Dosage-sensitive requirement for mouse Dll4 in artery development [PDF]
Genes & Development, 2004 Involvement of the Notch signaling pathway in vascular development has been demonstrated by both gain- and loss-of-function mutations in humans, mice, and zebrafish. In zebrafish, Notch signaling is required for arterial identity by suppressing the venous fate in developing artery cells.
António, Duarte +8 more
openaire +2 more sources
RET mutation and increased angiogenesis in medullary thyroid carcinomas [PDF]
, 2016 Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit receptor tyrosine kinases, many of which involved in angiogenesis.
Acquaviva, Giorgia +16 more
core +1 more source
A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse
Biology Open, 2018 Canonical Notch signaling requires the presence of a membrane bound ligand and a corresponding transmembrane Notch receptor. Receptor engagement induces multiple proteolytic cleavage events culminating in the nuclear accumulation of the Notch ...
Alexander M. Herman +5 more
doaj +1 more source
Co-Emergence of Specialized Endothelial Cells from Embryonic Stem Cells. [PDF]
, 2018 A well-formed and robust vasculature is critical to the health of most organ systems in the body. However, the endothelial cells (ECs) forming the vasculature can exhibit a number of distinct functional subphenotypes like arterial or venous ECs, as well ...
Douglas, Simone A +6 more
core +1 more source
Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo. [PDF]
PLoS Genetics, 2015 Notch signalling is a fundamental pathway that shapes the developing embryo and sustains adult tissues by direct communication between ligand and receptor molecules on adjacent cells.
Kristina Preuße +7 more
doaj +1 more source
The intestinal lymphatic system: Functions and metabolic implications [PDF]
, 2019 The lymphatic system of the gut plays important roles in the transport of dietary lipids, as well as in immunosurveillance and removal of interstitial fluid.
Cifarelli, Vincenza, Eichmann, Anne
core +2 more sources
Context- and cell-dependent effects of Delta-like 4 targeting in the bone marrow microenvironment.
PLoS ONE, 2012 Delta-like 4 (Dll4) is a ligand of the Notch pathway family which has been widely studied in the context of tumor angiogenesis, its blockade shown to result in non-productive angiogenesis and halted tumor growth.
Leonor Remédio +7 more
doaj +1 more source
Incomplete Dll4/Notch signaling inhibition promotes functional angiogenesis supporting the growth of skin papillomas [PDF]
, 2015 BACKGROUND: In invasive malignancies, Dll4/Notch signaling inhibition enhances non-functional vessel proliferation and limits tumor growth by reducing its blood perfusion.
Adrian L. Harris +5 more
core +1 more source
Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth [PDF]
Molecular Cancer Therapeutics, 2016 Abstract Delta-like ligand 4 (Dll4), one of the Notch ligands, is overexpressed in ovarian cancer, especially in tumors resistant to anti-VEGF therapy. Here, we examined the biologic effects of dual anti-Dll4 and anti-VEGF therapy in ovarian cancer models.
Jie, Huang +16 more
openaire +2 more sources
Anti-DLL4 Has Broad Spectrum Activity in Pancreatic Cancer Dependent on Targeting DLL4-Notch Signaling in Both Tumor and Vasculature Cells [PDF]
Clinical Cancer Research, 2012 Abstract Purpose: We previously showed that targeting Delta-like ligand 4 (DLL4) in colon and breast tumors inhibited tumor growth and reduced tumor initiating cell frequency. In this report, we have extended these studies to pancreatic cancer and probed the mechanism of action in tumor and stromal cells involved in antitumor efficacy.
Wan-Ching, Yen +12 more
openaire +2 more sources