Results 121 to 130 of about 32,964 (245)

Racial and ethnic disparities in disease-modifying therapy use among adults with multiple sclerosis: a real-world analysis of the All of Us Research Program

Frontiers in Neurology
IntroductionRacial and ethnic disparities in multiple sclerosis (MS) disease-modifying therapy (DMT) use are documented but incompletely characterized across the full treatment pathway.MethodsWe conducted a retrospective cohort study using the All of Us ...
Victoria Fontánez-Ramos, Jonathan Barreto-Nieves, Grecia A. Carrasquillo-Sanabria, Jorge F. García-Báez, Yaritza Inostroza-Nieves   +4 more
doaj   +1 more source

Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology

European Journal of Organic Chemistry, EarlyView.
Chelation‐assisted transition metal catalysis has emerged as a promising complement to bioorthogonal click chemistry for studying biological processes. By pre‐organizing catalytic metal centers, designed coordinating substrates enhance reactivity and biocompatibility, enabling site‐selective ligation and decaging reactions in complex biological media ...
Emilie Plantiveau, Maxime Riberaud, Frédéric Taran, Antoine Sallustrau   +3 more
wiley   +1 more source

Synthesis of Naphthoquinones by Pd‐Catalyzed Heck–Matsuda Arylation of Lapachol

European Journal of Organic Chemistry, EarlyView.
Direct Heck–Matsuda arylation of lapachol enables the efficient synthesis of diverse naphthoquinones under homogeneous and heterogeneous palladium catalysis. The methodology features broad substrate scope, gram‐scale applicability, and provides a practical platform for quinone diversification.
Breno U. de Abreu, Renata G. Almeida, Ana L. C. Silveira, Leonardo A. Matos, Willian X. C. Oliveira, Maria H. Araujo, Victor F. S. Ramos, Rubem F. S. Menna‐Barreto, Chandrakant B. Nichinde, Felipe Fantuzzi, Edmond Gravel, Eric Doris, Eufrânio N. da Silva Júnior, Guilherme A. M. Jardim   +13 more
wiley   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Amyloid‐β–Related Cortical Susceptibility Alterations in Individuals Under Assessment for Alzheimer's Disease: A χ‐Separation Study

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Assessment of amyloid‐β (Aβ) burden and associated iron deposition and neurodegeneration is important for Alzheimer's disease (AD) management. Although quantitative susceptibility mapping (QSM) detects iron and myelin changes, conventional metrics suffer from signal cancelation between paramagnetic and diamagnetic components ...
Hiroyuki Tatekawa, Tatsushi Oura, Akitoshi Takeda, Ayako Omori, Natsuko Atsukawa, Shu Matsushita, Daisuke Horiuchi, Hirotaka Takita, Yasuhito Mitsuyama, Yoshihito Ban, Taro Shimono, Josef Pfeuffer, Daiju Ueda, Yoshiaki Itoh, Yukio Miki   +14 more
wiley   +1 more source

Preserved anterolateral ligament graft continuity on MRI and lower knee laxity after ACL graft failure than before index combined ACL–ALL reconstruction: A retrospective case series

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To evaluate magnetic resonance imaging (MRI)‐based continuity and signal characteristics of reconstructed anterolateral ligament (ALL) grafts and compare anteroposterior and rotational knee laxity after anterior cruciate ligament (ACL) graft failure with values recorded before the index combined ACL–ALL reconstruction.
Renata Vidal Leão, Debora Mayumi Takamune, Andre Giardino Moreira da Silva, Gabriela Ribeiro Camerin, Diego Ariel de Lima, Camilo Partezani Helito   +5 more
wiley   +1 more source

First 20 Years of Orbitrap Mass Spectrometry as the Mainstream Analytical Technique

Mass Spectrometry Reviews, EarlyView.
ABSTRACT This review traces the first 20 years of Orbitrap mass spectrometry as a mainstream high‑resolution and accurate‑mass (HR/AM) technology. It outlines the historical development of the Orbitrap analyzer, the evolution of major instrument families, and the key technological innovations that enabled its widespread adoption. Particular emphasis is
Alexander Makarov
wiley   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Perceptual defensiveness and ESP performance: Reconstructed DMT ratings and psychological correlates in the first German DMT-ESP experiment

, 2002
The concept of perceptual defensiveness is related to subliminal perception and preconscious processing. Meta-analyses of earlier experiments, 6 in the United States and Holland and 10 in Iceland, on the Defense Mechanism Test (DMT)-ESP relationship had ...
Haraldsson, E, Schneider, R, Bäckström, Martin, Houtkooper, JM   +3 more
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