Results 71 to 80 of about 134,591 (304)

The potential impact of H1 antihistamines on clinical outcomes in NSCLC patients undergoing EGFR‐TKIs treatment

British Journal of Clinical Pharmacology, EarlyView.
Background Epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR‐TKIs) have substantially improved outcomes in non‐small cell lung cancer (NSCLC); however, the development of treatment resistance remains a major clinical challenge. This study examines the association between concomitant prescriptions of H1‐antihistamines (H1AHs) and ...
Van Thuan Nguyen, Ngoc Hoang Le, Nhu Quynh Phan, Toan Trung Duong, Le Thi Anh Thu, Hsuan‐Chia Yang, Chih‐Wei Huang, Min‐Huei Hsu, Jason C. Hsu, Chien‐Tien Su, Phung‐Anh Nguyen   +10 more
wiley   +1 more source

Mechanism of diuretics [PDF]

This infographic provides an overview of diuretics, detailing their mechanisms including thiazide, loop, potassium-sparing, carbonic anhydrase inhibitors, and osmotic diuretics, along with discussions on their side effects, site of action, prototype drug,
Wisco, Jonathan J., Cengiz, Kayra
core   +1 more source

CYP3A5 genetic variability influences sildenafil and metabolite in pulmonary hypertension

British Journal of Clinical Pharmacology, EarlyView.
Aim Interindividual variability in sildenafil response among pulmonary hypertension patients (PH) may be influenced by CYP3A5 polymorphisms. CYP3A5*3 allele reduces CYP3A5 activity and affects sildenafil metabolism. This study investigated the associations between CYP3A5 genotype and plasma concentrations of sildenafil and N‐desmethyl sildenafil, as ...
Pranisa Wongwien, Burabha Pussadhamma, Sirimas Kanjanawart, Thikhumporn Areesinpitak, Nontaya Nakkam, Chingching Foocharoen, Wichittra Tassaneeyakul, Suda Vannaprasaht   +7 more
wiley   +1 more source

Outcome of renal transplantation with and without intra-operative diuretics

, 2011
Aims: This paper presents an e-survey of current clinical practice of use of intra-operative diuretics during renal transplantation in the United Kingdom and a study to compare outcome of renal transplants carried out with or without intra-operative ...
M.G. Littlejohn, M.J. Clancy, Littlejohn, M.G., Clancy, M.J., Hanif, F., E. Murio, F. Hanif, Macrae, A.N., Murio, E., A.N. Macrae   +9 more
core   +1 more source

Rational dosing of diuretics in the treatment of chronic heart failure with acute deterioration [PDF]

, 2022
For decades, diuretics have been the cornerstone in the treatment of patients with chronic heart failure with reduced ejection fraction (HFrEF) presenting with congestion. However, evidence guiding the use of diuretics is generally lacking.
Basaran, Tayfun, Antonsen, Lisbeth, Møller, Jacob Eifer, Poulsen, Mikael Kjær, Ahmed, Mohamed Abdullahi   +4 more
core  

Comparative treatment effects of direct oral anticoagulants versus warfarin for nonvalvular atrial fibrillation in clinical practice vary over time due to channelling

British Journal of Clinical Pharmacology, EarlyView.
Aim Temporal shifts in patient characteristics can influence comparative treatment effects within a certain indication. We investigated patient characteristics and comparative effectiveness and safety for direct oral anticoagulants (DOACs) and warfarin over the time period where DOACs replaced warfarin as preferred stroke prophylaxis in patients with ...
Raoul B. L. J. van den Hemel, Aernoud T. L. Fiolet, Magdalena A. Gamba, Patrick C. Souverein, Olaf H. Klungel, Lourens T. Bloem, Sophie H. Bots   +6 more
wiley   +1 more source

Percutaneous Left Atrial Appendage Closure Using a PFO Occluder After an Incomplete Surgical Ligation

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT The case regards a 73‐year‐old male who was referred for consideration of percutaneous left atrial appendage closure. His left atrial appendage was ligated during prior mitral valve surgery, but was noted to be patent on a recent transesophageal echocardiography. An Amulet device was selected based on CT planning.
Zach Rozenbaum, Eric Gnall
wiley   +1 more source

The Use of Diuretics in Infants with Established or Evolving Bronchopulmonary Dysplasia and Its Impact on the Duration of Home Oxygen Therapy

Objective: Bronchopulmonary dysplasia (BPD), defined according to the level of respiratory support and supplemental oxygen administered at 36 weeks postmenstrual age, has multi-factorial causes.
Jayesh Mahendra Bhatt, Andrew Prayle, Yung Ci Chai, Dushyant Batra   +3 more
core   +1 more source

Baseline Body Mass Index Category and Incident Treated Hypertension in Australian Men: A Linked Prospective Cohort Study Using PBS/MBS Data

Chronic Diseases and Translational Medicine, EarlyView.
Kaplan–Meier hypertension‐free survival by baseline body mass index category, primary adult cohort (men aged ≥ 18 years, n = 12,742). Time since baseline in years is plotted on the horizontal axis and the probability of remaining free of treated hypertension is plotted on the vertical axis. Numbers at risk are shown beneath the plot.
Ebenezer Afrifa‐Yamoah
wiley   +1 more source

Women have a higher risk of hospital admission associated with hyponatremia than men while using diuretics

Frontiers in Pharmacology
BackgroundHyponatremia is a common electrolyte disturbance and known adverse drug reaction of diuretics. Women tend to be more susceptible for diuretic associated hyponatremia.
L. C. Hendriksen, L. C. Hendriksen, M. S. Mouissie, M. S. Mouissie, R. M. C. Herings, R. M. C. Herings, P. D. van der Linden, L. E. Visser, L. E. Visser, L. E. Visser   +9 more
doaj   +1 more source