Results 21 to 30 of about 35,348 (219)

The use of dimethylsulfoxide as a solvent in enzyme inhibition studies: the case of aldose reductase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Aldose reductase (AR) is an enzyme devoted to cell detoxification and at the same time is strongly involved in the aetiology of secondary diabetic complications and the amplification of inflammatory phenomena.
Livia Misuri, Mario Cappiello, Francesco Balestri, Roberta Moschini, Vito Barracco, Umberto Mura, Antonella Del-Corso   +6 more
doaj   +1 more source

Methionine Sulfoxide Reductase A (MsrA) and Its Function in Ubiquitin-Like Protein Modification in Archaea

mBio, 2017
Methionine sulfoxide reductase A (MsrA) is an antioxidant enzyme found in all domains of life that catalyzes the reduction of methionine-S-sulfoxide (MSO) to methionine in proteins and free amino acids.
Xian Fu, Zachary Adams, Rui Liu, Nathaniel L. Hepowit, Yifei Wu, Connor F. Bowmann, Jackob Moskovitz, Julie A. Maupin-Furlow   +7 more
doaj   +1 more source

Optimization of the Solvent and In Vivo Administration Route of Auranofin in a Syngeneic Non-Small Cell Lung Cancer and Glioblastoma Mouse Model

Pharmaceutics, 2022
The antineoplastic activity of the thioredoxin reductase 1 (TrxR) inhibitor, auranofin (AF), has already been investigated in various cancer mouse models as a single drug, or in combination with other molecules.
Laurie Freire Boullosa, Jinthe Van Loenhout, Christophe Hermans, Ho Wa Lau, Céline Merlin, Elly Marcq, Farnaz Sedigheh Takhsha, Wim Martinet, Guido R. Y. De Meyer, Filip Lardon, Evelien L. J. Smits, Christophe Deben   +11 more
doaj   +1 more source

Participation of genes involved in the process of anaerobic respiration of infection in chickens by Salmonella Typhimurium

Brazilian Journal of Veterinary Pathology, 2010
Intestinal pathogens are exposed to various stress conditions during their infectious cycle. Anaerobiosis, one of such hostile condition, is offered by the host within gut and intestinal lumen, where survival, multiplication and entry into intestinal ...
Yuli M. S. Arguello, Jacqueline B. de Paiva, Rafael A. C. Penha Filho, Ângelo Berchieri Junior   +3 more
doaj   +1 more source

Effect of Trehalose and Sucrose in Post-thaw Quality of Crassostrea angulata Sperm

Frontiers in Physiology, 2021
Sperm cryopreservation can be a helpful tool in reproductive management and preservation of biodiversity. However, the freezing methodologies lead to some damage in structure and function of cells that may compromise post-thaw sperm activity ...
Catarina Anjos, Catarina Anjos, Ana Luísa Santos, Daniel Duarte, Domitília Matias, Elsa Cabrita   +5 more
doaj   +1 more source

A novel, molybdenum-containing methionine sulfoxide reductase supports survival of Haemophilus influenzae in an in vivo model of infection

Frontiers in Microbiology, 2016
H. influenzae is a host adapted human mucosal pathogen involved in a variety of acute and chronic respiratory tract infections, including Chronic Obstructive Pulmonary Disease (COPD) and asthma, all of which rely on ability to efficiently establish ...
Rabeb Dhouib, Dk Seti Maimonah Pg Othman, Victor Lin, Xuanjie Jason Lai, Hewa Godage Sithija Wijesinghe, Ama-Tawiah Essilfie, Amanda Davis, Amanda Davis, Marufa Nasreen, Paul V Bernhardt, Philip Michael Hansbro, Alastair G McEwan, Ulrike Kappler   +12 more
doaj   +1 more source

Comparative genomics of Photobacterium species from terrestrial and marine habitats

Current Research in Microbial Sciences, 2021
Photobacterium (P.) is a genus widely studied in regards to its association with and ubiquitous presence in marine environments. However, certain species (P. phosphoreum, P. carnosum, P.
Sandra Fuertes-Perez, Rudi F. Vogel, Maik Hilgarth   +2 more
doaj   +1 more source

Bioreduction of Idarubicin and Formation of ROS Responsible for DNA Cleavage by NADPH-Cytochrome P450 Reductase and its Potential Role in the Antitumor Effect

Journal of Pharmacy & Pharmaceutical Sciences, 2009
PURPOSE. Idarubicin is a clinically effective synthetic anthracycline analog used in the treatment of several human neoplasms. Anthracyclines have the potential to undergo bioactivation by flavoenzymes to free radicals and thus exert their cytotoxic ...
Haydar Çelik, Emel Arinç
doaj   +1 more source

Large Density-Functional and Basis-Set Effects for the DMSO Reductase Catalyzed Oxo-Transfer Reaction [PDF]

Journal of Chemical Theory and Computation, 2013
The oxygen-atom transfer reaction catalyzed by the mononuclear molybdenum enzyme dimethyl sulfoxide reductase (DMSOR) has attracted considerable attention through both experimental and theoretical studies. We show here that this reaction is more sensitive to details of quantum mechanical calculations than what has previously been appreciated.
Li, Ji-Lai, Mata, Ricardo A., Ryde, Ulf
openaire   +3 more sources

Growth Enhancement Facilitated by Gaseous CO₂ through Heterologous Expression of Reductive Tricarboxylic Acid Cycle Genes in Escherichia coli

Fermentation, 2021
The enzymatic mechanisms of carbon fixation by autotrophs, such as the reductive tricarboxylic acid cycle (rTCA), have inspired biotechnological approaches to producing bio-based chemicals directly through CO2.
Shou-Chen Lo, En-Pei Isabel Chiang, Ya-Tang Yang, Si-Yu Li, Jian-Hau Peng, Shang-Yieng Tsai, Dong-Yan Wu, Chia-Hua Yu, Chu-Han Huang, Tien-Tsai Su, Kenji Tsuge, Chieh-Chen Huang   +11 more
doaj   +1 more source