COMBINATORIAL PHARMACOPHORE MODELING AND ATOM BASED 3D QSAR STUDIES OF BENZOTHIADIAZINES AS HCV-NS5B INHIBITORS [PDF]
, 2018 Objective: The objective of the current study was to elucidate the 3D pharmacophoric features of benzothiadiazine derivatives that are crucial for inhibiting Hepatitis C virus (HCV) Non-structural protein 5B (NS5B) and quantifying the features by ...
Mahto, Manoj Kumar +2 more
core +1 more source
New derivatives of 1,2,4-benzothiadiazines and their coordination chemistry [PDF]
, 2018 Chapter 1 provides an introduction to coordination chemistry and polydentate N-donor ligands along with a synopsis of heterocycles with N and S/N donor atoms.
Pringouri, Konstantina
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Classification of HCV NS5B Polymerase Inhibitors Using Support Vector Machine [PDF]
, 2012 Using a support vector machine (SVM), three classification models were built to predict whether a compound is an active or weakly active inhibitor based on a dataset of 386 hepatitis C virus (HCV) NS5B polymerase NNIs (non-nucleoside analogue inhibitors)
Aixia Yan +36 more
core +4 more sources
Identificación y caracterización de los productos de degradación de las benzotiadiazinas en orina humana. Importancia para el control antidoping [PDF]
, 2008 Los diuréticos de tipo tiazidas (benzotiadiazinas) son ampliamente usados con fines terapéuticos. Al igual que otros diuréticos pueden ser utilizados ilegalmente en el deporte con el objetivo de evitar resultados positivos en el control antidoping por ...
Arístides Rosado Pérez +4 more
core +4 more sources
Clinical Pharmacology of Antihypertensive Therapy for the Treatment of Hypertension in CKD [PDF]
, 2019 CKD is common and frequently complicated with hypertension both predialysis and in ESKD. As a major modifiable risk factor for cardiovascular disease in this high-risk population, treatment of hypertension in CKD is important.
Agarwal, Rajiv, Sinha, Arjun D.
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An Assessment of the Use of Chimpanzees in Hepatitis C Research Past, Present and Future: 2. Alternative Replacement Methods [PDF]
, 2010 The use of chimpanzees in hepatitis C virus (HCV) research was examined in the report associated with this paper (1: Validity of the Chimpanzee Model), in which it was concluded that claims of past necessity of chimpanzee use were exaggerated, and that ...
Ahn J. +23 more
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Antiviral therapy for hepatitis C virus: beyond the standard of care [PDF]
, 2010 Hepatitis C virus (HCV) represents a major health burden, with an estimated 180 million chronically infected individuals worldwide. These patients are at increased risk of developing liver cirrhosis and hepatocellular carcinoma. Infection with HCV is the
Leen Delang +69 more
core +3 more sources
A Review of Sunlight Induced Cellular DNA Damage [PDF]
, 2014 We reviewed the literature on sunlight-induced DNA damage that leads to cancer in humans. Topics covered in this review are an introduction to sunlight radiation and examples of photo-induced DNA damage. The studies on sunlight radiation are covered in a
Aebisher, David, MacDavid, Kevin
core
DEVELOPMENT AND VALIDATION OF STABILITY-INDICATING HPTLC METHOD FOR THE ESTIMATION OF PERINDOPRIL AND INDAPAMIDE [PDF]
, 2014 Objective: To develop a validated stability indicating HPTLC method for determination Perindopril and Indapamide. Methods: The method was based on the separation of two drugs on plates precoated with silica gel 60 F254 using Dichloromethane: Methanol ...
Bhoir, Varsha +2 more
core +1 more source
National Assessment of Long-Term Groundwater Response to Pesticide Regulation. [PDF]
Environ Sci Technol, 2022 Kim H +5 more
europepmc +1 more source