Results 31 to 40 of about 35,348 (219)

Unsymmetrical Trifluoromethyl Methoxyphenyl β-Diketones: Effect of the Position of Methoxy Group and Coordination at Cu(II) on Biological Activity

Molecules, 2021
Copper(II) complexes with 1,1,1-trifluoro-4-(4-methoxyphenyl)butan-2,4-dione (HL1) were synthesized and characterized by elemental analysis, FT-IR spectroscopy, and single crystal X-ray diffraction. The biological properties of HL1 and cis-[Cu(L1)2(DMSO)]
Liliya A. Khamidullina, Igor S. Puzyrev, Gennady L. Burygin, Pavel V. Dorovatovskii, Yan V. Zubavichus, Anna V. Mitrofanova, Victor N. Khrustalev, Tatiana V. Timofeeva, Pavel A. Slepukhin, Polina D. Tobysheva, Alexander V. Pestov, Euro Solari, Alexander G. Tskhovrebov, Valentine G. Nenajdenko   +13 more
doaj   +1 more source

An Asymmetrically Substituted Aliphatic Bis-Dithiolene Mono-Oxido Molybdenum(IV) Complex With Ester and Alcohol Functions as Structural and Functional Active Site Model of Molybdoenzymes

Frontiers in Chemistry, 2019
A MoIV mono-oxido bis-dithiolene complex, [MoO(mohdt)2]2− (mohdt = 1-methoxy-1-oxo-4-hydroxy-but-2-ene-2,3-bis-thiolate) was synthesized as a structural and functional model for molybdenum oxidoreductase enzymes of the DMSO reductase family.
Mohsen Ahmadi, Christian Fischer, Ashta C. Ghosh, Carola Schulzke   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The DmsABC Sulfoxide Reductase Supports Virulence in Non-typeable Haemophilus influenzae

Frontiers in Microbiology, 2021
Although molybdenum-containing enzymes are well-established as having a key role in bacterial respiration, it is increasingly recognized that some may also support bacterial virulence.
Rabeb Dhouib, Marufa Nasreen, Dk Seti Maimonah Pg Othman, Daniel Ellis, Simon Lee, Ama-Tawiah Essilfie, Philip M. Hansbro, Alastair G. McEwan, Ulrike Kappler   +8 more
doaj   +1 more source

Detection of the optical bands of molybdenum(V) in DMSO reductase (Rhodobacter capsulatus) by low‐temperature MCD spectroscopy [PDF]

FEBS Letters, 1992
Dimethylsulphoxide (DMSO) reductase from R. capsulatus contains a molybdenum‐pterin cofactor at its active site. As prepared the molybdenum is in the 6+ oxidation state, devoid of EPR signals. Stepwise reduction generates an EPR signal characteristic of Mo(V) having hyperfine coupling to a single proton and integrating to less than 25% of the total ...
Benson, Neil, Farrar, Jaqui A., McEwan, Alastair G., Thomson, Andrew J.   +3 more
openaire   +5 more sources

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications

Angewandte Chemie, EarlyView.
Photolysis of cysteine phenacylsulfides bearing non‐conjugating electron‐withdrawing substituents leads to high conversions into cysteine thioaldehydes through a Norrish type‐II pathway. This methodology enabled the study of the aqueous reactivity of these important biosynthetic intermediates, which, depending on peptide sequence, pH and buffer ...
Ardra Karthika, Matthew Murray, Guillermo Palop, Lee‐Ann J. Keane, Patrick McArdle, Nicholas D. J. Yates, Christopher D. Spicer, Alison Parkin, Martin A. Fascione, Eddie L. Myers   +9 more
wiley   +2 more sources

Oxygen and nitrate-dependent regulation of dmsABC operon expression in Escherichia coli: sites for Fnr and NarL protein interactions

BMC Microbiology, 2002
Background Escherichia coli can respire anaerobically using dimethyl sulfoxide (DMSO) or trimethylamine-N-oxide (TMAO) as the terminal electron acceptor for anaerobic energy generation.
Albrecht Jeffrey A, Bearson Shawn MD, Gunsalus Robert P   +2 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Should I Stay or Should I Go—Leveraging an Overlooked Feature of Click‐to‐Release Chemistry for Affinity Labeling

Angewandte Chemie, EarlyView.
Click‐to‐release (C2R) chemistry is redirected from payload liberation toward ligand‐directed covalent protein labeling through a transient dihydropyridazine methide (DHP‐methide). This concept opens the way to dual‐functional systems combining covalent target engagement with controlled effector release.
Dóra Kern, Krisztina Németh, Tímea Imre, József Simon, Kitti Meggyes, Gergő Bárdos, László Petri, Márton Bojtár, Attila Kormos, Péter Kele   +9 more
wiley   +2 more sources