 more
wiley   +1 more source