Results 21 to 30 of about 202,224 (260)

Optimization of the Solvent and In Vivo Administration Route of Auranofin in a Syngeneic Non-Small Cell Lung Cancer and Glioblastoma Mouse Model

open access: yesPharmaceutics, 2022
The antineoplastic activity of the thioredoxin reductase 1 (TrxR) inhibitor, auranofin (AF), has already been investigated in various cancer mouse models as a single drug, or in combination with other molecules.
Laurie Freire Boullosa   +11 more
doaj   +1 more source

Participation of genes involved in the process of anaerobic respiration of infection in chickens by Salmonella Typhimurium

open access: yesBrazilian Journal of Veterinary Pathology, 2010
Intestinal pathogens are exposed to various stress conditions during their infectious cycle. Anaerobiosis, one of such hostile condition, is offered by the host within gut and intestinal lumen, where survival, multiplication and entry into intestinal ...
Yuli M. S. Arguello   +3 more
doaj   +1 more source

Effect of Trehalose and Sucrose in Post-thaw Quality of Crassostrea angulata Sperm

open access: yesFrontiers in Physiology, 2021
Sperm cryopreservation can be a helpful tool in reproductive management and preservation of biodiversity. However, the freezing methodologies lead to some damage in structure and function of cells that may compromise post-thaw sperm activity ...
Catarina Anjos   +5 more
doaj   +1 more source

A novel, molybdenum-containing methionine sulfoxide reductase supports survival of Haemophilus influenzae in an in vivo model of infection

open access: yesFrontiers in Microbiology, 2016
H. influenzae is a host adapted human mucosal pathogen involved in a variety of acute and chronic respiratory tract infections, including Chronic Obstructive Pulmonary Disease (COPD) and asthma, all of which rely on ability to efficiently establish ...
Rabeb Dhouib   +12 more
doaj   +1 more source

Comparative genomics of Photobacterium species from terrestrial and marine habitats

open access: yesCurrent Research in Microbial Sciences, 2021
Photobacterium (P.) is a genus widely studied in regards to its association with and ubiquitous presence in marine environments. However, certain species (P. phosphoreum, P. carnosum, P.
Sandra Fuertes-Perez   +2 more
doaj   +1 more source

Artifact Peaks Due to Minor Decomposition of Sample Diluent DMSO in Head Space-GC Analysis: Mass Spectrometric Investigation Using Deuterated DMSO and Quadrupole Time-of-Flight Mass Detection [PDF]

open access: yes, 2021
Rationale: Head space gas chromatography (HS-GC) has become a widely used analytical technique for residual solvents determination in drug substances and drug products.
Wenbin, Chen   +8 more
core   +1 more source

Bioreduction of Idarubicin and Formation of ROS Responsible for DNA Cleavage by NADPH-Cytochrome P450 Reductase and its Potential Role in the Antitumor Effect

open access: yesJournal of Pharmacy & Pharmaceutical Sciences, 2009
PURPOSE. Idarubicin is a clinically effective synthetic anthracycline analog used in the treatment of several human neoplasms. Anthracyclines have the potential to undergo bioactivation by flavoenzymes to free radicals and thus exert their cytotoxic ...
Haydar Çelik, Emel Arinç
doaj   +1 more source

Dendrimer Encapsulation of [MoVOS4] Cores:  Implications for the DMSO Reductase Family of Enzymes

open access: yes, 2016
Dendrimer Encapsulation of [MoVOS4] Cores:  Implications for the DMSO Reductase Family of ...
Partha Basu (1328442)   +1 more
core   +1 more source

Large Density-Functional and Basis-Set Effects for the DMSO Reductase Catalyzed Oxo-Transfer Reaction [PDF]

open access: yesJournal of Chemical Theory and Computation, 2013
The oxygen-atom transfer reaction catalyzed by the mononuclear molybdenum enzyme dimethyl sulfoxide reductase (DMSOR) has attracted considerable attention through both experimental and theoretical studies. We show here that this reaction is more sensitive to details of quantum mechanical calculations than what has previously been appreciated.
Li, Ji-Lai, Mata, Ricardo A., Ryde, Ulf
openaire   +3 more sources

The Oxo-Gate Hypothesis and DMSO Reductase:  Implications for a Psuedo-σ Bonding Interaction Involved in Enzymatic Electron Transfer

open access: yes, 2016
The Oxo-Gate Hypothesis and DMSO Reductase:  Implications for a Psuedo-σ Bonding Interaction Involved in Enzymatic Electron ...
Rebecca L. McNaughton (1949137)   +3 more
core   +1 more source

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